[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100392795":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":70,"collaborators":26,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":26,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":26,"enrollmentInfo":81,"targetDuration":26,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"King Chulalongkorn Memorial Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-dose oral PPI","EXPERIMENTAL","Omeprazole 80 mg\u002Fday (40 mg twice a day) per oral route for 72 hours",[13],"Drug: High-dose oral omeprazole",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard IV PPI","ACTIVE_COMPARATOR","Pantoprazole 8 mg\u002Fhour IV continuous drip for 72 hours",[19],"Drug: Standard IV PPI",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","High-dose oral omeprazole","Local made oral omeprazole 40 mg twice daily will be prescribed for 72 hours after randomization.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Pantoprazole 8mg\u002Fhour IV continuous drip will be prescribed for 72 hours after randomization",[15],[31],{"name":32,"affiliation":5,"role":33},"Rapat Pittayanon, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":26,"email":38},"CONTACT","66804224999","rapat125@gmail.com",[40,56],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Pathum Wan","Bangkok","10330","Thailand","TH",{"type":48,"coordinates":49},"Point",[50,51],100.52329,13.73698,{"lat":51,"lon":50},[54],{"name":55,"role":36,"phone":26,"phoneExt":26,"email":38},"Rapat Pittayanon",{"facility":57,"status":41,"city":58,"state":26,"zip":59,"country":45,"countryCode":46,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Surin Hospital","Surin","32000",{"type":48,"coordinates":61},[62,63],103.49364,14.88181,{"lat":63,"lon":62},[66],{"name":67,"role":36,"phone":68,"phoneExt":26,"email":69},"Nutbordee Nalinthassanai, MD","6644511757","nutbordee@gmail.com",{"type":33,"investigatorFullName":55,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Principle investigator, Gastrointestinal Unit","100392795","high-dose-oral-omeprazole-in-high-risk-ugib-100392795",false,"NCT04394663","High Dose Oral Omeprazole in High Risk UGIB","High Dose Oral Omeprazole Versus Standard Continuous Intravenous Pantoprazole in Patient With Peptic Ulcer Bleeding and Undergo Successful Therapeutic Endoscopy; Non-inferiority Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with peptic ulcer bleeding and endoscopic finding show ulcer with Forrest classification Ia (spurting haemorrhage), IIa (oozing haemorrhage), Ib (non-bleeding visible vessel)\n* Age \\> 18 years old\n\nExclusion Criteria:\n\n* Deny to participate\n* Pregnancy or lactation\n* Low risk peptic ulcer bleeding including clean base ulcer, flat pigmented spot\n* Non-peptic ulcer bleeding eg. erosive gastritis\u002Fduodenitis, Mallory Weiss tear, esophageal\u002Fgastric\u002Fduodenal varices, vascular lesions (eg. Dieulafoy) , malignant ulcer\n* Bleeding tendency\n* Terminal stage of cancer\n* ESRD on hemodialysis\n* Decompensated liver cirrhosis","ALL","18 Years",{"count":82,"type":83},128,"ESTIMATED","INTERVENTIONAL",[86],"NA","Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding. Intravenous PPI is recommended as a standard treatment. In the past, there were many trials showing the efficacy of high-dose oral PPI after endoscopic hemostasis but most were industrial sponsor which assessing an expensive PPI. Moreover, the number of patients in those studies were insufficient to confirm a non-inferiority outcome in term of rebleeding by using oral PPI. This study will evaluate a high-dose, local-made PPI (omeprazole) in peptic ulcer treatment after successful endoscopic hemostasis compared to standard IV PPI continuous drip in term of rebleeding, as well as 24-hour gastric pH monitoring.",[89],"GI Bleeding",[91],"oral proton pump inhibitor","2025-09-12",{"date":94,"type":95},"2025-09-18","ACTUAL",{"date":97,"type":95},"2020-10-01",{"date":99,"type":83},"2025-12-31",{"name":5,"class":6},2]