[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633629":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":15,"centralContacts":24,"locations":34,"responsibleParty":50,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":7,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":71,"studyType":72,"phases":7,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":37,"whyStopped":7,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Guven Health Group","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DRUG","Antiviral","Patients who take all antivirals recommended in the guidelines will be evaluated in the same group.",[14],"Nucleoz(t)ide antivirals",[16,20],{"name":17,"affiliation":18,"role":19},"Yaşar Bayındır","Guven Hospital","STUDY_DIRECTOR",{"name":21,"affiliation":22,"role":23},"cigdem Mermutluoglu","Dicle University, Medical Faculty","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":7,"email":29},"Cigdem Mermutluoglu","CONTACT","+905052252700","cigdemmermut@gmail.com",{"name":31,"role":27,"phone":32,"phoneExt":7,"email":33},"Mustafa Kemal Celen","+905336207022","mkcelen@hotmail.com",[35],{"facility":36,"status":37,"city":38,"state":7,"zip":39,"country":40,"countryCode":7,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Dicle University","RECRUITING","Diyarbakır","TR-21280","Turkey (Türkiye)",{"type":42,"coordinates":43},"Point",[44,45],40.21721,37.91363,{"lat":45,"lon":44},[48,49],{"name":26,"role":27,"phone":28,"phoneExt":7,"email":29},{"name":31,"role":27,"phone":32,"phoneExt":7,"email":33},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","Yaşar Bayındır, MD","Chief Physican",[55],{"name":56,"class":57},"SOUTHEAST NEUROLOGY AND INFECTIOUS DISEASES SOCIETY","UNKNOWN","100633629","hbv-reactivation-in-immunocompromised-patients-reant-study-100633629",false,"NCT07529171","HBV Reactivation in Immunocompromised Patients (REANT STUDY)","Management and Monitoring of HBV Reactivation in Immunocompromised Patients in Turkey (REANT STUDY)","Inclusion Criteria:\n\n* Aged 18 years or older\n* Positive for Anti-HBc IgG\n* Must be candidate for immunosuppressive therapy.\n\nExclusion Criteria:\n\n* Voluntary Withdrawal\n* Failure to attend follow-up visits","ALL","18 Years","80 Years",{"count":69,"type":70},490,"ESTIMATED","48 Months","OBSERVATIONAL","Background\u002FObjective: Comorbidities represent a critical risk factor in the prognosis of patients receiving immunosuppressive therapy. For patients with anti-HBc IgG positivity requiring Hepatitis B virus (HBV) prophylaxis, the long-term physiological impact of oral antivirals remains a concern. This study aims to prospectively monitor bone, renal, and metabolic dysfunctions associated with oral antiviral use and other systemic risk factors over a long-term period.\n\nMethods: The REANT Cohort is designed as a 4-year, multicenter prospective study. The cohort will consist of patients initiated on HBV prophylaxis due to immunosuppressive treatment. Participants will undergo regular longitudinal assessments to evaluate bone mineral density, renal filtration and tubular functions, and metabolic profiles. The interplay between antiviral therapy, baseline comorbidities, and long-term organ dysfunction will be analyzed.\n\nConclusion: The findings from the REANT Cohort are expected to provide robust evidence regarding the safety of long-term HBV prophylaxis and assist in the development of monitoring guidelines for immunosuppressed patients with latent HBV infection.",[75],"HBV",[77,78],"HBV reactivation","Immunosuppressive therapy","2026-04-09",{"date":81,"type":82},"2026-04-14","ACTUAL",{"date":84,"type":82},"2026-03-09",{"date":86,"type":70},"2029-12-31",{"name":52,"class":6},1]