[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622116":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":38,"centralContacts":42,"locations":31,"responsibleParty":48,"collaborators":31,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":31,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":31,"enrollmentInfo":61,"targetDuration":31,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":31,"overallStatus":70,"whyStopped":31,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":31},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo Group","PLACEBO_COMPARATOR","Placebo",[13],"Other: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Low-Dose AST Group","EXPERIMENTAL","6 mg\u002Fd Astaxanthin (Haematococcus pluvialis)",[19],"Dietary Supplement: Low-Dose AST",{"label":21,"type":16,"description":22,"interventionNames":23},"High-Dose AST Group","12 mg\u002Fd Astaxanthin (Haematococcus pluvialis)",[24],"Dietary Supplement: High-Dose AST",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DIETARY_SUPPLEMENT","Low-Dose AST","Low-Dose AST Group:6 mg\u002Fd Astaxanthin (Haematococcus pluvialis)",[15],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"High-Dose AST","High-Dose Group: 12 mg\u002Fd Astaxanthin (Haematococcus pluvialis)",[21],{"type":6,"name":11,"description":11,"armGroupLabels":37,"otherNames":31},[9],[39],{"name":40,"affiliation":5,"role":41},"Linhong Yuan, Doctor","PRINCIPAL_INVESTIGATOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":31,"email":47},"Chen Miao","CONTACT","+86 13261666004","miaochen0243@163.com",{"type":41,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Miao Chen","Doctoral Student","100622116","haematococcus-pluvialis-astaxanthin-for-brain-aging-100622116",false,"NCT07379437","Haematococcus Pluvialis Astaxanthin for Brain Aging","Effects and Mechanism of Haematococcus Pluvialis Astaxanthin on Inhibiting Brain Aging Through Improving Mitochondrial Function","Inclusion Criteria:\n\nCognitive functionally normal elderly individuals aged 50 years or older with baseline MoCA scores near the borderline for mild cognitive impairment (MCI); subjects reporting age-related forgetfulness; community-dwelling residents who can cooperate with the research team to complete the intervention study.\n\nExclusion Criteria:\n\nIndividuals with hearing or language expression impairments that hinder communication; those with severe cardiovascular, cerebrovascular, hepatic, renal, or other organ diseases, or malignant tumors; individuals who have been taking astaxanthin or other antioxidant dietary supplements within the past month; those who have recently used medications that may affect neurological function; and individuals who are unable to undergo cognitive function assessment or refuse to sign an informed consent form.",true,"ALL","50 Years",{"count":62,"type":63},120,"ESTIMATED","INTERVENTIONAL",[66],"NA","We recruit community-dwelling older adults aged 50 and above for a 6-month intervention. Participants are divided into three groups:\n\nPlacebo Group, Low-Dose Group ( 6 mg\u002Fd Haematococcus pluvialis Astaxanthin), High-Dose Group (12 mg\u002Fd Haematococcus pluvialis Astaxanthin).\n\nPeripheral blood samples and Other tests are collected at baseline, 3 months, and 6 months to measure mitochondrial function and oxidative stress levels.\n\nAssessments include: 1.Cognitive \\& Neurophysiological Assessment: Using the MoCA (Montreal Cognitive Assessmentscale) and ERP (specifically P300) monitoring. 2.Brain Imaging: MRI (Magnetic resonance imaging) is used to analyze changes in brain function. 3.Metabolomics: A series of laboratory techniques are used to analyze routine metabolic indices, plasma astaxanthin, mitochondrial function, oxidative stress markers, and cognition-related neurobiomarkers.",[69],"Brain Aging","NOT_YET_RECRUITING","2026-01-27",{"date":73,"type":74},"2026-01-30","ACTUAL",{"date":76,"type":63},"2026-05-01",{"date":78,"type":63},"2027-02-01",{"name":5,"class":6}]