[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557293":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":47,"collaborators":20,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":20,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Lithuanian University of Health Sciences","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Passive leg raising and Remote ischemic conditioning","EXPERIMENTAL","Supine position was followed by the passive leg raising (PLR) maneuver. After completing the PLR test, participants were placed in the supine position for 5 min. Thereafter, remote ischemic conditioning (RIC) was performed. After the RIC procedure, the patient is left in supine position for 5 minutes. Then the PLR test was repeated, after which the participants were placed in a supine position for another 5 min at rest. When the patient fluid responder, physician in charge may decide to perform a fluid infusion (500 mL of crystaloids). The PLR test can also be performed to make decision for fluid removal. This decision is triggered by a negative PLR test in the later phase of ICU treatment. If the physician has decided to administer a fluids, systemic hemodynamics and peripheral perfusion index are measured immediately after completion of the fluid infusion.",[13],"Procedure: Remote ischemic conditioning",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Remote ischemic conditioning","Remote ischemic conditioning (RIC) procedure comprise three repetitions of brachial cuff inflation to 200 mmHg for five minutes following deflation to 0 mmHg for another five minutes. The procedure overall took 30 minutes.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Andrius Pranskunas, PhD, prof.","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","+37037326425","andrius.pranskunas@lsmu.lt",[31],{"facility":32,"status":33,"city":34,"state":20,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"The Hospital of Lithuanian University of Health Sciences Kauno klinikos, department of Intensive care","RECRUITING","Kaunas","50161","Lithuania","LT",{"type":39,"coordinates":40},"Point",[41,42],23.90909,54.90156,{"lat":42,"lon":41},[45,46],{"name":23,"role":27,"phone":20,"phoneExt":20,"email":20},{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Andrius Pranskunas","prof.","100557293","hemodynamic-variations-during-remote-ischemic-conditioning-in-critical-ill-patients-100557293",false,"NCT06536231","Hemodynamic Variations During Remote Ischemic Conditioning in Critical Ill Patients","HERICA","Inclusion Criteria:\n\n* aged over 18 years,\n* admitted to the intensive care unit,\n* monitored with a transpulmonary thermodilution device with calibrated pulse contour analysis (Pulsion Medical Systems, Munich, Germany),\n* decision by the physician in charge to perform passive leg raising.\n\nExclusion Criteria:\n\n* pregnancy,\n* advanced malignancy,\n* peripheral artery disease affecting both arms,\n* head trauma,\n* deep vein thrombosis in the lower limbs,\n* intra-abdominal hypertension, defined as an intra-abdominal pressure greater than 12 mmHg.","ALL","18 Years","85 Years",{"count":61,"type":62},50,"ESTIMATED","INTERVENTIONAL",[65],"NA","The main objectives of this study are to evaluate the changes in hemodynamics occurring during the remote ischemic conditioning (RIC) procedure and to compare the hemodynamic responses elicited by passive leg raising before and after the RIC intervention.",[68],"Critical Illness",[17,70,71,72,73],"Passive leg raising","Hemodynamic","Perfusion index","Fluid responsiveness","2024-08-10",{"date":76,"type":77},"2024-08-13","ACTUAL",{"date":79,"type":77},"2024-01-01",{"date":81,"type":62},"2025-03-31",{"name":5,"class":6},1]