[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100432223":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":18,"responsibleParty":54,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":7,"eligibilityCriteria":65,"healthyVolunteers":62,"sex":66,"minAge":7,"maxAge":7,"enrollmentInfo":67,"targetDuration":7,"studyType":70,"phases":7,"briefSummary":71,"conditions":72,"keywords":83,"overallStatus":41,"whyStopped":7,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Baylor College of Medicine","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Lindsay Burrage, MD, PhD","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Saima Ali, MSN","CONTACT","832-822-4183","saima.ali@bcm.edu",[19,40],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Children's National Medical Center","NOT_YET_RECRUITING","Washington D.C.","District of Columbia","20010","United States","US",{"type":28,"coordinates":29},"Point",[30,31],-77.03637,38.89511,{"lat":31,"lon":30},[34,38],{"name":35,"role":15,"phone":36,"phoneExt":7,"email":37},"Kara Simpson, MS, CGC","202-476-6216","ksimpson@childrensnational.org",{"name":39,"role":11,"phone":7,"phoneExt":7,"email":7},"Nicholas A Mew, MD",{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":25,"countryCode":26,"cosmosGeoPoint":45,"geoPoint":49,"contacts":50},"RECRUITING","Houston","Texas","77030",{"type":28,"coordinates":46},[47,48],-95.36327,29.76328,{"lat":48,"lon":47},[51,53],{"name":52,"role":15,"phone":16,"phoneExt":7,"email":17},"Saima Ali",{"name":10,"role":11,"phone":7,"phoneExt":7,"email":7},{"type":11,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Lindsay Burrage","Principal Investigator",[58],{"name":59,"class":6},"Children's National Research Institute","100432223","hepatic-histopathology-in-urea-cycle-disorders-100432223",false,"NCT04908319","Hepatic Histopathology in Urea Cycle Disorders","Inclusion Criteria:\n\n* Diagnosis of primary urea cycle disorder based on clinical suspicion confirmed by enzyme activity, DNA testing or metabolite analysis.\n* History of liver transplantation and\u002For liver biopsy OR\n* Planned liver transplantation and\u002For liver biopsy\n\nExclusion Criteria:\n\n* Unavailability of histopathology report from the liver biopsy or explant, or unavailability of liver tissue or slides from the biopsy or explant OR\n* Anticipated inability to obtain pathology report, liver disease, tissue blocks, or pathology slides after liver biopsy or transplantation\n* Known history of a secondary cause for liver disease such as chronic viral hepatitis, autoimmune liver disease, short gut, small bowel syndrome, alcohol liver disease, or TPN-related cholestatic disease","ALL",{"count":68,"type":69},70,"ESTIMATED","OBSERVATIONAL","This is a multi-site, retrospective chart review as well as a prospective study to evaluate histopathologic findings in liver samples from individuals with any UCD diagnosis. This study will be conducted at all Urea Cycle Disorders Consortium (UCDC) sites: Baylor College of Medicine in Houston, TX and Children's National Medical Center in Washington D.C.",[73,74,75,76,77,78,79,80,81,82],"Urea Cycle Disorder","Ornithine Transcarbamylase Deficiency","Citrullinemia 1","ARGI Deficiency","ASL Deficiency","Argininosuccinic Aciduria","ASS Deficiency","Hyperargininemia","Carbamyl Phosphate Synthetase Deficiency","NAGS Deficiency",[84,85,86,87],"Liver transplant","Liver disease","Liver biopsy","Histopathology","2025-07-17",{"date":90,"type":91},"2025-07-20","ACTUAL",{"date":93,"type":91},"2022-02-24",{"date":95,"type":69},"2026-06-30",{"name":5,"class":6},2]