[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612247":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":41,"responsibleParty":58,"collaborators":34,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":34,"maxAge":71,"enrollmentInfo":72,"targetDuration":34,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":93,"whyStopped":34,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Ilsan Cha hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group_R","EXPERIMENTAL","TIVA with remimazolam plus remifentanil",[13],"Drug: Remimazolam",{"label":15,"type":16,"description":17,"interventionNames":18},"Group_P","ACTIVE_COMPARATOR","TIVA with propofol plus remifentanil",[19],"Drug: Propofol",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Remimazolam","Induction with remimazolam 6 mg·kg-¹·h-¹ with remifentanil Ce 4 ng·mL-¹ (Minto model); maintenance remimazolam 1-2 mg·kg-¹·h-¹, titrated (±0.2) to maintain PSI 25-50 and hemodynamic targets. Standard care otherwise per protocol.",[9],[27],"Byfavo",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Propofol","Induction with propofol Ce 4 ng·mL-¹ with remifentanil Ce 4 ng·mL-¹; maintenance propofol Ce 2.5-3.5 ng·mL-¹, titrated (±0.2) to maintain PSI 25-50 and hemodynamic targets. Standard care otherwise per protocol.",[15],[33],"Fresofol MCT 2%",null,[36],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Joohyun Lee Assistant Professor, Dept. of Anesthesiology and Pain Medicine, MD","CONTACT","+82-31-782-8415","hightothesky1004@gmail.com",[42,54],{"facility":43,"status":34,"city":44,"state":45,"zip":46,"country":47,"countryCode":34,"cosmosGeoPoint":48,"geoPoint":53,"contacts":34},"CHA Ilsan Medical Center","Goyang-si","Gyeonggi-do","10414","South Korea",{"type":49,"coordinates":50},"Point",[51,52],126.835,37.65639,{"lat":52,"lon":51},{"facility":43,"status":34,"city":44,"state":34,"zip":34,"country":47,"countryCode":34,"cosmosGeoPoint":55,"geoPoint":57,"contacts":34},{"type":49,"coordinates":56},[51,52],{"lat":52,"lon":51},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Joohyun Lee","Assistant Professor, Department of Anesthesiology and Pain Medicine, CHA University","100612247","hemodynamic-effects-of-remimazolam-vs-propofol-during-robot-assisted-gynecologic-surgery-100612247",false,"NCT07251101","Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery","A Randomized, Parallel, Open-label With Blinded Assessment Study Comparing Hemodynamic Profiles Between Remimazolam- and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Robot-assisted Gynecologic Surgery","By_HD","Inclusion Criteria:\n\n* Female patients \\\u003C65 years of age\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled to undergo robotic hysterectomy under general anesthesia\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\> 35 kg\u002Fm²\n* Baseline hypotension (systolic blood pressure \\\u003C100 mmHg) or bradycardia (heart rate \\\u003C60 bpm)\n* History of ischemic heart disease or cardiac conduction block\n* Significant cardiopulmonary disease, including hypoxemia (SpO₂ \\\u003C90%), uncontrolled asthma, or chronic obstructive pulmonary disease (COPD)\n* Use of inhalational anesthetics during anesthesia\n* Conversion from robotic\u002Flaparoscopic surgery to open laparotomy","FEMALE","65 Years",{"count":73,"type":74},58,"ESTIMATED","INTERVENTIONAL",[77],"NA","This single-center study at CHA Ilsan Medical Center compares intraoperative hemodynamics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery requiring pneumoperitoneum and steep Trendelenburg positioning.",[80,81,82],"Anesthesia, Intravenous","Hemodynamic Stability","Gynecologic Surgery",[84,85,86,87,88,89,90,91,92],"remimazolam","propofol","hemodynamics","laparoscopic surgery","general anesthesia","Trendelenburg position","pneumoperitoneum","gynecologic surgery","total intravenous anesthesia (TIVA)","NOT_YET_RECRUITING","2026-03-23",{"date":96,"type":97},"2026-03-27","ACTUAL",{"date":99,"type":74},"2026-05-02",{"date":101,"type":74},"2027-12-30",{"name":5,"class":6},2]