[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625617":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":30,"locations":38,"responsibleParty":71,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":21,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":102,"overallStatus":41,"whyStopped":21,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Military University Hospital, Prague","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Participants","EXPERIMENTAL","Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.",[13,14],"Procedure: Hepatic venous pressure gradient measurement","Procedure: Endoscopic ultrasound-guided portal pressure gradient measurement",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"PROCEDURE","Hepatic venous pressure gradient measurement","HVPG measurement is minimally invasive procedure that involves cannulation of the right internal jugular vein, followed by the insertion of a balloon-occlusion catheter into the right or middle hepatic vein to measure both free hepatic vein pressure and wedged hepatic vein pressure, enabling the calculation of HVPG. Additionally, this method allows for liver biopsy during the same session. HVPG is widely regarded as the gold standard for PPG measurement.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Endoscopic ultrasound-guided portal pressure gradient measurement","Recent advancements in the field of digestive endoscopy have introduced an innovative alternative: endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement. This emerging technique shows promise for further improving the accessibility of portal hypertension assessment and also offers the possibility of liver biopsy in one session. EUS-PPG may have several advantages, including its minimally invasive nature, safety profile, high technical success rate, the possibility of a \"one-stopshop\" approach (combining EUS-PPG, liver biopsy, and endoscopic treatment of esophageal varices), absence of radiation exposure.",[9],[27],{"name":28,"affiliation":5,"role":29},"Petr Hříbek, MD, PhD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":34},"CONTACT","+420973203065","petr.hribek@uvn.cz",{"name":36,"role":32,"phone":21,"phoneExt":21,"email":37},"Petr Urbánek, Prof.","petr.urbanek@uvn.cz",[39,58],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":21,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Military University Hospital Prague","RECRUITING","Prague","Bohemia","16902","Czechia",{"type":47,"coordinates":48},"Point",[49,50],14.42076,50.08804,{"lat":50,"lon":49},[53,54,55],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":34},{"name":28,"role":29,"phone":21,"phoneExt":21,"email":21},{"name":56,"role":57,"phone":21,"phoneExt":21,"email":21},"Petr Urbánek, Prof","SUB_INVESTIGATOR",{"facility":59,"status":41,"city":42,"state":21,"zip":21,"country":45,"countryCode":21,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},"IKEM",{"type":47,"coordinates":61},[49,50],{"lat":50,"lon":49},[64,68,69],{"name":65,"role":32,"phone":66,"phoneExt":21,"email":67},"Tomáš Hucl, Prof.","+420236054016","tomas.hucl@ikem.cz",{"name":65,"role":29,"phone":21,"phoneExt":21,"email":21},{"name":70,"role":57,"phone":21,"phoneExt":21,"email":21},"Tomáš Nesnídal, MD",{"type":72,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[74],{"name":75,"class":76},"University Hospital Prague (IKEM), Prague, Czech Republic","UNKNOWN","100625617","hepatic-venous-pressure-gradient-versus-endoscopic-ultrasound-guided-portal-pressure-gradient---comparative-analysis-hepca-100625617",false,"NCT07424963","Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)","Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis","HEPCA","Inclusion Criteria:\n\n* Age 18-75 years at the time of enrollment; signed informed consent\n* Clinical indication for HVPG measurement and\u002For transjugular liver biopsy for chronic advanced liver disease\n\nExclusion Criteria:\n\n* Severe co-morbidities (e.g., advanced chronic heart failure, chronic renal insufficiency stage 4 and above, long-term poorly compensated diabetes mellitus with severe complications)\n* Pregnancy\n* Estimated patient non-compliance and\u002For not signing of the informed consent\n* Documented iodine contrast dye allergy\n* Presence of portal vein thrombosis or cavernomatous transformation of portal vein or hepatic vein obstruction\n* Ascites Grade 3\n* Biliary obstruction\n* Anticoagulation or antiplatelet therapy, which cannot be discontinued\n* INR \\> 1.5 and\u002For platelet count \\\u003C 50,000\u002Fµl\n* Hepatocellular carcinoma in the left lobe of the liver\n* Surgically altered upper gastrointestinal tract anatomy\n* State after transjugular intrahepatic portosystemic shunt\n* State after liver transplantation","ALL","18 Years","75 Years",{"count":89,"type":90},40,"ESTIMATED","INTERVENTIONAL",[93],"NA","The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement.\n\nThe primary question is whether EUS-PPG provides measurements really equivalent to HVPG in terms of gradient accuracy.\n\nParticipants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.",[96,97,98,99,100,101],"Cirrhosis","Portal Hypertension","EUS","Non-Cirrhotic Portal Hypertension","HVPG","Hepatic Venous Pressure Gradient",[100,103,104,105],"EUS-PPG","portal hypertension","liver cirrhosis","2026-02-16",{"date":108,"type":109},"2026-02-20","ACTUAL",{"date":111,"type":109},"2025-05-30",{"date":113,"type":90},"2028-12-31",{"name":5,"class":6},2]