[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555449":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":35,"locations":44,"responsibleParty":57,"collaborators":24,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":24,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":24,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":86,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Aga Khan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"LMW Heparin 5000 U\u002FML-Aspirin 75 MG","ACTIVE_COMPARATOR","Patients will receive 5000 unit of low molecular weight heparin subcutaneously once daily along with tablet aspirin 75 MG once daily, for additional thromboprophylaxis for free flap. The flaps of these patients will be monitored as standard clinical examination and outcome will be recorded until 4th post operative day.",[13],"Drug: LMW Heparin 5000 U\u002FML-Aspirin 75 MG",{"label":15,"type":10,"description":16,"interventionNames":17},"LMW Heparin 5000 U\u002FML","Patients will receive 5000 unit of low molecular weight heparin subcutaneously once daily according to institutional protocol as routine practice for prevention of deep venous thrombosis in post operative period. The flaps of these patients will be monitored as standard clinical examination and outcome will be recorded until 4th post operative day.",[18],"Drug: LMW Heparin 5000 U\u002FML",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Arm 1",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Arm 2",[15],[29,32],{"name":30,"affiliation":5,"role":31},"Fizzah Arif, MD","PRINCIPAL_INVESTIGATOR",{"name":33,"affiliation":5,"role":34},"Fazlur Rahman, MD","STUDY_DIRECTOR",[36,40],{"name":30,"role":37,"phone":38,"phoneExt":24,"email":39},"CONTACT","+92 336 2230665","fizzah.arif@aku.edu",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},"Ceemal Khan, BS","+ 92 333 1334859","ceemal.khan@aku.edu",[45],{"facility":5,"status":24,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":24},"Karachi","Sindh","72000","Pakistan","PK",{"type":52,"coordinates":53},"Point",[54,55],67.0104,24.8608,{"lat":55,"lon":54},{"type":31,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Ceemal Khan","Research Associate","100555449","heparin-alone-vs-heparin-aspirin-combo-in-free-flap-survival-100555449",false,"NCT06512233","Heparin Alone vs. Heparin-Aspirin Combo in Free Flap Survival","Dual Therapy Dilemma: Heparin Alone vs. Heparin-Aspirin Combo in Free Flap Survival","Inclusion Criteria:\n\n* Patients undergoing free flap surgery\n* Age between 18 and 70 years\n\nExclusion Criteria:\n\n* Known hypersensitivity to heparin or aspirin\n* History of bleeding disorders\n* Concurrent use of other anticoagulant or antiplatelet medications\n* Severe renal or hepatic impairment\n* Preoperative use of aspirin that could not be stopped five days before surgery due to a higher risk of cardiac-related complications.",true,"ALL","18 Years","70 Years",{"count":72,"type":73},126,"ESTIMATED","INTERVENTIONAL",[76],"NA","This randomized clinical trial aims to compare the effectiveness of heparin alone versus combination therapy of Heparin- Aspirin in improving free flap survival in patients undergoing reconstructive surgery. Participants will be randomly assigned to receive either heparin or a combination therapy, and the primary outcome measure will be the survival rate of the free flap at various time points post-surgery",[79],"Complication,Postoperative",[81,82,83,84,85],"Ischemia","Thrombosis","Vascular Complications","Surgical Wound Healing","Reconstructive Surgery Complications","NOT_YET_RECRUITING","2024-07-19",{"date":89,"type":90},"2024-07-23","ACTUAL",{"date":92,"type":73},"2025-01",{"date":94,"type":73},"2025-12",{"name":5,"class":6},1]