[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571298":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":41,"responsibleParty":60,"collaborators":25,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":25,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Ottawa Hospital Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Restrictive transfusion strategy","EXPERIMENTAL","The restrictive transfusion strategy will consist of administering red blood cell transfusion when the participant's hemoglobin level is measured below 70 g\u002FL or to maintain a hemoglobin target range of 70-80 g\u002FL.",[13],"Procedure: Restrictive Transfusion",{"label":15,"type":10,"description":16,"interventionNames":17},"Liberal transfusion strategy","The liberal transfusion strategy will consist of administering red blood cell transfusion when the participant's hemoglobin level is measured below 90 g\u002FL or to maintain a hemoglobin target range of 90-100 g\u002FL.",[18],"Procedure: Liberal transfusion",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Restrictive Transfusion","Red blood cell transfusion when the participant's hemoglobin level is measured below 70 g\u002FL or to maintain a hemoglobin target range of 70-80 g\u002FL. This strategy will be adhered to during surgery and up to 6 hours in the post-operative anesthesia care unit.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Liberal transfusion","Red blood cell transfusion when the participant's hemoglobin level is measured below 90 g\u002FL or to maintain a hemoglobin target range of 90-100 g\u002FL. This strategy will be adhered to during surgery and up to 6 hours in the post-operative anesthesia care unit.",[15],[31],{"name":32,"affiliation":5,"role":33},"Guillaume Martel, MD, MSc, FRCSC, FACS","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Zanna Vanterpool, MSc","CONTACT","6137378899","71484","zvanterpool@ohri.ca",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"The Ottawa Hospital","RECRUITING","Ottawa","Ontario","K1H 8L6","Canada","CA",{"type":51,"coordinates":52},"Point",[53,54],-75.69812,45.41117,{"lat":54,"lon":53},[57],{"name":32,"role":37,"phone":38,"phoneExt":58,"email":59},"71053","gumartel@toh.ca",{"type":61,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100571298","hemoglobin-levels-for-blood-transfusions-during-and-after-surgery-100571298",false,"NCT06718439","Hemoglobin Levels for Blood Transfusions During and After Surgery","Threshold for Operative and Postoperative Hemoglobin Trigger for Red Blood Cell Transfusion: A Pilot Randomized Controlled Trial (TOPGUN-Pilot)","TOPGUN-Pilot","Inclusion Criteria:\n\n* Adult patients, age ≥18.\n* Elective or urgent surgery.\n* Risk of red blood cell transfusion of at least 10 percent.\n* Preoperative hemoglobin of less than 130 g\u002FL.\n* Intraoperative hemoglobin of ≤ 100 g\u002FL at any time during surgery.\n\nExclusion Criteria:\n\n* Active major hemorrhage as indication for surgery (e.g. ruptured aneurysm, polytrauma, etc.).\n* Acute coronary syndrome or myocardial infarction within the past 6 weeks.\n* Cardiac surgery.\n* Liver transplantation.\n* Surgery for moderate to severe (Glasgow Coma Scale (GCS) score ≤ 12) traumatic brain injury.\n* Pregnancy or obstetrical surgery.\n* Patient refusal of blood products.\n* Inability to provide consent.","ALL","18 Years",{"count":73,"type":74},384,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this pilot clinical trial is to learn if it is achievable to conduct a large-scale clinical trial whereby, the investigators will compare two ways of deciding when to give a blood transfusion during surgery. Participants in this study are adults undergoing surgery with a risk of significant blood loss.\n\nThe main question it aims to answer is:\n\n* Is a trial designed to definitively test and compare two different red blood cell transfusion strategies feasible?\n\nParticipants will:\n\n* Receive blood transfusions during surgery based on a higher (less than 90 g\u002FL) or a lower (less than 70 g\u002FL) hemoglobin value.\n* Complete questionnaires at 30 and 90 days after surgery.",[80,81],"Blood Transfusion","Surgery",[83,84,85,86,87,88],"Red blood cell transfusion","hemoglobin threshold","blood loss management","liberal transfusion practice","restrictive transfusion practice","intraoperative","2025-07-29",{"date":91,"type":92},"2025-07-31","ACTUAL",{"date":94,"type":92},"2025-04-16",{"date":96,"type":74},"2027-01-15",{"name":5,"class":6},1]