[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558860":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":13,"locations":23,"responsibleParty":41,"collaborators":7,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":45,"sex":51,"minAge":52,"maxAge":7,"enrollmentInfo":53,"targetDuration":7,"studyType":56,"phases":7,"briefSummary":57,"conditions":58,"keywords":7,"overallStatus":26,"whyStopped":7,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"University Children's Hospital, Zurich","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"BEHAVIORAL","Interview","Interviews, presentation of questionnaires",[14,20],{"name":15,"role":16,"phone":17,"phoneExt":18,"email":19},"Helene Werner, PD, Dr","CONTACT","004144266","0","helene.werner@kispi.uzh.ch",{"name":21,"role":16,"phone":17,"phoneExt":18,"email":22},"Martina Huemer, Prof","martina.huemer@kispi.uzh.ch",[24],{"facility":25,"status":26,"city":27,"state":7,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Kinderspital Zürich","RECRUITING","Zurich","8008","Switzerland","CH",{"type":32,"coordinates":33},"Point",[34,35],8.55,47.36667,{"lat":35,"lon":34},[38],{"name":39,"role":16,"phone":40,"phoneExt":7,"email":19},"Helene Werner, PhD","+41442490",{"type":42,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100558860","health-related-quality-of-life-hrqol-in-classical-homocystinuria-cbs-deficiency-100558860",false,"NCT06556615","Health Related Quality of Life (HrQoL) in Classical Homocystinuria (CBS Deficiency)","Development and Validation of a Standardized Assessment Instrument for Health-related Quality of Life (HrQoL) in Patients With Classical Homocystinuria","CBS_HrQoL","Inclusion criteria\n\n* Patients with CBS deficiency from age 8 years\n* Parents of patient(s) \\\u003C 18 years with cognitive impairment\n* Parents of patients between age 4 and 7\n* Experts on CBS deficiency\n* Able to give informed consent as documented by signature\n\nExclusion criteria\n\n\\- Sufficient command of the German or the English language","ALL","8 Years",{"count":54,"type":55},80,"ESTIMATED","OBSERVATIONAL","Patients, parents of young \u002F handicapped patients, and experts will be interviewed to collect contents relevant for HrQoL in CBS deficiency. Based on these data, a questionnaire will be developed and tested for comprehensibility in patients and parents of young \u002F handicapped patients. A final questionnaire version will be tested for psychometric criteria including validity and reliability.",[59],"Homocystinuria","2025-04-09",{"date":62,"type":63},"2025-04-10","ACTUAL",{"date":65,"type":63},"2025-01-15",{"date":67,"type":55},"2025-09",{"name":5,"class":6},1]