[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572315":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":27,"responsibleParty":70,"collaborators":72,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":10,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":10,"enrollmentInfo":89,"targetDuration":10,"studyType":92,"phases":10,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"University of Aarhus","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Venous thromboembolism",null,"Patients with acute deep vein thrombosis diagnosed on UL or pulmonary embolism diagnosed on CTA. \\>18 years of age. 120 patients in total.",{"label":13,"type":10,"description":14,"interventionNames":10},"Acute myocardial infarction","With ST segment elevation on ECG and confirmed culprit lesion on coronary angiography. \\>18 years of age. 50 patients in total.",{"label":16,"type":10,"description":17,"interventionNames":10},"Stroke","Stroke confirmed on MRI and diagnosis of atrial fibrillation. \\>18 years of age. 50 patients in total.",{"label":19,"type":10,"description":20,"interventionNames":10},"Healthy participants","No known or prior diseases, no medication. \\>18 years of age. 120 in total.",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Kathrine A Friis, MD, PhD-fellow","CONTACT","+45 20 65 27 32","katfrs@rm.dk",[28,52],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Aarhus University Hospital","RECRUITING","Aarhus","Central Region","8200","Denmark","DK",{"type":37,"coordinates":38},"Point",[39,40],10.21076,56.15674,{"lat":40,"lon":39},[43,47,50],{"name":44,"role":24,"phone":45,"phoneExt":10,"email":46},"Kathrine A Friis, PhD-student","+45 20 86 75 94","kathrinefriis@live.dk",{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Erik L Grove, Assoc. Prof., MD","PRINCIPAL_INVESTIGATOR",{"name":23,"role":51,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"facility":53,"status":30,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Deutsches Herzzentrum de Charité","Berlin","State of Berlin","12203","Germany","DE",{"type":37,"coordinates":60},[61,62],13.41053,52.52437,{"lat":62,"lon":61},[65,69],{"name":66,"role":24,"phone":67,"phoneExt":10,"email":68},"Tobias Petzold, Prof., MD","+49 30- 450- 613745","tobias.petzold@dhzc-charite.de",{"name":66,"role":49,"phone":10,"phoneExt":10,"email":10},{"type":71,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[73,74,77],{"name":29,"class":6},{"name":75,"class":76},"Max Planck Institute of Biochemistry","UNKNOWN",{"name":78,"class":76},"Deutsches Herzzentrum der Charité, Berlin","100572315","heat-shock-protein-47-in-thrombosis-100572315",false,"NCT06731673","Heat Shock Protein 47 in Thrombosis","Heat Shock Protein 47: A Novel Biomarker of Thrombosis Risk","Inclusion Criteria:\n\n* 18 years of age or older\n* Informed consent\n\nVTE group:\n\n* Deep vein thrombosis confirmed on ultrasonography OR\n* Pulmonary embolism confirmed on computed tomography angiography (CTA)\n\nAMI group:\n\n* ST-segment elevation on electrocardiogram (ECG) AND\n* Culprit lesion(s) on coronary angiography\n\nStroke group:\n\n* Stroke confirmed on magnetic resonance imaging AND\n* Atrial fibrillation (Detected on ECG, telemtry or Holter monitoring) AND\n* Stroke localisation classic for AFib: cortical, cerebellar, brainstem or subcortical \\>1.5 cm in diameter\n\nHealthy group:\n\n\\- Healthy\n\nExclusion Criteria:\n\n* \\\u003C18 years of age\n* no informed consent\n* Known haematological disorders\n* Active haematological malignancy\n* Severe renal insufficiency defined as eGFR \\\u003C15 or dialysis\n\nVTE - Pulmonary embolism incidentally detected by CTA conducted for purposes unrelated to pulmonary embolism assessment without concomitant DVT\n\nAMI\n\n* Coronary dissection\n* Takotsubo cardiomyopathy\n\nStroke\n\n\\- Stroke from other causes, e.g. findings pointing towards large vessel disease\n\nHealthy\n\n* Known acute or chronic disease\n* Prior VTE, AMI, stroke or other thromboembolic event",true,"ALL","18 Years",{"count":90,"type":91},340,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial infarction (AMI) or ischaemic stroke compared to healthy volunteers. The main questions it aims to answer are:\n\n1. Are platelet levels of HSP47 higher in patients with acute VTE, AMI or stroke, compared to healthy volunteers.\n2. Does platelet levels of HSP47 remain elevated in patients with acute thrombotic events compared to healthy volunteers at 3 and 12-months of follow-up.\n3. Are platelet levels of HSP47 postively associated with platelet function and negatively associated with fibrinolytic capacity in patients with an acute thrombotic event.\n\nParticipants with VTE, AMI or stroke will be giving a blood sample at diagnosis and again after 3 and 12 months of follow-up. Healthy volunteers will be giving a blood sample once.",[95,96,97],"Venous Thromboembolism (VTE)","Acute Myocardial Infarction With ST Segment Elevation","Stroke (in Patients With Atrial Fibrillation)",[99,100,101,102,103,104,105,16],"HSP47","Heat Shock Protein 47","Biomarker","Novel biomarker","Trombosis","VTE","AMI","2025-08-15",{"date":108,"type":109},"2025-08-21","ACTUAL",{"date":111,"type":109},"2024-12-09",{"date":113,"type":91},"2027-08-31",{"name":5,"class":6},2]