[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582263":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":54,"collaborators":20,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":20,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":78,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Centre Leon Berard","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Clinical-biological cohort","A clinical-biological cohort of 50 patients with OSCC.\n\nBlood sample and biospecimen at the time of a standard surgery.",[12,13],"Procedure: Biospecimen","Procedure: Blood sampling",[15,21],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Biospecimen","* 1 or 2 tumoral specimen (depending on the size of the tumor)\n* 1 specimen of the healthy oral mucosa\n* 1 leucoplakia specimen if applicable.\n\nThe biospecimens will be collected at the time of the surgery organised for the standard routine medical care.",[9],null,{"type":16,"name":22,"description":23,"armGroupLabels":24,"otherNames":20},"Blood sampling","Blood sampling (6 mL), taken from a routine biological exam.",[9],[26],{"name":27,"affiliation":28,"role":29},"Philippe Zrounba, M.D.","philippe.zrounba@lyon.unicancer.fr","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":34,"email":28},"CONTACT","(0)4 69 85 60 82","+33",{"name":36,"role":32,"phone":37,"phoneExt":34,"email":38},"Karène Mahtouk, Ph.D.","04 69 85 60 82","karene.mahtouk@lyon.unicancer.fr",[40],{"facility":41,"status":20,"city":42,"state":20,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Centre Léon Bérard","Lyon","69008","France","FR",{"type":47,"coordinates":48},"Point",[49,50],4.84789,45.74906,{"lat":50,"lon":49},[53],{"name":27,"role":32,"phone":20,"phoneExt":20,"email":28},{"type":55,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100582263","heterogeneity-of-oral-squamous-cell-carcinoma-analysis-by-single-cell-rna-sequencing-100582263",false,"NCT06861036","Heterogeneity of Oral Squamous Cell Carcinoma Analysis by Single Cell RNA Sequencing","HOASIS","Inclusion Criteria:\n\n* I1. Male or female at least 18 years old.\n* I2. Patient with OSCC and undergoing surgery at the Centre Léon Bérard.\n* I3. Patient who has agreed to participate in this research and sign consent.\n* I4. Patient affiliated to a medical insurance.\n\nExclusion Criteria:\n\n* NI1. Pregnant or nursing woman.\n* NI2. Contraindication to general anesthesia.\n* NI3. Suspicion of rare tumor of particular histology other than squamous cell carcinoma (Sarcoma...).\n* NI4. Patient under curatorial or guardianship or placed under the protection of justice.","ALL","18 Years",{"count":66,"type":67},50,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients.",[73],"Oral Squamous Cell Carcinomas",[75,76,77],"scRNAseq","Heterogeneity of all cell population","OSCC","NOT_YET_RECRUITING","2025-02-28",{"date":81,"type":82},"2025-03-06","ACTUAL",{"date":84,"type":67},"2025-05-15",{"date":86,"type":67},"2028-05-15",{"name":5,"class":6},1]