[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644254":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":30,"responsibleParty":94,"collaborators":25,"id":96,"slug":97,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":98,"sex":103,"minAge":104,"maxAge":25,"enrollmentInfo":105,"targetDuration":25,"studyType":108,"phases":109,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":116,"whyStopped":25,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"University Hospital, Limoges","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"T-piece SBT then PS-ZEEP SBT","EXPERIMENTAL","In this arm, T-piece SBT will be evaluated first and PS-ZEEP SBT in a second time.",[13],"Procedure: T-piece SBT",{"label":15,"type":10,"description":16,"interventionNames":17},"PS-ZEEP SBT then T-piece SBT","In this arm, PS-ZEEP SBT will be evaluated first and T-piece SBT ina second time.",[18],"Procedure: PS-ZEEP SBT",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","T-piece SBT","T-piece SBT will be evaluated first and PS-ZEEP SBT in a second time. If the first SBT fails, regardless of the modality used or the cause of failure, the second SBT will not be performed. The patient will then be managed according to the participating centers' standard of care (treatment guided by the main mechanism of WIPE identified by echocardiography). The two SBTs will be separated by at least 6 hours, during which no therapeutic changes will be made (in case of success at the first SBT). This interval corresponds to the usual SBT schedule (typically one SBT in the morning and one in the afternoon).",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"PS-ZEEP SBT","In this arm, PS-ZEEP SBT will be evaluated first and T-piece SBT ina second time. If the first SBT fails, regardless of the modality used or the cause of failure, the second SBT will not be performed. The patient will then be managed according to the participating centers' standard of care (treatment guided by the main mechanism of WIPE identified by echocardiography). The two SBTs will be separated by at least 6 hours, during which no therapeutic changes will be made (in case of success at the first SBT). This interval corresponds to the usual SBT schedule (typically one SBT in the morning and one in the afternoon).",[15],[31,51,67,82],{"facility":32,"status":25,"city":33,"state":25,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Ambroise Paré Hospital -APHP","Boulogne-Billancourt","92100","France","FR",{"type":38,"coordinates":39},"Point",[40,41],2.24128,48.83545,{"lat":41,"lon":40},[44,49],{"name":45,"role":46,"phone":47,"phoneExt":25,"email":48},"Adrien JOSEPH, MD","CONTACT","0149095601","adrien.joseph@aphp.fr",{"name":45,"role":50,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"facility":52,"status":25,"city":53,"state":25,"zip":54,"country":35,"countryCode":36,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Limoges University hospital","Limoges","87042",{"type":38,"coordinates":56},[57,58],1.24759,45.83362,{"lat":58,"lon":57},[61,66],{"name":62,"role":46,"phone":63,"phoneExt":64,"email":65},"Philippe VIGNON, MD","05 55 05 88 41","+33","philippe.vignon@chu-limoges.fr",{"name":62,"role":50,"phone":25,"phoneExt":25,"email":25},{"facility":68,"status":25,"city":69,"state":25,"zip":70,"country":35,"countryCode":36,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Nice University Hospital - Archet","Nice","06000",{"type":38,"coordinates":72},[73,74],7.26608,43.70313,{"lat":74,"lon":73},[77,81],{"name":78,"role":46,"phone":79,"phoneExt":64,"email":80},"Mathieu JOZWIAK, MD","0492035510","jozwiak.m@chu-nice.fr",{"name":78,"role":50,"phone":25,"phoneExt":25,"email":25},{"facility":83,"status":25,"city":69,"state":25,"zip":70,"country":35,"countryCode":36,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Nice university hospital - Pasteur",{"type":38,"coordinates":85},[73,74],{"lat":74,"lon":73},[88,92],{"name":89,"role":46,"phone":90,"phoneExt":25,"email":91},"denis DOYEN, MD+33","0492033622","denis.doyen@chu-nice.fr",{"name":93,"role":50,"phone":25,"phoneExt":25,"email":25},"Denis DOYEN, MD",{"type":95,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100644254","hemodynamic-impact-of-the-spontaneous-ventilation-test-in-patients-at-risk-of-weaning-pulmonary-oedema-100644254",false,"NCT07666880","Hemodynamic Impact of the Spontaneous Ventilation Test in Patients at Risk of Weaning Pulmonary Oedema","WAPITI 2","Inclusion Criteria:\n\n* Adult patient (\\> 18 years) on invasive mechanical ventilation in the ICU for more than 48 hours\n* In the ventilator weaning phase with a first SBT planned\n* At risk of WIPE: age over 65 years and\u002For any type of heart disease and\u002For chronic respiratory failure and\u002For obesity\n\nExclusion Criteria:\n\n* Patient who has already participated in the study\n* No transthoracic echocardiographic images suitable for analysis\n* Non-sinus rhythm (including pacemaker)\n* Tracheostomy\n* Chronic neuromuscular or neurodegenerative disease\n* Persons deprived of liberty or under legal protection\n* Pregnant or breastfeeding woman","ALL","18 Years",{"count":106,"type":107},88,"ESTIMATED","INTERVENTIONAL",[110],"NA","Weaning-induced pulmonary edema (WIPE) from the ventilator is a frequent cause of extubation failure or delay, which prolongs the duration of invasive mechanical ventilation and the associated morbidity and mortality. WIPE is a very frequent cause of extubation failure in at-risk patients. A spontaneous breathing trial (SBT) is performed before extubating a patient, either by disconnecting the patient from the ventilator (T-piece SBT) or by setting the ventilator to spontaneous breathing mode with pressure support at 7 cm H2O and zero positive end-expiratory pressure (PS-ZEEP SBT). There is currently no recommendation regarding which SBT modality should be used, particularly in patients at risk of WIPE. The hemodynamic changes induced by the SBT can lead to WIPE, which typically develops within minutes of the SBT onset.\n\nThe hypothesis being tested is that, by altering intrathoracic pressure during the patient's inspiration (negative pressure), the T-piece SBT leads to a greater increase in left ventricular filling pressures compared to the PS-ZEEP SBT.",[113],"Weaning-induced Pulmonary Edema",[115],"Weaning-induced pulmonary edema","NOT_YET_RECRUITING","2026-06-18",{"date":119,"type":120},"2026-06-24","ACTUAL",{"date":122,"type":107},"2026-08-01",{"date":124,"type":107},"2029-08-07",{"name":5,"class":6},4]