[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100476500":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":26,"centralContacts":39,"locations":49,"responsibleParty":75,"collaborators":26,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":26,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":26,"enrollmentInfo":88,"targetDuration":26,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":52,"whyStopped":26,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Very hot and dry","EXPERIMENTAL","Subjects will be exposed to 3 hours in a climate chamber set to approximately 47 deg C and 15% relative humidity, which reflects a very hot and dry heat wave condition similar to the 2018 Los Angeles heat wave. Four visits will be required to complete this arm, with each visit a different cooling modality applied.",[13,14,15,16],"Other: Water Spray","Other: Fan","Other: Water Spray and Fan","Other: Control",{"label":18,"type":10,"description":19,"interventionNames":20},"Hot and humid","Subjects will be exposed to 3 hours in a climate chamber set to approximately 41 deg C and 40% relative humidity, which reflects hot and humid heat wave similar to the 1995 Chicago heat wave. Four visits will be required to complete this arm, with each visit a different cooling modality applied.",[13,14,15,16],[22,27,31,35],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"Water Spray","Participants will receive water spraying on their body throughout the climate chamber exposure.",[18,9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Fan","Participants will be exposed to a fan throughout the climate chamber exposure.",[18,9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"Water Spray and Fan","Participants will receive both water spraying and a fan throughout the climate chamber exposure.",[18,9],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":26},"Control","Participants will NOT receive either water spray or a fan exposure.",[18,9],[40,45],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},"Rachel Cottle, PhD","CONTACT","214-345-6557","RachelCottle@texashealth.org",{"name":46,"role":42,"phone":47,"phoneExt":26,"email":48},"Erin Harper, BS","214-345-5022","ErinHarper@texashealth.org",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Texas Health Presbyterian Hospital Dallas","RECRUITING","Dallas","Texas","75231","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-96.80667,32.78306,{"lat":62,"lon":61},[65,68,72],{"name":66,"role":42,"phone":43,"phoneExt":26,"email":67},"Zachary McKenna, PhD","ZacharyMckenna@texashealth.org",{"name":69,"role":42,"phone":70,"phoneExt":26,"email":71},"Taysom Wallace, MS","214.345.5022","TaysomWallace@texashealth.org",{"name":73,"role":74,"phone":26,"phoneExt":26,"email":26},"Craig Crandall, PhD","PRINCIPAL_INVESTIGATOR",{"type":74,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Craig Crandall","Professor of Internal Medicine","100476500","heat-waves-and-the-elderly---cooling-modalities-100476500",false,"NCT05484739","Heat Waves and the Elderly - Cooling Modalities","Heat Waves in the Elderly: Reducing Thermal and Cardiovascular Consequences","Inclusion Criteria:\n\n* 65 years of age or older\n* Free of any significant underlying medical problems based upon a detailed medical history and physical exam\n\nExclusion Criteria:\n\n* Known heart disease\n* Other chronic medical conditions requiring regular medical therapy including cancer, diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia etc;\n* Abnormality detected on routine screening suggestive of provokable ischemia or previously undetected cardiac disease or resting left bundle branch block on screening electrocardiogram.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years\n* Subject with a body mass index ≥31 kg\u002Fm2\n* Pregnant individuals",true,"ALL","65 Years",{"count":89,"type":90},100,"ESTIMATED","INTERVENTIONAL",[93],"NA","The purpose of this study is to assess how well cooling modalities work in reducing cardiovascular stress of the elderly to heat wave conditions",[96,97],"Aging","Hyperthermia",[99,100,101,102],"aging","heat wave","cardiovascular","low-energy cooling","2025-10-21",{"date":105,"type":106},"2025-10-23","ACTUAL",{"date":108,"type":106},"2023-02-21",{"date":110,"type":90},"2026-08-31",{"name":5,"class":6},1]