[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639518":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":56,"collaborators":19,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":19,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":93,"whyStopped":19,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"New York University Abu Dhabi","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HEAL MS Lifestyle Intervention","EXPERIMENTAL","Participants first complete a 12-week observation period during which they maintain their usual lifestyle. This is followed by a 12-week HEAL MS lifestyle intervention targeting four domains: adaptive movement, anti-inflammatory nutrition, sleep optimization, and stress regulation. The movement component includes twice-weekly supervised online group exercise sessions using scalable functional exercises. The nutrition component provides personalized meal plans with two weeks of meal delivery to support adherence. Sleep and stress modules include circadian hygiene strategies, breathwork, and mindfulness practices. Participants track daily behaviors, wellbeing, and optional wearable data through a bilingual mobile application. Assessments including blood sampling, body composition, functional fitness testing, and questionnaires are conducted at baseline, pre-intervention, post-intervention, and three months post-intervention.",[13],"Other: Multi-Domain Lifestyle Intervention",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Multi-Domain Lifestyle Intervention","The intervention is a 12-week multi-domain lifestyle program. It targets four behavioral domains: physical activity, nutrition, sleep, and stress regulation. Participants attend twice-weekly supervised online exercise sessions using scalable functional movements performed with bodyweight, resistance bands, and suspension training. The nutrition component provides individualized meal plans based on maintenance calories, emphasizing anti-inflammatory, whole-food nutrition with a macronutrient distribution of approximately 40% carbohydrates, 30% protein, and 30% fat. During the first two weeks, meals are delivered to support adherence. Sleep optimization focuses on circadian-aligned behaviors such as consistent sleep timing and reduced evening light exposure. Stress regulation includes daily breathing exercises, mindfulness practices, and vagal nerve-stimulating techniques. Participants track dadaily behaviors, wellbeing, and wearable data using a billiungual mobile app.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Youssef Idaghdour, Professor","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Natascha Enriquez, MSc","CONTACT","+971501821961","natasha.enriquez@nyu.edu",{"name":22,"role":27,"phone":31,"phoneExt":19,"email":32},"+971561845775","yi3@nyu.edu",[34],{"facility":35,"status":19,"city":36,"state":19,"zip":19,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Yas Clinic","Abu Dhabi","United Arab Emirates","AE",{"type":40,"coordinates":41},"Point",[42,43],54.39696,24.45118,{"lat":43,"lon":42},[46,50,54],{"name":47,"role":27,"phone":48,"phoneExt":19,"email":49},"Lev Brylev, MD, PhD","+971502377993","lev.brylev@adscc.ae",{"name":51,"role":27,"phone":52,"phoneExt":19,"email":53},"Ruqqia Mir, MD","+971553676270","ruqqia.m@adscc.ae",{"name":47,"role":55,"phone":19,"phoneExt":19,"email":19},"SUB_INVESTIGATOR",{"type":57,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100639518","healthy-eating-and-active-living-for-people-living-with-multiple-sclerosis-heal-ms-a-lifestyle-program-for-people-with-multiple-sclerosis-100639518",false,"NCT07589062","Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple Sclerosis","HEAL MS: A Culturally Adapted Lifestyle Medicine Intervention Targeting Metabolic and Immune Dysregulation in Multiple Sclerosis Using Multi-Omics Profiling","HEAL-MS","Inclusion Criteria:\n\n* Confirmed MS diagnosis (McDonald criteria)\n* EDSS score ≤ 6.5 (i.e., ambulatory with or without assistance)\n* Stable disease-modifying therapy for ≥ 3 months\n* Age 18-50\n* Proficiency in English or Arabic\n* Clearance to participate in a structured exercise program\n* Ability to walk, sit and stand independently, and perform light-to-moderate movement patterns, even with modifications\n* Ability and digital literacy to interact with the bilingual HEAL MS mobile app and\n* Access to a computer for participation in online sessions\n\nExclusion Criteria:\n\n* Significant cognitive impairment affecting app use and comprehension of the intervention\n* MS relapse within the past 3 months\n* Pregnancy or planned pregnancy\n* Unmanaged psychiatric disorders\n* Other immune-related or chronic inflammatory or metabolic diseases\n* Concurrent enrollment in another lifestyle intervention","ALL","18 Years","50 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this clinical trial is to learn whether a structured lifestyle program can improve health and wellbeing in people living with multiple sclerosis (MS). The program focuses on four areas: nutrition, physical activity, sleep, and stress management. The study will also examine how lifestyle changes affect biological markers related to inflammation, metabolism, and immune function.\n\nThe main questions the study aims to answer are:\n\nCan a 12-week lifestyle program improve fatigue, physical function, sleep, and quality of life in people with MS? Do lifestyle changes influence biological markers related to inflammation, metabolism, and mitochondrial function?\n\nParticipants will first complete a 12-week observation period to measure their usual lifestyle and health. After this, they will take part in the 12-week HEAL MS lifestyle program.\n\nParticipants will:\n\nAttend four assessment visits at Yas Clinic (baseline, before the intervention, after the intervention, and three months later) Participate in two supervised online exercise sessions per week during the 12-week program Follow a structured nutrition plan, with meals provided during the first two weeks Use a mobile application to log daily habits related to exercise, nutrition, sleep, and stress Complete questionnaires and physical tests and provide blood, saliva, and stool samples during assessment visits\n\nResearchers will analyze these data to understand whether lifestyle interventions can support symptom management and overall health in people living with MS.",[77,78],"Multiple Sclerosis (MS) - Relapsing-remitting","Multiple Sclerosis",[78,80,81,82,83,84,85,86,87,88,89,90,91,92],"Lifestyle Medicine","Exercise Intervention","Lifestyle Intervention","Anti-Inflammatory Diet","Multiomics","Proteomics","Metabolomics","Mitochondrial Dysfunction","Digital Health","Behavioral Change","Fatigue","Neuroinflammation","Lifestyle Diet","NOT_YET_RECRUITING","2026-05-08",{"date":96,"type":97},"2026-05-15","ACTUAL",{"date":99,"type":71},"2026-04-15",{"date":101,"type":71},"2027-11-15",{"name":5,"class":6},1]