[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607733":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":123,"collaborators":125,"id":132,"slug":133,"hasResults":134,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":134,"sex":140,"minAge":10,"maxAge":141,"enrollmentInfo":142,"targetDuration":10,"studyType":145,"phases":10,"briefSummary":146,"conditions":147,"keywords":154,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":173},{"fullName":5,"class":6},"Imperial College London","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"General Prematurity",null,"Includes all babies born \\\u003C30 weeks gestation, who did not develop NEC during their hospital stay, and their parents and siblings.",{"label":13,"type":10,"description":14,"interventionNames":10},"General Prematurity + Necrotising Enterocolitis (NEC)","Includes all babies born \\\u003C30 weeks gestation, who also developed and recovered from NEC during their hospital stay, and their parents and siblings.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Joe Montebello, MSc","CONTACT","+442075947271","j.montebello@imperial.ac.uk",[22,42,56,70,84,95,109],{"facility":23,"status":24,"city":25,"state":26,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Norfolk and Norwich University Hospital","RECRUITING","Norwich","Norfolk","United Kingdom","UK",{"type":30,"coordinates":31},"Point",[32,33],1.29834,52.62783,{"lat":33,"lon":32},[36,40],{"name":37,"role":18,"phone":38,"phoneExt":10,"email":39},"Jasmine Myhill","01603 286286","jasmine.myhill@nnuh.nhs.uk",{"name":37,"role":41,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":43,"status":24,"city":44,"state":10,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":45,"geoPoint":49,"contacts":50},"University Hospital Coventry","Coventry",{"type":30,"coordinates":46},[47,48],-1.51217,52.40656,{"lat":48,"lon":47},[51,55],{"name":52,"role":18,"phone":53,"phoneExt":10,"email":54},"Arthi Lakshmanan","+442476966201","Uhcw.Research5@uhcw.nhs.uk",{"name":52,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":57,"status":24,"city":58,"state":10,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Liverpool Women's Hospital","Liverpool",{"type":30,"coordinates":60},[61,62],-2.97794,53.41058,{"lat":62,"lon":61},[65,69],{"name":66,"role":18,"phone":67,"phoneExt":10,"email":68},"Jo Windrow","+441517024084","joanne.windrow@lwh.nhs.uk",{"name":66,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":71,"status":24,"city":72,"state":10,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Chelsea & Westminster Hospital","London",{"type":30,"coordinates":74},[75,76],-0.12574,51.50853,{"lat":76,"lon":75},[79,83],{"name":80,"role":18,"phone":81,"phoneExt":10,"email":82},"Chris Gale","+442033153519","christopher.gale@imperial.ac.uk",{"name":80,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":85,"status":24,"city":72,"state":10,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":86,"geoPoint":88,"contacts":89},"Imperial College Healthcare NHS Trust (St Mary's Hospital, Paddington)",{"type":30,"coordinates":87},[75,76],{"lat":76,"lon":75},[90,94],{"name":91,"role":18,"phone":92,"phoneExt":10,"email":93},"Batia Gourin","020 3312 6666","b.gourin@nhs.net",{"name":91,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":96,"status":24,"city":97,"state":10,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"John Radcliffe Hospital","Oxford",{"type":30,"coordinates":99},[100,101],-1.25596,51.75222,{"lat":101,"lon":100},[104,108],{"name":105,"role":18,"phone":106,"phoneExt":10,"email":107},"Cath Bailey","0300 304 7777","cath.bailey@ouh.nhs.uk",{"name":105,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":110,"status":24,"city":111,"state":10,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Queen Alexandra Hospital","Portsmouth",{"type":30,"coordinates":113},[114,115],-1.09125,50.79899,{"lat":115,"lon":114},[118,122],{"name":119,"role":18,"phone":120,"phoneExt":10,"email":121},"Ali LePoidevin","023 9228 6000","alison.lepoidevin@porthosp.nhs.uk",{"name":119,"role":41,"phone":10,"phoneExt":10,"email":10},{"type":124,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[126,128,130],{"name":127,"class":6},"University of Oxford",{"name":129,"class":6},"University of Leeds",{"name":131,"class":6},"University of Cape Town","100607733","health-related-quality-of-life-and-household-financial-and-wellbeing-impacts-of-prematurity-and-necrotising-enterocolitis-nec-100607733",false,"NCT07192393","Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising Enterocolitis (NEC).","Quantifying the Household Impact on Patient-Reported Outcomes and Costs Associated With the Care of Preterm Babies With and Without Necrotising Enterocolitis (NEC): A Study Alongside the Withholding Enteral Feeds Around Blood Transfusion (WHEAT) Trial","PREM-IMPACT","Inclusion Criteria:\n\n* Preterm birth \\\u003C30 gestational weeks\n\nExclusion Criteria:\n\n* Parent(s) of a preterm baby who died of necrotising enterocolitis (NEC)\n* Parent(s) unwilling or unable to provide written informed consent\n* Parent(s) and sibling(s) unable to understand English.","ALL","30 Weeks",{"count":143,"type":144},90,"ESTIMATED","OBSERVATIONAL","PREM-IMPACT is a UK-based observational study exploring how caring for a very premature baby-particularly one affected by necrotising enterocolitis (NEC)-impacts families over the first year after hospital discharge. NEC is a serious bowel disease that can occur in premature babies, often requiring surgery and prolonged hospitalisation.\n\nThis study runs alongside the WHEAT International Trial, which investigates whether pausing or continuing milk feeds during blood transfusions affects the risk of NEC in very preterm babies. PREM-IMPACT acts as a nested economic evaluation of the WHEAT Trial, helping to understand whether different feeding practices around transfusion offer good value for money from both the NHS and family perspective.\n\nPREM-IMPACT will collect detailed data on babies' health-related quality of life, as well as the financial, emotional, and social impact on parents and siblings. Families are recruited from neonatal units when their baby is ready to go home and complete questionnaires at three timepoints: 1) just before discharge, 2) six months later, and 3) twelve months later. Questionnaires cover health, wellbeing, healthcare use, and costs to the family (such as travel, time off work, or extra care needs). A dedicated research nurse based at the lead NHS site helps coordinate follow-up centrally.\n\nBy studying families of babies with and without NEC, this project aims to clarify the burden of prematurity and NEC on infant outcomes and family wellbeing. The results will inform future policy decisions, including whether pausing or continuing milk feeds during transfusion should be adopted in routine neonatal care.",[148,149,150,151,152,153],"Prematurity; Extreme","Prematurity; Decision Support","Necrotising Enterocolitis","Preterm","Preterm Birth","Preterm Infant Health",[155,156,157,158,159,160,151,161,162,163],"NEC","Cost-Effectiveness Analysis","Cost-Utility Analysis","Health-Related Quality of Life","HR-QoL","Prematurity","Health Economic Analysis","Financial Impact","Wellbeing","2026-03-27",{"date":166,"type":167},"2026-03-30","ACTUAL",{"date":169,"type":167},"2025-08-08",{"date":171,"type":144},"2027-10-31",{"name":5,"class":6},7]