[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641069":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":43,"collaborators":48,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":81,"whyStopped":11,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intraoperative application of high-density flexible ECoG-Guided Resection","EXPERIMENTAL",null,[13],"Device: High-density Flexible Electrocorticography",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DEVICE","High-density Flexible Electrocorticography","During resective epilepsy surgery, a sterile high-density flexible electrocorticography will be placed on the exposed cortical surface over the suspected epileptogenic zone and adjacent cortex. The array will be used for high-spatial-resolution intraoperative ECoG recording and real-time analysis of epileptiform activity, including interictal spikes, high-frequency oscillations, spatial discharge gradients, and propagation patterns. The intraoperative ECoG findings will be provided to the surgical team to assist in defining the epileptogenic zone and tailoring the extent of resection. The high-density ECoG is used for intraoperative recording only and will be removed before wound closure.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Kai Zhang Dr","CONTACT","86 01059975051","zhangkai62035@sina.com",[27],{"facility":5,"status":11,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Beijing","Beijing Municipality","100070","China","CN",{"type":34,"coordinates":35},"Point",[36,37],116.39723,39.9075,{"lat":37,"lon":36},[40],{"name":41,"role":23,"phone":24,"phoneExt":11,"email":42},"Du Cai Dr","ferryc22@163.com",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":47,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Kai Zhang","Dr.","Beijing Neurosurgical Institute",[49,52,54,56,58],{"name":50,"class":51},"Beijing Fengtai Hospital","UNKNOWN",{"name":53,"class":6},"Peking University First Hospital",{"name":55,"class":6},"The Chinese University of Hong Kong, Shenzhen",{"name":57,"class":51},"Beijing Xinzhida Neural Technology Co., Ltd",{"name":47,"class":6},"100641069","high-density-flexible-ecog-for-epilepsy-surgery---a-single-arm-ect-100641069",false,"NCT07656857","High-density Flexible ECoG for Epilepsy Surgery - A Single-Arm ECT","Precision Resection of the Epileptogenic Zone Using Intraoperative Subdural High-density Flexible Electrocorticography - A Single-Arm Trial With an External Historical Control Cohort","PRECISE","Inclusion Criteria:\n\n1. Aged 3 to 60 years.\n2. Diagnosed with drug-resistant epilepsy, defined as persistent seizures despite treatment with two or more appropriately selected, adequately dosed, and adequately tried antiseizure medications.\n3. Diagnosed with focal epilepsy after a standard presurgical epilepsy evaluation and considered suitable for resective epilepsy surgery.\n4. Preoperative Mini-Mental State Examination (MMSE) score ≥ 24.\n5. Able to provide written informed consent, or written informed consent provided by a legal guardian when applicable.\n\nExclusion Criteria:\n\n1. Suspected mesial temporal lobe epilepsy after multidisciplinary presurgical evaluation.\n2. History of any previous neurosurgical craniotomy before epilepsy surgery.\n3. Severe psychiatric, cognitive, or psychological disorder that prevents participation in the study or completion of follow-up.\n4. Contraindication to surgery.","ALL","3 Years","60 Years",{"count":71,"type":72},85,"ESTIMATED","INTERVENTIONAL",[75],"NA","What's the clinical value of high-density flexible electrocorticography (ECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?",[78],"Focal Epilepsy",[80,17],"Epilepsy surgery","NOT_YET_RECRUITING","2026-06-15",{"date":84,"type":85},"2026-06-18","ACTUAL",{"date":87,"type":72},"2026-07-01",{"date":89,"type":72},"2028-12-31",{"name":5,"class":6},1]