[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100494443":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":38,"locations":46,"responsibleParty":63,"collaborators":66,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Southern California","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"HEPA first and sham","EXPERIMENTAL","This group of participants will be assigned an intervention of HEPA filters with the capacity to reduce PM2.5 levels at their residence for 6 months. After 6-month wash-out period, will be assigned to sham filters for 6 months.",[13,14],"Device: HEPA filter","Device: Sham filter",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham first and HEPA","SHAM_COMPARATOR","This group of participants will be assigned an intervention of sham filters without the capacity to reduce PM2.5 levels at their residence for 6 months. After 6-month wash-out period, will be assigned to HEPA filters for 6 months.",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","HEPA filter","HEPA filters with the capacity to reduce PM2.5 levels",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham filter","sham filters without the capacity to reduce PM2.5 levels",[9,16],[32,35],{"name":33,"affiliation":5,"role":34},"Zhanghua Chen, PhD","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":37,"role":34},"Junfeng Zhang, PhD","Duke University",[39,43],{"name":33,"role":40,"phone":41,"phoneExt":26,"email":42},"CONTACT","323-442-2109","zhanghuc@usc.edu",{"name":36,"role":40,"phone":44,"phoneExt":26,"email":45},"919-681-7782","junfeng.zhang@duke.edu",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Keck School of Medicine, University of Southern California","RECRUITING","Los Angeles","California","90033","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-118.24368,34.05223,{"lat":59,"lon":58},[62],{"name":33,"role":40,"phone":41,"phoneExt":26,"email":42},{"type":34,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Zhanghua Chen","Assistant Professor",[67],{"name":37,"class":6},"100494443","hepa-pm25-and-cardiometabolic-health-100494443",false,"NCT05718245","HEPA, PM2.5, and Cardiometabolic Health","Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals","Inclusion Criteria:\n\n* Age between 65 and 84 years old;\n* Nonsmoker for at least 1 year;\n* History of BMI ≥ 25 kg\u002Fm2 in the past based on EMR information;\n* Either an English or Spanish speaker;\n* Live in the Los Angeles County.\n\nExclusion Criteria:\n\n* History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);\n* Currently have active cancer treatment;\n* The residential house has already had HEPA filters;\n* Participants will move out of the current house in the next 2 years;\n* Participants will spend more than one month living outside the primary home;\n* Have any health conditions that prohibit collecting health and covariate data and biospecimen;\n* The residential houses are not feasible for setting up air purifiers and air pollutants monitors;\n* Have high blood glucose from finger stick test (\\> 200 mg\u002FdL).",true,"ALL","65 Years","84 Years",{"count":80,"type":81},52,"ESTIMATED","INTERVENTIONAL",[84],"NA","The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.",[87,88],"Air Pollution","Cardiometabolic Health",[90,91,92,23,93],"Air pollution","Particulate matter","Air purifier","Cardiometabolic health","2025-07-29",{"date":96,"type":97},"2025-08-01","ACTUAL",{"date":99,"type":97},"2023-03-15",{"date":101,"type":81},"2026-12-31",{"name":5,"class":6},1]