[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628220":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":25,"locations":34,"responsibleParty":55,"collaborators":59,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":12,"enrollmentInfo":76,"targetDuration":12,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":92,"overallStatus":37,"whyStopped":12,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"University of California, San Diego","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard of Care","NO_INTERVENTION","Participants in the standard-of-care arm will receive syndromic STI assessment per Botswana national guidelines.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Intervention","EXPERIMENTAL","Participants randomized to the Intervention arm will receive the standard of care with additional Chlamydia trachomatis (CT) and Neisseria gonorrhea (NG) screening and treatment, at two time points: 1) first antenatal care visit and 2) third trimester between 28-32 weeks gestation (n=1,000). If participants are positive for CT and\u002For NG they will receive counseling and treatment according to US CDC guidelines, counseling and information about partner notification and treatment with several options available for partner treatment, and a test of cure after four weeks.",[18],"Diagnostic Test: Chlamydia trachomatis and Neisseria gonorrhoeae screening",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DIAGNOSTIC_TEST","Chlamydia trachomatis and Neisseria gonorrhoeae screening","Screening with Xpert® CT\u002FNG assay at first antenatal care and third trimester",[14],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":12,"email":30},"Adriane Wynn, PhD MPP","CONTACT","+1 (916) 662-1497","awynn@health.ucsd.edu",{"name":32,"role":28,"phone":12,"phoneExt":12,"email":33},"Chelsea Morroni, MBChB, DFSRH, MPH, PhD","cmorroni@ed.ac.uk",[35],{"facility":36,"status":37,"city":38,"state":12,"zip":12,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Botswana Harvard Health Partnership","RECRUITING","Gaborone","Botswana","BW",{"type":42,"coordinates":43},"Point",[44,45],25.90859,-24.65451,{"lat":45,"lon":44},[48,52],{"name":49,"role":28,"phone":50,"phoneExt":12,"email":51},"Bame Bame","‭+267 316 6657‬","bbame@bhp.org.bw",{"name":53,"role":28,"phone":54,"phoneExt":12,"email":12},"Aamirah Mussa, PhD","+26772333222",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Adriane Wynn","Assistant Professor",[60,63],{"name":61,"class":62},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH",{"name":64,"class":6},"Botswana Harvard AIDS Institute Partnership","100628220","healthy-expectancy-through-routine-antenatal-sti-screening-100628220",false,"NCT07458802","Healthy Expectancy Through Routine Antenatal STI Screening","Screening and Treatment for Chlamydia Trachomatis Infection to Prevent Preterm Birth","HERA","Inclusion Criteria:\n\n1. Asymptomatic for cervicovaginitis at first ANC (i.e., not syndromically treated for an STI by clinic midwives at first ANC)\n2. Age ≥ 15 years\n3. Currently pregnant\n4. ≤20 weeks gestation (based on gestational age in obstetric record or last menstrual period if gestational age missing from record)\n5. Attending first ANC visit\n6. Residence in Gaborone, Bostwana or surrounding villages through the time of delivery\n7. Mentally competent to understand study procedures or give informed consent",true,"FEMALE","15 Years",{"count":77,"type":78},2000,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study will evaluate whether routine screening and treatment for two common sexually transmitted infections, chlamydia and gonorrhoea, during pregnancy can reduce preterm birth and other poor birth outcomes in Botswana, and whether this approach is affordable and cost-effective for the health system.\n\nAbout 2,000 pregnant women attending their first antenatal care visit at up to 10 government clinics in Botswana will be invited to join the study. All women will first receive the usual antenatal care services provided in Botswana, including routine health checks and HIV and syphilis testing. Women who enroll in the study will be randomly assigned to one of two groups:\n\n1. Standard of care group: Women receive routine antenatal care only.\n2. Intervention group: In addition to routine antenatal care, women are screened for chlamydia and gonorrhoea using self-collected vaginal swabs at their first antenatal care visit and again in the third trimester.\n\nThe main outcome of the study is whether screening and treating chlamydia and gonorrhoeae reduces preterm birth (before 37 weeks). Other outcomes include low birth weight, very preterm birth, and maternal health conditions.",[84,85,86,87,88,89,90,91],"Antenatal Health","Antenatal Care","STI","Chlamydia Trachomatis Infection in Pregnancy","Chlamydia","Chlamydia Trachomatis","Chlamydia Trachomatis Infection","Preterm Birth",[93,94,95,96,97,98,99,86,100,101,102,39,103,104,105],"antenatal health","antenatal screening","chlamydia","chlamydia trachomatis","chlamydia screening","chlamydia treatment","pregnancy screening","STI screening","STI in pregnancy","preterm delivery","CT infection","chlamydia in pregnancy","birth outcomes","2026-06-30",{"date":108,"type":109},"2026-07-02","ACTUAL",{"date":111,"type":109},"2026-05-25",{"date":113,"type":78},"2030-07-01",{"name":57,"class":6},1]