[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599500":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":17,"responsibleParty":34,"collaborators":7,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":7,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":7,"studyType":49,"phases":7,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":19,"whyStopped":7,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},{"fullName":5,"class":6},"Nanjing First Hospital, Nanjing Medical University","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Junshan Zhou","CONTACT","8602587726218","zhjsh333@126.com",{"name":15,"role":11,"phone":12,"phoneExt":7,"email":16},"Mengmeng Gu","gumengmeng322@yeah.net",[18],{"facility":5,"status":19,"city":20,"state":21,"zip":22,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"RECRUITING","Nanjing","Jiangsu","210006","China","CN",{"type":26,"coordinates":27},"Point",[28,29],118.77778,32.06167,{"lat":29,"lon":28},[32,33],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},{"name":15,"role":11,"phone":12,"phoneExt":7,"email":16},{"type":35,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100599500","gut-microbiota-and-prognostic-outcomes-in-intracranial-arterial-stenosis-patientsgrow-icas-100599500",false,"NCT07085299","Gut Microbiota and Prognostic Outcomes in Intracranial Arterial Stenosis Patients（GROW-ICAS）","Correlation Study Between Gut Microbiota and Prognosis in Patients With Intracranial Arterial Stenosis（GROW-ICAS）","Inclusion Criteria:\n\n1. Age 30-80 years.\n2. Intracranial arterial stenosis confirmed by CTA\u002FMRA\u002FDSA.\n3. Local residency ≥6 consecutive months.\n4. Signed informed consent.\n\nExclusion Criteria:\n\n1. Tandem extracranial stenosis (≥50%) proximal to the target intracranial stenotic vessel.\n2. Non-atherosclerotic intracranial stenosis.\n3. Extracranial\u002Fintracranial endovascular treatment within 30 days pre-enrollment or planned intervention within 6 months.\n4. Intracranial hemorrhage within 90 days pre-enrollment.\n5. Pre-existing intracranial tumor, cerebral aneurysm, or arteriovenous malformation.\n6. Cardioembolic embolism.\n7. Active bleeding\u002Fhemorrhagic diathesis.\n8. Major surgery within 30 days pre-enrollment or planned within 6 months post-enrollment.\n9. Severe neurological deficits impairing independent living or dementia\u002Fpsychiatric disorders hindering follow-up.\n10. Pregnancy\u002Flactation\u002Fplanned pregnancy.\n11. Chronic inflammatory\u002Fautoimmune diseases.\n12. Uncontrolled hypertension or diabetes.\n13. Severe cardiac\u002Fhepatic\u002Frenal dysfunction, hematologic disorders, malignancy, or life expectancy \\\u003C1 year.\n14. MRI contraindications.\n15. History of depression\u002Fanxiety\u002Fcognitive impairment requiring therapy.\n16. Antibiotic\u002Fprobiotic\u002Fglucocorticoid\u002Fimmunosuppressant use within 1 month pre-enrollment.\n17. Current\u002Fplanned participation in other trials.\n18. Inability to cooperate due to psychiatric\u002Femotional disorders.\n19. Other investigator-deemed ineligibility.","ALL","30 Years","80 Years",{"count":47,"type":48},500,"ESTIMATED","OBSERVATIONAL","GROW-ICAS (Gut microBiota and prOgnostic Outcomes in IntraCranial Arterial Stenosis) is a prospective observational cohort study that enrolls patients with intracranial arterial stenosis to investigate the correlations between their gut microbiota, metabolomic, and transcriptomic profiles and three key clinical domains: functional outcomes, vascular plaque imaging characteristics, and post-stroke non-motor dysfunctions (including cognitive impairment, depression, anxiety, and fatigue).",[52],"Intracranial Artery Stenosis",[54,55],"intracranial artery stenosis","Gut Microbiota","2025-07-17",{"date":58,"type":59},"2025-07-25","ACTUAL",{"date":61,"type":59},"2025-06-01",{"date":63,"type":48},"2028-12-31",{"name":5,"class":6},1]