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MRCP",{"facility":646,"status":49,"city":647,"state":10,"zip":648,"country":471,"countryCode":472,"cosmosGeoPoint":649,"geoPoint":653,"contacts":654},"University Hospitals Plymouth NHS Trust","Plymouth","PL6 5FP",{"type":55,"coordinates":650},[651,652],-4.14305,50.37153,{"lat":652,"lon":651},[655,659],{"name":656,"role":40,"phone":657,"phoneExt":10,"email":658},"Elizabeth Cray","01752 439636","elizabethcray@nhs.net",{"name":660,"role":36,"phone":10,"phoneExt":10,"email":10},"Daniel Lashley, MBBS",{"type":36,"investigatorFullName":662,"investigatorTitle":663,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Edward Wild","Dr",[665],{"name":666,"class":6},"CHDI Foundation, Inc.","100274686","hdclarity-a-multi-site-cerebrospinal-fluid-collection-initiative-to-facilitate-therapeutic-development-for-huntingtons-disease-100274686",false,"NCT02855476","HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease","HDClarity","Inclusion Criteria:\n\n* Age (18-75 years controls, early\u002Flate premanifest HD and incomplete penetrance HD, 21-75 years early\u002Fmoderate\u002Fadvanced manifest HD, ≥11 years juvenile HD)\n* Enroll HD participant\n* Capable of consenting or have a legal representative (parent\u002Fguardian for juveniles)\n* Capable of complying with study procedures\n* All participants other than family and community controls must have had a genetic test for HD\n\nExclusion Criteria:\n\n* Drug trial within 30 days of any sampling visit\n* Changes in medication (antidepressant, psychoactive, psychotropic or other medications or nutraceuticals used to treat HD within 30 days)\n* Antiplatelet or anticoagulant therapy within 14 days\n* Significant comorbidity\n* Needle phobia, headache, spinal surgery \u002F deformity\n* Clotting or bruising disorder\n* Screening blood test abnormalities \\>10% outside normal range\n* Drug \u002F alcohol abuse\n* Positive urine pregnancy test at any screening or sampling visit for females of childbearing potential\n* Predictable non compliance or unwillingness\n* Serious adverse event related to HDClarity study procedures or any lumbar puncture procedure performed for any reason in the previous 30 days",true,"ALL","11 Years","75 Years",{"count":679,"type":680},2500,"ESTIMATED","OBSERVATIONAL","HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.",[684],"Huntington's Disease","2026-04-24",{"date":687,"type":688},"2026-04-27","ACTUAL",{"date":690,"type":688},"2017-01-01",{"name":5,"class":6},40]