[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631554":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":12,"collaborators":10,"id":16,"slug":17,"hasResults":18,"nctId":19,"briefTitle":20,"officialTitle":21,"acronym":10,"eligibilityCriteria":22,"healthyVolunteers":18,"sex":23,"minAge":10,"maxAge":24,"enrollmentInfo":25,"targetDuration":10,"studyType":28,"phases":10,"briefSummary":29,"conditions":30,"keywords":36,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Children with Chronic Liver Disease",null,"This cohort consists of patients under 18 years of age diagnosed with chronic liver disease attending the gastroenterology and hepatology unit at Assiut University Children Hospital. Participants will undergo standard baseline clinical evaluations and investigations to characterize their hepatic and cardiac profiles. These investigations include laboratory tests , abdominal imaging , electrocardiography (ECG) , and echocardiography. Patients with known congenital heart disease or previous cardiac disease are excluded from this cohort.",{"type":13,"investigatorFullName":14,"investigatorTitle":15,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Andrew Gamal Thabet","Resident at Pediatric Department, Assiut University","100631554","heart-problems-in-children-with-chronic-liver-disease-100631554",false,"NCT07502196","Heart Problems in Children With Chronic Liver Disease","Assessment of Cardiac Problems in Children With Chronic Liver Disease","Inclusion Criteria:\n\n* All patients below 18 years who diagnosed with chronic liver disease.\n\nExclusion Criteria:\n\n* All patients known to have congenital heart disease or previous cardiac disease.","ALL","17 Years",{"count":26,"type":27},60,"ESTIMATED","OBSERVATIONAL","Chronic liver disease (CLD) in children can sometimes lead to complications in other parts of the body, including the heart. The primary purpose of this observational study is to assess the presence and type of cardiac problems in children who have been diagnosed with chronic liver disease.\n\nResearchers will observe children under the age of 18 who are receiving care at the gastroenterology and hepatology unit at Assiut University Children Hospital. Participants will undergo standard medical evaluations to check both their liver and heart health.\n\nThese evaluations include:\n\n* A detailed medical history and thorough physical examination\n* Routine blood tests to check liver function, kidney function, coagulation, and electrolytes\n* Abdominal imaging, such as an ultrasound, to look at the liver.\n* An electrocardiogram (ECG) to check the heart's electrical activity and rhythm, including measuring the QTc interval.\n* An echocardiogram to look at the structure of the heart and check how well its chambers and valves are functioning.\n\nThe study aims to identify specific heart conditions that can be associated with severe liver disease, such as portopulmonary hypertension, cirrhotic cardiomyopathy (changes in the heart muscle's function), and electrical repolarization abnormalities. Children who already have known congenital heart disease or a history of other heart problems will not be included in the study.",[31,32,33,34,35],"Chronic Liver Disease (CLD)","Liver Cirrhosis","Cardiac Abnormalities","Portopulmonary Hypertension","Cirrhotic Cardiomyopathy",[37,32,38,34,35,39],"Chronic Liver Disease","Cardiac Problems","Cardiac Repolarization Abnormalities","NOT_YET_RECRUITING","2026-03-25",{"date":43,"type":44},"2026-03-30","ACTUAL",{"date":46,"type":27},"2026-04",{"date":48,"type":27},"2027-05",{"name":5,"class":6}]