[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588076":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":16,"locations":7,"responsibleParty":22,"collaborators":24,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":7,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":7,"studyType":47,"phases":7,"briefSummary":48,"conditions":49,"keywords":51,"overallStatus":56,"whyStopped":7,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":7},{"fullName":5,"class":6},"Second Affiliated Hospital of Guangzhou Medical University","OTHER",null,[9,13],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Bronchoalveolar Lavage (BAL) via Fiberoptic Bronchoscopy","Bronchoalveolar Lavage (BAL) via Fiberoptic Bronchoscopy\n\n1. Site selection: For patients with limited lesions, the lesion segment was chosen; For patients with diffuse lesions, the right middle lobe or left upper lobe tongue should be severed.\n2. Injecting physiological saline: After the top of the bronchoscope is embedded in the target bronchial segment or subsegment opening, 37 ℃ or room temperature physiological saline is rapidly injected through the operating channel, with a total volume of 60-120ml, injected in batches (20-50ml each time).\n3. Negative pressure suction: After injecting physiological saline, immediately use appropriate negative pressure (generally recommended below 100mmHg) to suction and obtain BALF, with a total recovery rate of ≥ 30%.\n4. BALF collection: Specimens used for pathogen analysis need to be collected in sterile containers; Cytological analysis requires the selection of plastic containers or siliconized glass containers to reduce cell adhesion.",{"type":10,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"throat Swab","A throat swab is a diagnostic sampling technique used to collect microbial specimens from the oropharynx and tonsillar areas. The standardized procedure involves:\n\n1. Positioning the patient with their head tilted slightly backward;\n2. Using a sterile, synthetic-fiber swab with a plastic shaft (avoiding calcium alginate or wooden shafts);\n3. Vigorously rubbing the swab over both tonsillar pillars and the posterior pharyngeal wall while avoiding contact with the tongue, teeth, or uvula;\n4. Immediately placing the swab into appropriate transport media viral\u002Fbacterial);\n5. Maintaining cold chain (2-8°C) for specimen transport if required.",[17],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},"Lili L Tao","CONTACT","+8613535107553","taollicu@163.com",{"type":23,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[25,27,29,32],{"name":26,"class":6},"Guangzhou Red Cross Hospital",{"name":28,"class":6},"Guangzhou First People's Hospital",{"name":30,"class":31},"Gongguan People's Hospital","UNKNOWN",{"name":33,"class":6},"Guangzhou Medical University","100588076","herpes-simplex-virus-type-1-infectionreactivation-of-patients-with-severe-pneumoniathe-hsv-sp-study-100588076",false,"NCT06936683","Herpes Simplex Virus Type 1 Infection\u002FReactivation of Patients With Severe Pneumonia（the HSV-SP Study）","Prognostic Effect of Herpes Simplex Virus Type 1 Infection\u002FReactivation in the Lower Respiratory Tract of Critical Care Patients With Severe Pneumonia（the HSV-SP Study）: a Study Protocol for a Multicenter, Prospective Cohort Study","Inclusion Criteria:\n\n* 1: Age\\>18 years old. 2: Clinical diagnosis for severe pneumonia. 3: ICU stay time \\>72 hours. 4: A written informed consent form was obtained from the members of the patients' family.\n\nExclusion Criteria:\n\n* 1: severe ventilation dysfunction, and effective respiratory support has not been used; 2: Aortic aneurysm and esophageal varices at risk of rupture; 3: Recent acute coronary syndrome, uncontrolled severe hypertension, and malignant arrhythmia; 4: Irreversible bleeding tendencies, such as severe coagulation dysfunction, massive hemoptysis, or gastrointestinal bleeding; 5: Multiple pulmonary bullae at risk of rupture. 6: Estimated survival time\\\u003C24 hours. 7: Included in another interventional clinical study.","ALL","18 Years","100 Years",{"count":45,"type":46},323,"ESTIMATED","OBSERVATIONAL","Severe pneumonia(SP) is a one of the main causes of death for critically ill patients.Samples of bronchoalveolar lavage fluid (BALF) from SP patients often report positive for herpes simplex virus type 1 (HSV-1) DNA. However, to date, it is unclear the impact and significance of this positive result on SP patients. This study will evaluate the prognostic impact of lower respiratory tract HSV-1 infection\u002Freactivation on ICU severe pneumonia patients.At the same time, by analyzing the risk factors that affect prognosis, we will identify populations with the potential for intervention benefits and provide a basis for further intervention treatment.",[50],"Severe Pneumonia",[52,53,54,55],"Severe pneumonia","Herpes simplex virus type 1","infection\u002Freactivation","Prognostic effect","NOT_YET_RECRUITING","2025-04-22",{"date":59,"type":60},"2025-04-25","ACTUAL",{"date":62,"type":46},"2025-06-01",{"date":64,"type":46},"2027-10-01",{"name":5,"class":6}]