[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100332629":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":48,"responsibleParty":94,"collaborators":97,"id":101,"slug":102,"hasResults":103,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":23,"eligibilityCriteria":107,"healthyVolunteers":103,"sex":108,"minAge":109,"maxAge":23,"enrollmentInfo":110,"targetDuration":23,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":51,"whyStopped":23,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Transplantation\u002FReplantation Patients","ACTIVE_COMPARATOR","Can plateaued hand function in hand transplantation patients\u002Fhand replantation patients in the chronic stage of recovery be facilitated by use of bi-hemispheric transcranial direct current stimulation (tDCS) combined with modified Constraint Induced Movement Therapy (CIMT)?",[13,14],"Device: Transcranial Direct Current Stimulation","Behavioral: Modified Constraint Induced Movement Therapy",{"label":16,"type":10,"description":17,"interventionNames":18},"Nerve Injury Patients active","Can plateaued hand function in peripheral nervous system injuries in the chronic stage of recovery be facilitated by use of bi-hemispheric transcranial direct current stimulation (tDCS) combined with modified Constraint Induced Movement Therapy (CIMT)?",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Actigraphy Testing","NO_INTERVENTION","We will acquire a set of actigraphy data from a group of hand transplant\u002Freplant patients and unilateral, adult amputees in order to evaluate typical patterns of limb use prior to hand transplantation and to investigate prosthesis utilization.",null,[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Transcranial Direct Current Stimulation","Transcranial direct current stimulation (tDCS) is a portable neurostimulation method that modulates cortical excitability. The technique involves placing two saline-soaked electrodes (anode and cathode) on the scalp and passing a small direct current (1.5 milliamps; mA) between them. Cortex underlying the anode is more easily excited due to lowered thresholds for depolarization of glutamatergic neurons, while thresholds are increased in neurons beneath the cathode, making them less excitable. Sham stimulation is easily implemented, and the technique can be effectively double-blinded.",[16,9],[31],"tDCS",{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"BEHAVIORAL","Modified Constraint Induced Movement Therapy","In CIMT, patients are required to wear a mitt that restricts use of the unaffected limb while they practice structured tasks and also engage in activities of daily living.",[16,9],[38],"CIMT",[40],{"name":41,"affiliation":5,"role":42},"Scott H Frey, Ph.D., Ed.M.","PRINCIPAL_INVESTIGATOR",[44],{"name":41,"role":45,"phone":46,"phoneExt":23,"email":47},"CONTACT","573-882-4572","freylab@missouri.edu",[49,68,80],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Christine Kleinert Institute for Hand & Microsurgery","RECRUITING","Louisville","Kentucky","40202","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-85.75941,38.25424,{"lat":61,"lon":60},[64],{"name":65,"role":45,"phone":66,"phoneExt":23,"email":67},"Christina Kaufman, Ph.D.","502-562-0390","ckaufman@cmki.org",{"facility":69,"status":51,"city":70,"state":71,"zip":72,"country":55,"countryCode":56,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"University of Missouri","Columbia","Missouri","65211",{"type":58,"coordinates":74},[75,76],-92.33407,38.95171,{"lat":76,"lon":75},[79],{"name":41,"role":45,"phone":46,"phoneExt":23,"email":47},{"facility":81,"status":51,"city":82,"state":71,"zip":83,"country":55,"countryCode":56,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Washington University School of Medicine","St Louis","63110",{"type":58,"coordinates":85},[86,87],-90.19789,38.62727,{"lat":87,"lon":86},[90],{"name":91,"role":45,"phone":92,"phoneExt":23,"email":93},"Amy Moore, MD","314-454-4894","mooream@wustl.edu",{"type":42,"investigatorFullName":95,"investigatorTitle":96,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Scott H Frey, PhD","Miller Family Professor of Cognitive Neuroscience",[98,99],{"name":81,"class":6},{"name":100,"class":6},"Christine M. Kleinert Institute for Hand and Microsurgery","100332629","harnessing-neuroplasticity-to-enhance-functional-recovery-during-chronic-recovery-from-upper-extremity-nerve-repair-100332629",false,"NCT03610763","Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair","Harnessing Neuroplasticity to Enhance Functional Recovery in Allogeneic Hand Transplant and Heterotopic Hand Replant Recipients","Inclusion Criteria:\n\n* Individuals whom have received a unilateral allogeneic transplantation proximal to the wrist and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).\n* Individuals whom have undergone a complete amputation the hand between the wrist and elbow followed by successful re-attachment and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).\n* Individuals whom have undergone repairs of the median, ulnar, or other related or nearby nerve(s) following complex volar forearm lacerations or other injuries between the distal wrist crease and the flexor musculotendinous junctions. Individuals must be at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).\n\nExclusion Criteria:\n\n* Individuals with significant\u002Fsevere brain trauma\n* Serious psychiatric conditions\n* Chronic or severe neurological conditions.\n* Current pregnancy\n* History of seizures or unexplained loss of consciousness\n* Metallic implants above the chest\n* Certain implanted medical devices.","ALL","18 Years",{"count":111,"type":112},180,"ESTIMATED","INTERVENTIONAL",[115],"NA","This study adopts a strategy that has arisen from basic neuroscience research on facilitating adaptive brain plasticity and applies this to rehabilitation to improve functional recovery in peripheral nervous system injuries (including hand transplantation, hand replantation, and surgically repaired upper extremity nerve injuries). The technique involves combining behavioral training with transcranial direct current stimulation (tDCS)-a non-invasive form of brain stimulation capable of facilitating adaptive changes in brain organization.",[118,119,120],"Hand Transplantation","Peripheral Nerve Injuries","Neurologic Rehabilitation",[122,27,123,124,125,126,127,119,31,38],"Rehabilitation Neuroscience","Rehabilitation Therapy","Neuroplasticity","Transplantation","Hand Therapy","Constraint Induced Movement Therapy","2024-06-11",{"date":130,"type":131},"2024-06-12","ACTUAL",{"date":133,"type":131},"2018-08-15",{"date":135,"type":112},"2025-06-01",{"name":5,"class":6},3]