[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100488595":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":32,"responsibleParty":47,"collaborators":24,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":24,"enrollmentInfo":58,"targetDuration":24,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Medical University of Graz","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequential HD - Conventional HD","ACTIVE_COMPARATOR","In sequence A patients will be treated with sequential HD first, for a total of 8 session and then switched to a conventional HD schedule for another 8 sessions.",[13],"Procedure: isolated Ultrafiltration (iso-UF)",{"label":15,"type":10,"description":16,"interventionNames":17},"Conventional HD - Sequential HD","In sequence A patients will be treated with conventional HD first, for a total of 8 session and then switched to a sequential HD schedule for another 8 sessions.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","isolated Ultrafiltration (iso-UF)","isolated Ultrafiltration",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Alexander H Kirsch","CONTACT","+43316385","16023","alexander.kirsch@medunigraz.at",[33],{"facility":5,"status":34,"city":35,"state":24,"zip":24,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Graz","Austria","AT",{"type":39,"coordinates":40},"Point",[41,42],15.44197,47.06733,{"lat":42,"lon":41},[45],{"name":46,"role":28,"phone":29,"phoneExt":30,"email":31},"Alexander Kirsch, MD",{"type":48,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100488595","hemodynamics-in-chronic-hemodialysis-patients-undergoing-isolated-ultrafiltration-compared-to-conventional-hemodialysis-100488595",false,"NCT05642156","Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis","ISO-UF","Inclusion Criteria:\n\n* Written consent of the participant after being informed\n* At least 18 years of age\n* End stage kidney disease patient undergoing hemodialysis\n* Dry weight stable for a minimum of one month\n* Interdialytic weight gain of \\>2 liters in the short interdialytic interval\n\nExclusion Criteria:\n\n* No informed consent was obtained\n* Patients with a pacemaker or implanted medical device that prevents compliance with study regulations\n* Patients treated with hemodiafiltration\n* Patients treated with medium cut-off membranes (Theranova, Baxter)\n* Patients with recurrent severe hyperkalemia after the short interdialytic interval (K+ concentration \\> 6.0 mmol\u002FL, requiring more than 2 hours of dialysis to ameliorate the post-dialytic shift from other compartments.\n* Women of childbearing age not using contraception","ALL","18 Years",{"count":59,"type":60},32,"ESTIMATED","INTERVENTIONAL",[63],"NA","Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.",[66],"End Stage Kidney Disease",[68,69],"hemodialysis","ultrafiltration","2025-03-03",{"date":72,"type":73},"2025-03-04","ACTUAL",{"date":75,"type":73},"2022-11-02",{"date":77,"type":60},"2025-12-31",{"name":5,"class":6},1]