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Hospital","02115",{"type":33,"coordinates":136},[123,124],{"lat":124,"lon":123},[139,142],{"name":140,"role":20,"phone":7,"phoneExt":7,"email":141},"Jonathan Greenberg","jonathan.greenberg@childrens.harvard.edu",{"name":143,"role":16,"phone":7,"phoneExt":7,"email":7},"Manuela Cernadas, MD",{"facility":145,"status":26,"city":146,"state":147,"zip":148,"country":30,"countryCode":31,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"University of Michigan","Ann Arbor","Michigan","48109",{"type":33,"coordinates":150},[151,152],-83.74088,42.27756,{"lat":152,"lon":151},[155],{"name":156,"role":16,"phone":7,"phoneExt":7,"email":7},"Shijing Jia, MD",{"facility":158,"status":26,"city":159,"state":160,"zip":161,"country":30,"countryCode":31,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"University of 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MS",{"type":16,"investigatorFullName":282,"investigatorTitle":283,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Traci Kazmerski","Assistant Professor",[285,287],{"name":286,"class":6},"Cystic Fibrosis Foundation",{"name":288,"class":289},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100538865","health-outcomes-of-parents-with-cystic-fibrosis-aim-2-100538865",false,"NCT06296394","Health Outcomes of Parents With Cystic Fibrosis-Aim 2","HOPeCF","Inclusion Criteria:\n\n* Diagnosed with cystic fibrosis via sweat test or genotype analysis\n* Became a first-time parent (including foster parent, step parent, adoptive parent, or legal guardian) to a child under 5 years of age within the last 180 days\n\nExclusion Criteria:\n\n* Undergone a lung transplant\n* Does not speak\u002Fread English or Spanish","ALL","18 Years",{"count":300,"type":301},146,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this observational prospective study is to determine the health impact of parenthood on United States (US) people with CF in the era of CF transmembrane regulator protein (CFTR) modulators. The investigators will collect physical and mental health data to comprehensively evaluate the impact of parenthood in CF with widespread highly effective CFTR modulator use. The main hypotheses this study aims to examine are:\n\nH1: Parents with CF and moderate-to-severe depression have more rapid change in ppFEV1 (percent predicted forced expiratory volume in one second) versus those with mild or no depression.\n\nH2: Parents with CF who have more parental responsibility and\u002For stress have more rapid ppFEV1 (percent predicted forced expiratory volume in one second) change than those with less responsibility\u002Fstress\n\nH3: Parents using CFTR modulators have decreased ppFEV1 (percent predicted forced expiratory volume in one second) change versus those not using CFTR modulators\n\nParticipants will complete quarterly surveys during the first year of parenthood and biannual surveys, thereafter, using the computer-based survey system on an iPad protected for infection control or via personal device or computer via emailed survey link.",[306,307],"Cystic Fibrosis","Parenthood Status",[309,310,311],"cystic fibrosis","parenthood","highly effective modulator therapy","2025-11-06",{"date":314,"type":315},"2025-11-10","ACTUAL",{"date":317,"type":315},"2024-05-29",{"date":319,"type":301},"2031-02-01",{"name":5,"class":6},18]