[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629309":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":30,"responsibleParty":49,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Istanbul Aydın University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"BPPV Group",null,"Patients diagnosed with benign paroxysmal positional vertigo (BPPV) based on positional testing in the otolaryngology clinic.",[13],"Other: Short-term HRV measurement",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Control Group","Age-, sex-, and body mass index-matched healthy volunteers without a history of vestibular disorders",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Short-term HRV measurement","Short-term heart rate variability (HRV) assessment performed using a non-invasive device that records RR interval variability through hand electrodes. Measurements will be obtained at rest and during controlled breathing to evaluate vagal tone and autonomic nervous system activity.",[9,15],[24],{"name":25,"role":26,"phone":27,"phoneExt":28,"email":29},"Dastan Temirbekov, assistan professor","CONTACT","05314013014","+90","dasekeeee@gmail.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":10,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Medicalpark Florya Hospital","RECRUITING","Istanbul","Küçükçekmece","34295","Turkey (Türkiye)",{"type":39,"coordinates":40},"Point",[41,42],28.94966,41.01384,{"lat":42,"lon":41},[45],{"name":46,"role":26,"phone":47,"phoneExt":28,"email":48},"Nilay Turğut","5387175333","niba.1907@gmail.com",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dastan Temirbekov","Assistan Professor","100629309","heart-rate-variability-in-benign-paroxysmal-positional-vertigo-100629309",false,"NCT07472998","Heart Rate Variability in Benign Paroxysmal Positional Vertigo","Evaluation of Autonomic Function Using Short-Term Heart Rate Variability in Patients With Benign Paroxysmal Positional Vertigo: A Prospective Case-Control Study","BPPV-HRV","Inclusion Criteria:\n\n* BPPV Group\n\nAge 18 years or older\n\nClinical diagnosis of benign paroxysmal positional vertigo (BPPV) confirmed by positional testing (Dix-Hallpike and\u002For Roll test) with positional nystagmus\n\nNo known history of cardiac disease\n\nAbility and willingness to provide written informed consent\n\nHealthy Control Group\n\nAge 18 years or older\n\nNo history of vertigo or known vestibular disorder\n\nAge- and sex-matched to the BPPV group\n\nNo known history of cardiac disease\n\nAbility and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n\nInability to provide informed consent or impaired mental capacity\n\nKnown arrhythmia, heart failure, ischemic heart disease, or other clinically significant cardiac disorder\n\nUse of medications that may directly affect heart rate variability, including beta-blockers, non-dihydropyridine calcium channel blockers, antiarrhythmic drugs, digoxin, systemic corticosteroids, centrally acting sympatholytic agents, or psychotropic medications that may influence autonomic balance\n\nActive infection or systemic inflammatory disease",true,"ALL","18 Years","65 Years",{"count":66,"type":67},104,"ESTIMATED","OBSERVATIONAL","Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder. Although the pathophysiology of BPPV is mainly attributed to the displacement of otoconia within the semicircular canals, recent studies suggest that psychological stress and anxiety may be associated with the onset or recurrence of the disease. However, the biological mechanisms underlying this relationship remain poorly understood, and objective evaluation of autonomic nervous system function in patients with BPPV is limited.\n\nHeart rate variability (HRV) is a non-invasive method widely used to assess autonomic nervous system activity. Short-term HRV measurements provide information about autonomic balance and vagal tone. In particular, parameters such as the root mean square of successive differences (RMSSD) and the coefficient of variation of RR intervals (COV RR\u002FR) are considered indicators of parasympathetic activity.\n\nThe aim of this prospective case-control study is to evaluate vagal tone in patients with BPPV using short-term HRV analysis and to compare the findings with age-, sex-, and body mass index-matched healthy controls. Participants will undergo standardized HRV measurements at rest and during controlled breathing. Perceived stress levels will also be assessed using the Perceived Stress Scale (PSS-10).\n\nThe primary outcomes of the study are RMSSD and the coefficient of variation of RR intervals (COV RR\u002FR), obtained from short-term HRV recordings. These parameters will be compared between BPPV patients and healthy controls, and their associations with perceived stress levels will also be explored. The findings of this study may provide insights into the role of autonomic regulation and stress-related mechanisms in the pathophysiology of BPPV.",[71,72],"BPPV","Stress and Anxiety",[71,74,75,76,77],"stress","HRV","heart rate variability","Benign paroxysmal positional vertigo","2026-04-13",{"date":80,"type":81},"2026-04-16","ACTUAL",{"date":83,"type":81},"2026-04-01",{"date":85,"type":67},"2026-09-01",{"name":5,"class":6},1]