[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541567":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":39,"locations":44,"responsibleParty":77,"collaborators":80,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":26,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":26,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":26,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Idiopathic Calcium Oxalate Kidney Stone Patients","EXPERIMENTAL","Low and High oxalate fixed diets. Soluble oxalate absorption test.",[13,14,15],"Dietary Supplement: Low-oxalate diet","Dietary Supplement: High-oxalate diet","Other: soluble oxalate gut absorption test",{"label":17,"type":18,"description":11,"interventionNames":19},"Healthy non-kidney stone forming individuals","ACTIVE_COMPARATOR",[13,14,15],[21,27,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Low-oxalate diet","4 days of fixed eucaloric diet with low oxalate (\\\u003C60 mg\u002Fday), normal calcium content (600-1000 mg\u002Fday)",[17,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"High-oxalate diet","4 days of fixed eucaloric diet with moderately high oxalate (250-300 mg\u002Fday), normal calcium content (600-1000 mg\u002Fday)",[17,9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"soluble oxalate gut absorption test","Oral ingestion of 13C2-oxalate and sucralose.",[17,9],[36],{"name":37,"affiliation":5,"role":38},"Sonia Fargue, PhD","PRINCIPAL_INVESTIGATOR",[40],{"name":37,"role":41,"phone":42,"phoneExt":26,"email":43},"CONTACT","2059756932","sfargue@uabmc.edu",[45,66],{"facility":5,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-86.80249,33.52066,{"lat":56,"lon":55},[59,62,65],{"name":37,"role":41,"phone":60,"phoneExt":26,"email":61},"205-9756932","kidneystone@uabmc.edu",{"name":63,"role":41,"phone":64,"phoneExt":26,"email":61},"Research Coordinator","205-9345712",{"name":37,"role":38,"phone":26,"phoneExt":26,"email":26},{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":50,"countryCode":51,"cosmosGeoPoint":72,"geoPoint":76,"contacts":26},"UTSW","ACTIVE_NOT_RECRUITING","Dallas","Texas","75390",{"type":53,"coordinates":73},[74,75],-96.80667,32.78306,{"lat":75,"lon":74},{"type":38,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Sonia Fargue","Assistant Professor",[81,83],{"name":82,"class":6},"University of Texas Southwestern Medical Center",{"name":84,"class":85},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100541567","gut-oxalate-absorption-in-calcium-oxalate-stone-disease-100541567",false,"NCT06331546","Gut Oxalate Absorption in Calcium Oxalate Stone Disease","Gastrointestinal Oxalate Absorption in Calcium Oxalate Stone Disease","Inclusion Criteria:\n\n* age 18-70 yrs\n* Body Mass Index \\> 18.5 kg\u002Fm2\n* Normal fasting serum electrolytes on comprehensive metabolic profile\n* Willing to ingest fixed diets\n* Willing to stop supplements (vitamins including vitamin C, calcium (citrate or carbonate) and other minerals, herbal supplements, nutritional aids, probiotics) for 2 weeks before start and during study.\n* For stone formers: first time or recurrent Calcium Oxalate stone former. Composition of most recent stone ≥ 50% calcium oxalate if available, uric acid component \\\u003C20%\n\nExclusion Criteria:\n\n* Chronic Kidney Disease stage 4-5\n* Primary hyperoxaluria, Enteric (secondary) hyperoxaluria\n* Liver, bowel, endocrine or renal diseases (other than idiopathic Calcium Oxalate kidney stones) or any other condition that may influence the absorption, transport or urinary excretion of ions, which will compromise the interpretation of results, including: Cystic fibrosis, Celiac disease, Cystinuria, Uric acid stone former, Nephrotic syndrome, Sarcoidosis, Renal tubular acidosis, Primary hyperparathyroidism, Neurogenic bladder, Urinary diversion, Chronic diarrhea, Bariatric surgery, Inflammatory bowel disease\n* Pregnancy or breast-feeding\n* Incompatible dietary requirements with the study, food allergies or intolerance to any of the foods in study menus\n* Active malignancy or treatment for malignancy within 12 months prior to screening\n* Utilization of immunosuppressive medication\n* Uncontrolled hypertension or diabetes\n* Diabetes type 1\n* Chronic NSAID use",true,"ALL","18 Years","70 Years",{"count":98,"type":99},80,"ESTIMATED","INTERVENTIONAL",[102],"NA","The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate.\n\nThe study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones.\n\nParticipants will\n\n* ingest fixed diets containing low and moderately high amounts of oxalate for 5 days at a time\n* ingest a soluble form of oxalate and sugar preparations to test gut permeability\n* collect urine, blood, stool and breath sample during the fixed diets and the soluble oxalate test",[105,106,107,108,109,110,111,112,113],"Kidney Stone","Kidney Calculi","Urolithiasis","Urolithiasis, Calcium Oxalate","Nephrolithiasis","Nephrolithiasis, Calcium Oxalate","Oxalate Urolithiasis","Oxaluria","Healthy","2026-05-27",{"date":116,"type":117},"2026-05-28","ACTUAL",{"date":119,"type":117},"2024-04-17",{"date":121,"type":99},"2031-12-31",{"name":5,"class":6},2]