[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534679":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":40,"locations":50,"responsibleParty":66,"collaborators":31,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":31,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":31,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":52,"whyStopped":31,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Anhui Medical University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Unilateral real High definition transcranial direct current stimulation","ACTIVE_COMPARATOR","The left electrical stimulation cathode was placed over CP5 with return electrodes placed at FT7, C1, P03 and P9 . The right electrical stimulation cathode was placed over CP6 with return electrodes placed at FT8, C2, PO4 and P10 .\n\nIn the unilateral treatment group, HD-tDCS treatment based on Epileptic discharge is placed on either the left or right side of the brain.Ten 2-mA sessions were applied for 30 minutes,once a day over 10 consecutive workdays.",[13],"Device: Active Comparator: Unilateral real High definition transcranial direct current stimulation",{"label":15,"type":10,"description":16,"interventionNames":17},"Bilateral real High definition transcranial direct current stimulation","The left electrical stimulation cathode was placed over CP5 with return electrodes placed at FT7, C1, P03 and P9 . The right electrical stimulation cathode was placed over CP6 with return electrodes placed at FT8, C2, PO4 and P10 .\n\nIn the bilateral treatment group, HD-tDCS treatment was placed on the left and right sides of the brain, at least eight hours apart.. Twenty 2-mA sessions (ramp-up and ramp-down periods of 30 and 30 seconds, respectively) were applied for 30 minutes,twice a day over 10 consecutive workdays.",[18],"Device: Active Comparator: Bilateral real High definition transcranial direct current stimulation",{"label":20,"type":21,"description":22,"interventionNames":23},"Sham High definition transcranial direct current stimulation","SHAM_COMPARATOR","The left electrical stimulation cathode was placed over CP5 with return electrodes placed at FT7, C1, P03 and P9 . The right electrical stimulation cathode was placed over CP6 with return electrodes placed at FT8, C2, PO4 and P10.\n\nThe 30 subjects were randomly divided into two groups, 15 receiving bilateral Sham HD-tDCS and 15 receiving unilateral Sham HD-tDCS.\n\nSham HD-tDCS was delivered using the same protocol and current intensity, but the period of active stimulation was only during the ramp-up and ramp-down periods of 30 and 30 seconds.",[24],"Device: Sham Comparator: Sham High definition transcranial direct current stimulation",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Active Comparator: Unilateral real High definition transcranial direct current stimulation","Improvement of cortical excitability, unilateral stimulation was effective, and no side effects were observed",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Active Comparator: Bilateral real High definition transcranial direct current stimulation","Improved cortical excitability, the effect was more obvious than unilateral stimulation, the effect lasted longer, and no side effects were observed",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Sham Comparator: Sham High definition transcranial direct current stimulation","The sham stimulation is mainly used for blank control, control variables, and exclude the interference of other factors",[20],[41,46],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},"Kai Wang, PhD","CONTACT","+86-0551-62923704","wangkai1964@126.com",{"name":47,"role":43,"phone":48,"phoneExt":31,"email":49},"Xingui Chen, PhD","+8615955161468","chen_xin_gui@126.com",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":31,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Hefei","Anhui","China","CN",{"type":58,"coordinates":59},"Point",[60,61],117.28083,31.86389,{"lat":61,"lon":60},[64,65],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},{"name":47,"role":43,"phone":48,"phoneExt":31,"email":49},{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","WANG KAI","Director of medical psychological department, Anhui Medical University","100534679","high-definition-transcranial-direct-current-stimulation-hd-tdcs-for-refractory-epilepsy-100534679",false,"NCT06241963","High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy","The Efficacy, Safety and Mechanism of High Definition Transcranial Direct Current Stimulation (HD-tDCS) in the Treatment of Refractory Epilepsy","Inclusion Criteria:\n\n* Clinical diagnosis of refractory epilepsy\n* Right-handed and aged 18-50 years old and primary school education or above;\n* No major neurological or mental illness, no head injury, alcohol dependence or drug dependence;\n* During the experiment, the subjects did not smoke, drink, get sick and take psychotropic drugs, and there were no major life events that caused mood changes.\n\nExclusion Criteria:\n\n* organic brain injury, neurological diseases or serious physical diseases;\n* Have a history of substance abuse and drug dependence, or have used antipsychotic drugs in the past three months, and have serious suicidal tendencies;\n* There are contraindications for MRI or EEG or transcranial magnetic stimulation.","ALL","18 Years","50 Years",{"count":81,"type":82},90,"ESTIMATED","INTERVENTIONAL",[85],"NA","To observe the clinical effect and safety of transcranial electrical stimulation on patients with refractory epilepsy before and after treatment and analyze its therapeutic mechanism.",[88,89,90,91,92],"Transcranial Direct Current Stimulation","EEG","Functional Magnetic Resonance Imaging","Refractory Epilepsy","Transcranial Magnetic Stimulation",[91,90,89,94],"Transcranial magnetic stimulation","2024-02-15",{"date":97,"type":98},"2024-02-20","ACTUAL",{"date":100,"type":82},"2024-02-12",{"date":102,"type":82},"2026-06-30",{"name":5,"class":6},1]