[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100395540":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":29,"locations":20,"responsibleParty":35,"collaborators":20,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":20,"eligibilityCriteria":43,"healthyVolunteers":40,"sex":44,"minAge":45,"maxAge":20,"enrollmentInfo":46,"targetDuration":20,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":58,"whyStopped":20,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":20},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Controlled Dietary Study","EXPERIMENTAL","Participants will consume the controlled diet for five days and be administered an intravenous (IV) load of glycolate. Participants will provide urine and blood samples both before the glycolate load to establish baseline levels and after the glycolate load to measure oxalate levels afterwards.",[13,14],"Other: Controlled Diet","Other: Glycolate Administration",[16,21],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"Controlled Diet","Participants will consume a controlled low oxalate diet for five days.",[9],null,{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":20},"Glycolate Administration","Participants will come to the UAB Clinical Research Unit (CRU) and be administered a glycolate load via intravenous (IV) catheter.",[9],[26],{"name":27,"affiliation":5,"role":28},"Kyle Wood, MD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":20,"email":34},"Demond Wiley","CONTACT","205-934-3671","kidneystone@uabmc.edu",{"type":28,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Kyle D. Wood","Principal Investigator","100395540","heterozygous-individuals-for-agxt-and-kidney-stones-100395540",false,"NCT04430426","Heterozygous Individuals for AGXT and Kidney Stones","Inclusion Criteria:\n\n* at least 18 years of age\n* history of calcium oxalate stones\n* heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel\n* willingness to comply with a controlled diet for five days\n\nExclusion Criteria:\n\n* pregnant individuals\n* individuals who are currently breast feeding","ALL","18 Years",{"count":47,"type":48},4,"ESTIMATED","INTERVENTIONAL",[51],"NA","This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies. Subjects will then be administered an intravenous (IV) load of glycolate, providing additional blood and urine samples afterwards to measure any increase in oxalate levels.",[54],"Kidney Stone",[56,57],"kidney stone","oxalate","NOT_YET_RECRUITING","2026-05-28",{"date":61,"type":62},"2026-05-29","ACTUAL",{"date":64,"type":48},"2026-07-01",{"date":66,"type":48},"2032-08-01",{"name":5,"class":6}]