[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621208":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":38,"locations":47,"responsibleParty":61,"collaborators":43,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":43,"enrollmentInfo":73,"targetDuration":43,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":90,"whyStopped":43,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Population Health Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Arm","EXPERIMENTAL","Head of bed position of 0-degrees",[13],"Other: Head of bed position of 0-degrees",{"label":15,"type":6,"description":16,"interventionNames":17},"Control Arm","Head of bed position of 30-degrees or greater",[18],"Other: Head of bed position of 30-degrees or greater",[20,25],{"type":6,"name":11,"description":21,"armGroupLabels":22,"otherNames":23},"Flat position with the HoB at 0° elevation for a continuous 24-hour period. Turning to the side (left or right) is permitted, as long as there is no head elevation.",[9],[24],"HoB position of 0-degrees",{"type":6,"name":16,"description":26,"armGroupLabels":27,"otherNames":28},"Semi-recumbent position with the HoB to at least 30 degrees for a continuous 24-hour period.\n\nHead and torso must remain elevated at 30 degrees or higher, using the hospital bed's positioning system.",[15],[29,30,31],"HoB position of >= 30-degrees","HoB position of greater than or equal to 30-degrees","HoB position of ≥ 30-degrees",[33,36],{"name":34,"affiliation":5,"role":35},"Aristeidis Katsanos, MD","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":5,"role":35},"Mike Sharma, MD",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Samantha Block, BSc","CONTACT","905-521-2100",null,"hobit@phri.ca",{"name":46,"role":41,"phone":42,"phoneExt":43,"email":44},"Amanda Taylor, BSc",[48],{"facility":49,"status":43,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":43},"Hamilton General Hospital","Hamilton","Ontario","L8L 2X2","Canada","CA",{"type":56,"coordinates":57},"Point",[58,59],-79.84963,43.25011,{"lat":59,"lon":58},{"type":62,"investigatorFullName":43,"investigatorTitle":43,"investigatorAffiliation":43,"oldNameTitle":43,"oldOrganization":43},"SPONSOR","100621208","head-of-bed-after-ischemic-stroke-thrombectomy-hobit-100621208",false,"NCT07367633","Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)","A Pragmatic, Multicentre, Adaptive, Prospective, Open-label, Blinded Endpoint Randomized Clinical Trial Assessing the Impact of Head-of-bed Positioning at 0-degrees Versus 30-degrees or More on Functional Recovery Following Endovascular Thrombectomy for Anterior Circulation Large Vessel Occlusion Stroke.","HoBIT","Inclusion Criteria:\n\n* Age 18 years or older on the date of randomization\n* Endovascular thrombectomy (EVT) for large vessel occlusion (LVO) in the anterior circulation, according to current guidelines and local standards of clinical care. The definition of LVO may include the intracranial segment of the internal carotid artery (ICA), and\u002F or the M1 segment (proximal, mid, distal) of the middle cerebral artery (M1-MCA), and\u002F or the proximal M2 segment of the MCA (M2-MCA)\n* Capable of giving signed informed consent either independently, or by a legally authorized representative (LAR), or via a deferred consent process approved by the relevant ethics committee, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.\n\nExclusion Criteria:\n\n* Mechanical ventilatory support for acute medical condition prior to procedure (i.e. required for reasons other than procedure)\n* Symptomatic congestive heart failure, chronic obstructive pulmonary disease, or any other medical condition that would make either HoB position inappropriate for patient care in the judgement of the investigator.\n* Any condition, such as but not limited to, agitation\u002F delirium or severe nausea\u002F vomiting, that, in the view of the investigator, is expected to significantly impede maintaining the assigned HoB\n* Any condition with life expectancy of less than 3 months\n* Inability to randomize within 1 hour from the end of the EVT","ALL","18 Years",{"count":74,"type":75},2240,"ESTIMATED","INTERVENTIONAL",[78],"NA","Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain. However, half of the patients undergoing EVT to remove the clot from a brain vessel still face lasting disabilities or even die within three months.\n\nThe investigators of the HoBIT trial are trying to find out if the position of the head of bed improves recovery in patients who undergo EVT after suffering from a stroke.\n\nThe purpose of this study is to establish the benefit of head of bed positioning at 0-degrees compared with 30-degrees or more after EVT for improving functional outcomes in adults that suffer from a stroke.",[81,82,83],"Large Vessel Occlusion","Stroke","Ischemic Stroke",[85,86,87,88,89],"head of bed","stroke","large vessel occlusion","endovascular thrombectomy","EVT","NOT_YET_RECRUITING","2026-02-03",{"date":93,"type":94},"2026-02-05","ACTUAL",{"date":96,"type":75},"2026-03",{"date":98,"type":75},"2028-12",{"name":5,"class":6},1]