[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605169":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":49,"collaborators":25,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":25,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":25,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":25,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High Flow Nasal Cannula Oxygenation","EXPERIMENTAL","High Flow Nasal cannula is a system to deliver heated and humidified oxygen with an inspired oxygen fraction between 21 and 100% through large bore nasal cannula. The system delivers a flow up to 60 liters\u002Fmin.",[13],"Procedure: High Flow Nasal Cannula Oxygenation",{"label":15,"type":16,"description":17,"interventionNames":18},"Mask Oxygenation","ACTIVE_COMPARATOR","Conventional Oxygenation will be administered through mask",[19],"Procedure: Face Mask Oxygenation",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","High Flow Nasal Cannula will be set at 60 liters per minute of air\u002Foxygen admixture to reach a peripheral oxygen saturation equal or greater than 94%",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Face Mask Oxygenation","conventional oxygen therapy will be administered through common mask with a flow up to 6 Liters per minute",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Wenling Zhao","CONTACT","+86-18321299017","zhao.wenling@zs-hospital.sh.cn",[37],{"facility":38,"status":39,"city":40,"state":25,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":25},"Zhongshan Hospitla","RECRUITING","Shanghai","China","CN",{"type":44,"coordinates":45},"Point",[46,47],121.45806,31.22222,{"lat":47,"lon":46},{"type":50,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100605169","high-flow-nasal-cannula-and-mask-oxygenation-in-patients-with-visceral-obesity-undergoing-sedated-gastroscopy-100605169",false,"NCT07159022","High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy","High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* ASA class ≤Ⅲ\n* Visceral obesity（body mass index≥28 and BRI ≥5.46）\n* Patients who will undergo sedated gastroscopy\n\nExclusion Criteria:\n\n* Life-threatening heart disease or acute myocardial infarction within 6 weeks\n* Presence of pneumothorax or pulmonary bullae, pulmonary embolism, pulmonary oedema\n* Upper respiratory tract infection\n* Presence of tracheostomy\n* Nasal or nasopharyngeal diseases\n* Coagulation disorders or a tendency of nose bleeding\n* Pregnancy\n* Recent (within 1 week) thoracic surgery\n* Emergent procedure or surgery\n* Allergy to drugs used during the procedure\n* Unwillingness to participate in the study",true,"ALL","18 Years","80 Years",{"count":63,"type":64},200,"ESTIMATED","INTERVENTIONAL",[67],"NA","During sedated gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce respiratory depression, airway obstruction, and decreased chest wall compliance. Patients with obesity, especially visceral fat, have poor lung and chest wall compliance, lower lung capacity and functional residual capacity, and an unbalanced ventilation-to-perfusion ratio. Thus, obese patients are at a high risk of hypoxemia.\n\nIncreasing evidence supports the use of High-flow nasal cannula (HFNC) oxygenation in obese patients during sedated gastrointestinal endoscopy. Obesity, especially visceral obesity, is an established risk factor associated with all-cause mortality. Body roundness index (BRI) is a newer anthropometric measure associated with identification of high-risk individuals. Owing to the limited evidence, we designed this unblinded randomized controlled trial to assess whether HFNC, compared to standard mask oxygenation, improves oxygenation at the end of the procedure (primary endpoint) in patients with visceral obesity.",[70,71],"High Flow Nasal Cannula","Body Roundness Index","2025-11-27",{"date":74,"type":75},"2025-12-01","ACTUAL",{"date":77,"type":75},"2025-08-31",{"date":79,"type":64},"2026-07-31",{"name":5,"class":6},1]