[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553691":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":11,"responsibleParty":38,"collaborators":11,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":44,"sex":50,"minAge":51,"maxAge":11,"enrollmentInfo":52,"targetDuration":11,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":11,"overallStatus":61,"whyStopped":11,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":11},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"standard oxygen","ACTIVE_COMPARATOR",null,[13],"Other: standard oxygen",{"label":15,"type":16,"description":11,"interventionNames":17},"high flow nasal oxygen","EXPERIMENTAL",[18],"Device: high flow nasal cannula",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","high flow nasal cannula","humidified and heated oxygen",[15],{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":11},"oxygen delivery through Venturi mask",[9],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Francesco Franceschi, MD","CONTACT","+390630156627","francesco.franceschi@policlinicogemelli.it",{"name":35,"role":31,"phone":36,"phoneExt":11,"email":37},"Gianluca Tullo, MD","+393926595850","gianlucatullo@gmail.com",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","FRANCESCHI FRANCESCO","Professor","100553691","high-flow-nasal-oxygen-for-acute-hypoxemic-respiratory-failure-in-the-emergency-room-100553691",false,"NCT06489379","High Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure in the Emergency Room","High Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure in the Emergency Room: the GLAMOUR Study","GLAMOUR","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* PaO2\u002FFiO2 ratio between 250 and 150 mmHg or SpO2\u002FFiO2 ratio between 190 and 274, after at least 15 minutes of spontaneous breathing through a Venturi mask (VM), with a FiO2 targeted at a SpO2 94-97%;\n* Respiratory rate(RR)≤35breaths\u002Fmin,afteratleast15minutesofspontaneous breathing through a VM, with a FiO2 targeted at a SpO2 94-97%;\n* PaCO2 ≤ 45 mmHg;\n* Unilateral or bilateral infiltrate(s), as detected with chest radiography and\u002For computed tomography and\u002For with lung ultrasound not fully explained by effusions, atelectasis, or nodules\u002Fmasses. Infiltrates at lung ultrasound are defined as presence of focal B-lines, consolidations (with irregular marginal contour, air bronchogram, air trapping sign) and irregularity of the pleural line.\n\nExclusion Criteria:\n\n* Respiratory failure due to:\n\n  * Acute asthma or COPD exacerbation,\n  * Cardiac failure or fluid overload as primary cause of respiratory failure;\n* Unstable angina or ongoing acute myocardial infarction;\n* Acute respiratory acidosis with pH \\\u003C 7.35 and PaCO2 \\> 45 mmHg;\n* Hemodynamic instability and\u002For use of vasopressors\u002Finotropes;\n* Altered mental status (Kelly \\>3), see Figure 1;(18)\n* Contraindications to NIV (high risk of aspiration pneumonia, impaired airways protection, head-facial trauma and\u002For burns, uncooperative patient, cranial\u002Fthoracic\u002Fabdominal open wounds);\n* Indications to urgent intubation performed according to the clinician in charge;\n* Body Mass Index \\> 35 kg\u002Fm2;\n* Pregnancy;\n* Patient's refusal to participate.","ALL","18 Years",{"count":53,"type":54},234,"ESTIMATED","INTERVENTIONAL",[57],"NA","The aim of this multicenter, randomized, controlled, open-label trial is to investigate the efficacy of early treatment with HFNO compared with SOT in preventing early deterioration of patients admitted to the ER because of acute hypoxemic respiratory failure.",[60],"Respiratory Distress Syndrome, Adult","NOT_YET_RECRUITING","2024-07-03",{"date":64,"type":65},"2024-07-05","ACTUAL",{"date":67,"type":54},"2024-07",{"date":69,"type":54},"2026-07",{"name":5,"class":6}]