[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100350992":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":16,"centralContacts":21,"locations":30,"responsibleParty":52,"collaborators":7,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":7,"enrollmentInfo":64,"targetDuration":7,"studyType":67,"phases":7,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":33,"whyStopped":7,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"London North West Healthcare NHS Trust","OTHER",null,[9,13],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Standard echocardiography","Patients will undergo standard echocardiography, with and without contrast",{"type":6,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"High frame rate echocardiography","Following standard echocardiography, the test is repeated using high frame rate ultrasound",[17],{"name":18,"affiliation":19,"role":20},"Roxy Senior, MD","LONDON NORTH WEST UNIVERSITY HEALTHCARE NHS TRUST","PRINCIPAL_INVESTIGATOR",[22,27],{"name":23,"role":24,"phone":25,"phoneExt":7,"email":26},"Emma Howard, MSc","CONTACT","+442088692547","emma.howard16@nhs.net",{"name":28,"role":24,"phone":25,"phoneExt":7,"email":29},"Lasha Gvinianidze, MD","lasha.gviniandze1@nhs.net",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"London North West University Healthcare NHS Trust","RECRUITING","Harrow","Middx","HA1 3UJ","United Kingdom","UK",{"type":40,"coordinates":41},"Point",[42,43],-0.33208,51.57835,{"lat":43,"lon":42},[46,49],{"name":47,"role":24,"phone":7,"phoneExt":7,"email":48},"Sunder Chita","sunderchita@nhs.net",{"name":50,"role":24,"phone":7,"phoneExt":7,"email":51},"Nana Theodorou","nana.theodorou1@nhs.net",{"type":53,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100350992","high-frame-rate-ultrasound-in-heart-disease-assessment-100350992",false,"NCT03850015","High Frame Rate Ultrasound in Heart Disease Assessment","High Frame Rate Contrast Enhanced-ultrasound for the Assessment of Ischaemic Heart Disease","RUFUS-Heart","Inclusion criteria Either\n\n* Ability to give informed consent\n* age ≥18years and\n* confirmed inducible wall motion \u002F perfusion abnormality on previous stress echocardiogram\n* known coronary artery disease - defined by presence of flow-limiting coronary stenosis(\\>70% diameter stenosis) on coronary angiography.\n\nOR\n\n• patient who has been assessed as at low risk of having coronary heart disease\n\nExclusion Criteria:\n\n* Inability to undertake pharmacological stress, ie previously known intolerance to dipyridamole;\n* Moderate or Severe aortic or mitral regurgitation or severe mitral stenosis;\n* Significant pulmonary disease like severe COPD or pulmonary fibrosis;\n* Atrial fibrillation;\n* Inability to provide informed consent;\n* Pregnancy and lactation;\n* Known allergy to Sonovue\n* Patients with second and third degree heart block, unless they have a pacemaker fitted\n* Systolic BP \\\u003C 90\n* Known Myasthenia Gravis\n* Bronchial asthma","ALL","18 Years",{"count":65,"type":66},25,"ESTIMATED","OBSERVATIONAL","The study will compare standard ultrasound images to high frame rate ultrasound images in patients with heart disease or with a low risk of heart disease to see if a higher frame rate of ultrasound adds to the information obtained from standard ultrasound.",[70],"Coronary Artery Disease",[72],"echocardiography","2025-05-21",{"date":75,"type":76},"2025-05-23","ACTUAL",{"date":78,"type":76},"2022-02-01",{"date":80,"type":66},"2025-09-30",{"name":5,"class":6},1]