[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100448079":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":10,"responsibleParty":36,"collaborators":38,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":63,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":10},{"fullName":5,"class":6},"University of East Anglia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HFpEF group",null,"Suspected HFpEF group: 80 patients will be recruited with history of dyspnoea, LV ejection fraction ≥ 50%, raised NTproBNP",[13],"Diagnostic Test: Multi Parametric Cardiac Magnetic Resonance",{"label":15,"type":10,"description":16,"interventionNames":17},"Control group","20 patients with suspected CAD but with no dyspnoea and normal echocardiogram.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Multi Parametric Cardiac Magnetic Resonance","Research based Cardiac MRI evaluation to determine cardiovascular haemodynamics",[15,9],[25],{"name":26,"affiliation":5,"role":27},"Pankaj Garg, MD","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","+441603591721","p.garg@uea.ac.uk",{"name":34,"role":30,"phone":10,"phoneExt":10,"email":35},"Marcus D Flather, MBBS","m.flather@uea.ac.uk",{"type":37,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[39],{"name":40,"class":6},"Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)","100448079","heart-failure-with-preserved-ejection-fraction-evaluation-and-recognition-by-cmr-100448079",false,"NCT05114785","Heart Failure With Preserved Ejection Fraction: Evaluation and Recognition by CMR","PReserved Ejection Fraction Evaluation and Recognition by Cardiac Magnetic Resonance","PREFER-CMR","Inclusion Criteria:\n\n1. Adults: age≥18 years.\n2. Typical HF symptoms (NYHA stage\\>I) within the last six months.\n3. Raised NTproBNP (\\>400 pg\u002Fml)\n4. EF\\>50 % with the absence of structural heart disease on TTE (except left ventricular hypertrophy or left atrial enlargement).\n\nExclusion Criteria:\n\n1. Patients unable\u002Funwilling to provide informed consent.\n2. Bodyweight\\>120 kg or inability to lie flat\u002Fstill.\n3. Contraindication for invasive workup (allergy to contrast, severe renal insufficiency with estimated glomerular filtration rate (eGRF)\\\u003C30 ml\u002Fmin).\n4. Contraindications for a contrast-enhanced CMR study (allergy to contrast, incompatible devices or implants, severe claustrophobia).\n5. Previous medical history of EF \\\u003C50%\n6. Pregnancy\n\nThe extended observational arm of the study will have wider eligibility criteria\n\n\\- Patients undergoing cardiac MRI for clinical indications irrespective of EF","ALL","18 Years",{"count":52,"type":53},100,"ESTIMATED","OBSERVATIONAL","Heart failure with preserved ejection fraction (HFpEF) is a common and growing condition with a poor prognosis but the pathophysiology and management are still being investigated. The PREFER-CMR project aims to evaluate and validate the application of novel 4D cardiac magnetic resonance flow dynamic methods to measure left ventricular pressures and validate these measurements with direct pressure measurement by coronary angiography. This is a prospective observational study of patients with HFpEF undergoing clinical evaluation with coronary angiography who will also undergo contemporaneous cardiac MRI. The primary outcome will be the level of agreement between the two methods using angiography as the reference method.",[57,58],"Heart Failure With Preserved Ejection Fraction","Heart Diseases",[60,61,62],"Heart failure","hemodynamics","magnetic resonance imaging","NOT_YET_RECRUITING","2021-12-13",{"date":66,"type":67},"2022-01-05","ACTUAL",{"date":69,"type":53},"2022-01",{"date":71,"type":53},"2032-01",{"name":5,"class":6}]