[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587227":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":54,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Study group",null,"The study group will consist of 20 healthy non-smokers, with BMIs between 18-30 kg·m-2, free of cardiopulmonary diseases.\n\nSubjects will wear multiple pulse oximeter devices to measure arterial oxygen saturation (SpO2).\n\nTwo fingers of each hand will be be equipped with identical FDA approved devices from two different commercial manufacturers.\n\nThe third finger of each hand be equipped with a Mayo device developed by the SPPDG program for use by the US Military.\n\nTwo wrist worn PPG-equipped \"watches\" (Garmin Fenix and the Mayo Clinic Developed SPPDG Watch) will be worn on each arm. One will be placed in the normal watch position (dorsal forearm) where pigmentation will generally be the darkest; the other will be placed on the volar forearm where pigmentation is generally less.\n\nSubjects will also have an indwelling catheter placed in the brachial artery to collect samples for blood gases.",[13,14,15],"Procedure: Finger hyperperfusion via adenosine","Procedure: Finger hypoperfusion via by norepinephrine","Procedure: Baseline hypoxic test",[17,22,26],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"PROCEDURE","Finger hyperperfusion via adenosine","Subjects will be fitted with a mouthpiece and\u002For facemask to systematically reduce the fraction of inspired oxygen (FiO2) they breathe, starting with room air (21% O2), and then progressive hypoxic mixtures of 18%, 15%, 12%, and 10% FiO2 in sequence for five minutes each.\n\nBlood flow to the hand downstream from the brachial catheter will be increased by brachial artery infusions of adenosine administered at 6.25 mcg\u002F100ml tissue per minute for 30 minutes into the brachial artery to increase blood flow by 5 to 10-fold.",[9],{"type":18,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Finger hypoperfusion via by norepinephrine","Subjects will be fitted with a mouthpiece and\u002For facemask to systematically reduce the fraction of inspired oxygen (FiO2) they breathe, starting with room air (21% O2), and then progressive hypoxic mixtures of 18%, 15%, 12%, and 10% FiO2 in sequence for five minutes each.\n\nBlood flow to the hand downstream from the brachial catheter will be decreased to \\~25% of baseline, by infusing norepinephrine at 4 ng\u002F100ml of tissue per minute for 30 minutes.",[9],{"type":18,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Baseline hypoxic test","Subjects will be fitted with a mouthpiece and\u002For facemask to systematically reduce the fraction of inspired oxygen (FiO2) they breathe, starting with room air (21% O2), and then progressive hypoxic mixtures of 18%, 15%, 12%, and 10% FiO2 in sequence for five minutes each.",[9],[31],{"name":32,"affiliation":5,"role":33},"Michael Joyner, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Nancy Meyer","CONTACT","5072550913","meyer.nancy2@mayo.edu",[41],{"facility":42,"status":10,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":10},"Mayo Clinic Department of Anesthesiology","Rochester","Minnesota","55902","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-92.4699,44.02163,{"lat":52,"lon":51},{"type":33,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Michael J. Joyner, M.D.","Principal Investigator","100587227","hand-perfusion-and-pulse-oximetry-performance-100587227",false,"NCT06925646","Hand Perfusion and Pulse Oximetry Performance","Inclusion Criteria:\n\n* Healthy adult men and women of all races and ethnic backgrounds recruited from faculty and staff of the Mayo Medical Center and from Rochester, MN and surrounding communities.\n* Equal number of male and female participants to address potential sex differences in physiology.\n* We will intentionally recruit subjects with dark skin because of the issues surrounding accuracy of pulse oximetry and skin tone.\n* Non-smokers\n* BMIs between 18-30 kg·m-2.\n* Female subjects will be non-pregnant.\n* Free of cardiopulmonary diseases or other conditions and\u002For taking medications that might affect pulse oximeter-based estimates of arterial saturation.\n* All inclusion and exclusion criteria are at the discretion of the Principal Investigator.\n* At least 8 of the subjects will have Fitzpatrick Skin Type of IV to VI.\n\nExclusion Criteria:\n\n• Children under the age of 18 will not be studied. We will exclude children less than 18 years of age because they are unable to give consent, and because these studies are non-therapeutic.",true,"ALL","18 Years","65 Years",{"count":68,"type":69},20,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to compare oxygen saturation measurement readings from manufactured pulse oximetry devices to the oxygen saturation measurements of arterial blood samples drawn at the same time of measurements.",[73],"Oxygen Saturation","NOT_YET_RECRUITING","2026-03-11",{"date":77,"type":78},"2026-03-13","ACTUAL",{"date":80,"type":69},"2026-09-01",{"date":82,"type":69},"2028-10-01",{"name":5,"class":6},1]