[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634019":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":42,"locations":48,"responsibleParty":64,"collaborators":30,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":30,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":30,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":30,"overallStatus":51,"whyStopped":30,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Lahore","OTHER",[8,14,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional Group (To)","PLACEBO_COMPARATOR","starch capsules",[13],"Dietary Supplement: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Experimental Group (T1)","EXPERIMENTAL","Each capsule contains 250 mg of Reishi mushroom dried powder, to be taken alongside a probiotic-rich diet.",[19,20],"Dietary Supplement: reishi mushroom- (Ganoderma lucidum)","Dietary Supplement: Reishi mushroom dried powder",{"label":22,"type":16,"description":23,"interventionNames":24},"Experimental Group (T2)","Each capsule contains 250 mg of Reishi mushroom dried powder, to be taken twice alongside a probiotic-rich diet.",[19,20],[26,31,35,39],{"type":27,"name":28,"description":17,"armGroupLabels":29,"otherNames":30},"DIETARY_SUPPLEMENT","reishi mushroom- (Ganoderma lucidum)",[15,22],null,{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Placebo","STARCH CAPCULE",[9],{"type":27,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Reishi mushroom dried powder","Reishi mushroom dried powder ONCE A DAY",[15],{"type":27,"name":36,"description":40,"armGroupLabels":41,"otherNames":30},"Reishi mushroom dried powder TWICE A DAY",[22],[43],{"name":44,"role":45,"phone":46,"phoneExt":30,"email":47},"Sana Noreen, PhD","CONTACT","03018661160","sananoreen.rizwan@gmail.com",[49],{"facility":50,"status":51,"city":52,"state":30,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Sana Noreen","RECRUITING","Lahore","54000","Pakistan","PK",{"type":57,"coordinates":58},"Point",[59,60],74.35071,31.558,{"lat":60,"lon":59},[63],{"name":44,"role":45,"phone":46,"phoneExt":30,"email":47},{"type":65,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100634019","hepatoprotective-effects-of-reishi-mushroom--ganoderma-lucidum-among-metabolic-dysfunction-associated-fatty-liver-disease-patients-100634019",false,"NCT07534241","Hepatoprotective Effects of Reishi Mushroom- (Ganoderma Lucidum) Among Metabolic Dysfunction-associated Fatty Liver Disease Patients","Inclusion Criteria:\n\n* Adults aged 35-65 years\n* BMI between 18.5 and 30 kg\u002Fm².\n* Complete Blood Count test ranges, WBC \\\u003C 4,000-11,000 cells\u002FµL, RBC Men \\\u003C 4.5-6.0 \u002F Women 4.0-5.5 million\u002FµL, Hemoglobin: Men \\\u003C 13.5-17.5 \u002F Women 12.0-15.5 g\u002FdL, Platelets \\\u003C 150,000-450,000 cells\u002FµL.\n* Lipid profile test markers (elevated LDL, total cholesterol, or triglycerides less than 150mg\u002FdL high 200-499mg\u002FdL and 500 mg\u002FdL are above high.\n* Liver function test markers, ALT \\> 56 U\u002FL, AST\\>40 U\u002FL, ALP\\>147 UL.\n* Inflammatory markers: CRP \\>3 mg\u002FL, - IL-6 ≥3 pg\u002FmL, TNF-α ≥8 pg\u002FmL.\n* Elevated blood sugar levels, or hyperglycemia, refer to a typically above 126 mg\u002FdL, fasting or 200 mg\u002FdL post-meal.\n\nExclusion Criteria:\n\n* ● Diagnosed with severe cardiovascular disease, liver failure, or renal impairment.\n\n  * Pregnant or lactating women.\n  * Individuals currently on statins, ezetimibe, PCSK9 inhibitors, or any other lipid-lowering therapy.\n  * Allergic to mushrooms.\n  * Diagnosed with celiac disease or other chronic gastrointestinal disorders (e.g., Crohn's disease, ulcerative colitis).\n  * History of malignancy.\n  * Participation in another clinical trial within the last 3 months.",true,"ALL","35 Years","65 Years",{"count":77,"type":78},102,"ESTIMATED","INTERVENTIONAL",[81],"NA","This 12-week RCT investigates the hepatoprotective and immunomodulatory effects of Ganoderma lucidum combined with a probiotic-rich diet in adults with MAFLD, assessing liver enzymes, lipid profile, inflammation, gut microbiota, and oxidative stress.\n\nFindings are expected to show dose-dependent improvements in hepatic fat, insulin resistance, and inflammatory markers, potentially reducing reliance on pharmacotherapy in",[84,85],"Lipid Profile","Liver Biomarkers","2026-04-09",{"date":88,"type":89},"2026-04-16","ACTUAL",{"date":91,"type":89},"2025-10-02",{"date":93,"type":78},"2026-04-15",{"name":5,"class":6},1]