[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519544":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":29,"responsibleParty":106,"collaborators":10,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":110,"sex":115,"minAge":116,"maxAge":10,"enrollmentInfo":117,"targetDuration":10,"studyType":120,"phases":10,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"CMC Ambroise Paré","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Post-cardiac arrest patients",null,[12],"Device: 24-hour Holter monitoring",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DEVICE","24-hour Holter monitoring","Holter monitor is fitted within 2h of ICU admission to acquire a 24-hour electrocardiogram recording",[9],[20,26],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Guillaume GERI, MD, PhD","CONTACT","0146415079","+33","guillaume.geri@clinique-a-pare.fr",{"name":27,"role":22,"phone":10,"phoneExt":10,"email":28},"Cécile NAUDIN, PhD","cecile.naudin@clinique-a-pare.fr",[30,49,64,79,92],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Brest University Hospital","RECRUITING","Brest","Brittany Region","29609","France","FR",{"type":39,"coordinates":40},"Point",[41,42],-4.48628,48.39029,{"lat":42,"lon":41},[45,48],{"name":46,"role":22,"phone":10,"phoneExt":10,"email":47},"Pierre BAILLY, MD","pierre.bailly@chu-brest.fr",{"name":46,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":50,"status":32,"city":51,"state":52,"zip":53,"country":36,"countryCode":37,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Nantes University Hospital","Nantes","Pays de la Loire Region","44093",{"type":39,"coordinates":55},[56,57],-1.55336,47.21725,{"lat":57,"lon":56},[60,63],{"name":61,"role":22,"phone":10,"phoneExt":10,"email":62},"Jean-Baptiste LASCARROU, MD","jeanbaptiste.lascarrou@chu-nantes.fr",{"name":61,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":65,"status":32,"city":66,"state":67,"zip":68,"country":36,"countryCode":37,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Marseille University Hospital","Marseille","Provence-Alpes-Côte d'Azur Region","13005",{"type":39,"coordinates":70},[71,72],5.38107,43.29695,{"lat":72,"lon":71},[75,78],{"name":76,"role":22,"phone":10,"phoneExt":10,"email":77},"Jeremy BOURENNE, MD","jeremy.bourenne@ap-hm.fr",{"name":76,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":80,"status":32,"city":81,"state":82,"zip":83,"country":36,"countryCode":37,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Ambroise Paré - Hartmann Private Hospital Group","Neuilly-sur-Seine","Île-de-France Region","92200",{"type":39,"coordinates":85},[86,87],2.26965,48.8846,{"lat":87,"lon":86},[90,91],{"name":21,"role":22,"phone":10,"phoneExt":10,"email":25},{"name":21,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":93,"status":32,"city":94,"state":82,"zip":95,"country":36,"countryCode":37,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Cochin Hospital","Paris","75014",{"type":39,"coordinates":97},[98,99],2.3488,48.85341,{"lat":99,"lon":98},[102,105],{"name":103,"role":22,"phone":10,"phoneExt":10,"email":104},"Alain CARIOU, MD, PhD","alain.cariou@aphp.fr",{"name":103,"role":22,"phone":10,"phoneExt":10,"email":10},{"type":107,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100519544","heart-rate-variability-in-early-prediction-of-a-noxic-brain-injury-after-cardiac-arrest-100519544",false,"NCT06044922","Heart Rate Variability in Early Prediction of a Noxic Brain Injury After Cardiac Arrest","HEAVENwARd","Inclusion Criteria:\n\n* Admitted in intensive care unit (ICU) after resuscitation from cardiac arrest (in-hospital or out-of-hospital)\n* Coma (Glasgow score \\\u003C 8) after ROSC, requiring sedation and targeted temperature management for at least 24h\n\nExclusion Criteria:\n\n* Dying patient (Limitation of life support techniques at admission to the ICU)\n* Non-Sinus Rhythm\n* Pregnant or breastfeeding women\n* Patient under protection of the adults (guardianship, curators or safeguard of justice)\n* Opposition by the trusted person or by the patient once he\u002Fshe wakes up","ALL","18 Years",{"count":118,"type":119},200,"ESTIMATED","OBSERVATIONAL","Despite advances in post-resuscitation care of patients with cardiac arrest (CA), the majority of survivors who are treated after restoration of spontaneous circulation (ROSC) will have sequelae of hypoxic-ischemic brain injury ranging from mild cognitive impairment to a vegetative state.\n\nEarly prognostication in comatose patients after ROSC remains challenging. Recent recommendations suggest carrying out clinical and paraclinical tests during the first 72 h after ROSC, to predict a poor neurological outcome with a specificity greater than 95% (no pupillary and corneal reflexes, bilaterally absent N20 somatosensory evoked potential wave, status myoclonus, highly malignant electroencephalography including suppressed background ± periodic discharges or burst-suppression, neuron-specific enolase (NSE) \\> 60 µg\u002FL, a diffuse and extensive anoxic injury on brain CT\u002FMRI), but with a low sensitivity due to frequent confounding factors.\n\nThe heart rate variability (HRV) is a simple and non-invasive technique for assessing the autonomic nervous system function. In patients with a recent myocardial infarction, reduced HRV is associated with an increased risk for malignant arrhythmias or death. In neurology, reduced HRV is associated with a poor outcome in severe brain injury patients and allows to predict early neurological deterioration and recurrent ischemic stroke after acute ischemic stroke.\n\nA reduced HRV could be a sensitive, specific and early indicator of diffuse anoxic brain injury after CA.\n\nThis multicenter prospective cohort study assesses the added value of early HRV (within 24h of ICU admission) for neuroprognostication after cardiac arrest.",[123],"Cardiac Arrest",[125,126],"Heart rate variability","Neurologic prognosis","2024-12-11",{"date":129,"type":130},"2024-12-16","ACTUAL",{"date":132,"type":130},"2024-10-23",{"date":134,"type":119},"2027-12-15",{"name":5,"class":6},5]