[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625626":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":57,"collaborators":12,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":12,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":39,"whyStopped":12,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Columbia University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"No photobiomodulation","NO_INTERVENTION","Participants will receive the same treatment (IVF\u002FICSI cycles with PGT-A). Participant's resultant oocytes will be randomized to not receive PBM.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Photobiomodulation","EXPERIMENTAL","Participants will receive the same treatment (IVF\u002FICSI cycles with PGT-A). Participant's resultant oocytes will be randomized to receive PBM.",[18],"Other: Photobiomodulation",[20],{"type":6,"name":14,"description":21,"armGroupLabels":22,"otherNames":12},"Photobiomodulation (PBM): also known as low-level light therapy (LLLT), involves the application of low-intensity red or near-infrared (NIR) light to modulate mitochondrial activity.",[14],[24],{"name":25,"affiliation":5,"role":26},"Samuel Zev Williams, MD\u002FPhD","PRINCIPAL_INVESTIGATOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":12,"email":32},"Samuel Zev Williams, MD, PhD","CONTACT","646-756-8282","zw2421@cumc.columbia.edu",{"name":34,"role":30,"phone":31,"phoneExt":12,"email":35},"Laura C Gemmell, MD, MSc","lg3094@cumc.columbia.edu",[37],{"facility":38,"status":39,"city":40,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Columbia University Fertility Center","RECRUITING","New York","10019","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-74.00597,40.71427,{"lat":48,"lon":47},[51,52,55],{"name":34,"role":30,"phone":31,"phoneExt":12,"email":35},{"name":53,"role":30,"phone":31,"phoneExt":12,"email":54},"Stephanie Morgan, MS","sm3415@cumc.columbia.edu",{"name":56,"role":26,"phone":12,"phoneExt":12,"email":12},"Samuel Z Gemmell, MD, PhD",{"type":26,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Samuel Zev Williams","Director of Columbia University Fertility Center; Wendy D. Havens Associate Professor of Women's Health; Chief of the Division of Reproductive Endocrinology and Infertility at Columbia University Irving Medical Center","100625626","helios-advanced-human-oocyte-illumination-to-enhance-development-100625626",false,"NCT07425080","HELIOS Advanced: Human Oocyte Illumination to Enhance Development","HELIOS-Advanced: A Prospective, Staged Dose-Escalation Study of Photobiomodulation to Improve Embryo Development in In Vitro Fertilization","HELIOS-A","Inclusion Criteria:\n\n* Female age between 18-48 years at the time of the IVF\u002FICSI cycle\n* Undergoing blastocyst culture\n* Using own oocytes\n* Has at least two oocytes available for randomization\n* Consenting to oocyte level randomization\n* Plan to transfer euploid embryo within 6 months\n\nExclusion Criteria:\n\n* Use of donor oocytes or gestational carrier\n* Concurrent experimental laboratory inventions outside of protocol\n* Refusal of randomization or request for non-standard handling",true,"FEMALE","18 Years","48 Years",{"count":73,"type":74},270,"ESTIMATED","INTERVENTIONAL",[77],"NA","Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the \"power plants\" of the cells (called mitochondria) don't work as well. This makes it harder for eggs and embryos to develop normally. One possible way to help is with a gentle light treatment called photobiomodulation (PBM). This uses a special type of red light that boosts energy production in cells and helps them stay healthy. This study will test whether adding this light treatment during in vitro fertilization (IVF) can improve embryo growth and pregnancy outcomes.",[80],"IVF Outcomes",[82,83,84],"Infertility","Embryo arrest","Fertility","2026-03-23",{"date":87,"type":88},"2026-03-25","ACTUAL",{"date":90,"type":74},"2026-03-24",{"date":92,"type":74},"2028-06-01",{"name":5,"class":6},1]