[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639329":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":32,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":32,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":32,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":87,"whyStopped":32,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Calgary","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Eccentric hamstring exercise","EXPERIMENTAL","All participants will complete a 12-week supervised lower limb strengthening program focused on eccentric hamstring loading. Participants will complete two training sessions per week with at least 48 hours between training sessions. Multiple classes will be offered each week to increase participation opportunity, with morning classes (8-9am) and evening classes (6-7pm) being offered on Mondays and Thursdays. Each class will be led by the same trained kinesiologist and cover the same training protocol within a given week, regardless of the day or time.",[13],"Behavioral: Progressive resistance exercise with an emphasis on eccentric hamstring loading.",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Progressive resistance exercise with an emphasis on eccentric hamstring loading.","The exercise intervention consists of a 12-week supervised lower limb strengthening program focused on eccentric hamstring loading. This program is adapted from a lower limb progressive resistance training protocol that was well-tolerated and effective in people with HSD\u002FhEDS. Each exercise session will start with a 10-minute aerobic warm up. This will be followed by the lower limb strengthening exercises, and a 5-minute aerobic cooldown. The lower limb exercises will include forward lunges and seated machine weights (leg press, leg extension, leg curl, calf raise). At weeks 6-11, eccentric hamstring loading will be initiated by utilizing the 2:1 technique of two limbs performing concentric action at once and then a single limb performing the eccentric action in a seated leg curl machine. This is an established eccentric loading protocol for the hamstring muscle group.",[9],[21,22,23],"Exercise","Progressive Resistance Training","Eccentric Exercise",[25],{"name":26,"affiliation":5,"role":27},"Ranita Manocha","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":32,"email":33},"CONTACT","4039444224",null,"bettermobilitylab@ucalgary.ca",[35],{"facility":36,"status":32,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"University of Calgary - Foothills Campus","Calgary","Alberta","T2N 4N1","Canada","CA",{"type":43,"coordinates":44},"Point",[45,46],-114.08529,51.05011,{"lat":46,"lon":45},[49,51],{"name":26,"role":30,"phone":32,"phoneExt":50,"email":33},"403 944 4224",{"name":52,"role":27,"phone":32,"phoneExt":32,"email":32},"Ranita Manocha, MD, MSc",{"type":27,"investigatorFullName":26,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Doctor of Medicine","100639329","hamstring-strengthening-in-hypermobile-conditions-100639329",false,"NCT07626957","Hamstring Strengthening in Hypermobile Conditions","Effects and Feasibility of Eccentric Hamstring Strengthening in Hypermobility Spectrum Disorders and Hypermobile Ehlers-Danlos Syndrome","Inclusion Criteria:\n\n* Reported diagnosis of HSD or hEDS by a physician\n* Meet the 2017 International Diagnostic Criteria for HSD and hEDS\n* Clearance to participant in exercise participation, determined using the Get Active Questionnaire\n\nExclusion Criteria:\n\n* Other acquired or hereditary connective tissue disorder (i.e., rheumatoid arthritis, Marfan syndrome, etc.)\n* Currently experiencing daily knee pain\n* Prior knee injury or surgery\n* Intra-articular knee injection in the last 12 months\n* Currently pregnant","FEMALE","18 Years","55 Years",{"count":66,"type":67},20,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS). The main questions it aims to answer are:\n\n* Does hamstring strengthening reduce the looseness of the knee joint in HSD\u002FhEDS?\n* Does hamstring strengthening improve clinical outcomes like pain in people living with HSD\u002FhEDS?\n\nParticipants will:\n\n* Attend two exercise classes per week for 12 weeks.\n* Visit the laboratory every 4-6 weeks for testing.",[73,74,75,76],"Hypermobile EDS (hEDS)","Hypermobile Ehlers-Danlos Syndrome","Hypermobile Spectrum Disorder","Hypermobility Type Ehlers-Danlos Syndrome",[21,78,79,80,81,82,83,74,84,85,86],"Female","Knee","Joint Laxity","Hypermobility","Joint Stiffness","Ehlers-Danlos Syndrome","Hypermobility Spectrum Disorders","strengthening","eccentric","NOT_YET_RECRUITING","2026-05-29",{"date":90,"type":91},"2026-06-04","ACTUAL",{"date":93,"type":67},"2026-06-01",{"date":95,"type":67},"2027-08-01",{"name":5,"class":6},1]