[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622473":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":38,"centralContacts":43,"locations":53,"responsibleParty":66,"collaborators":69,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":48,"enrollmentInfo":82,"targetDuration":48,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":102,"whyStopped":48,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Helsinki University Central Hospital","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"sBCC","EXPERIMENTAL","Superficial basal cell carcinoma",[13,14],"Device: High Intensity Focused Ultrasound","Procedure: Cryotherapy",{"label":16,"type":10,"description":17,"interventionNames":18},"nBCC","Nodular basal cell carcinoma",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"BD","Bowen's disease",[13,14],[24,31],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DEVICE","High Intensity Focused Ultrasound","High intensity focused ultrasound",[20,16,9],[30],"HIFU",{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"PROCEDURE","Cryotherapy","Liquid nitrogen cryotherapy",[20,16,9],[37],"CRYO",[39],{"name":40,"affiliation":41,"role":42},"Sari Koskenmies, Head of Department","Helsinki University Hospital, Skin and Allergy Hospital, Dermatologic procedure unit","PRINCIPAL_INVESTIGATOR",[44,50],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"Clinical Investigator","CONTACT","+358401986550",null,"jussi.salonen@hus.fi",{"name":45,"role":46,"phone":51,"phoneExt":48,"email":52},"+358504287980","mari.salmivuori@hus.fi",[54],{"facility":55,"status":48,"city":56,"state":48,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":48},"HUS Iho- ja allergiasairaala","Helsinki","00250","Finland","FI",{"type":61,"coordinates":62},"Point",[63,64],24.93545,60.16952,{"lat":64,"lon":63},{"type":67,"investigatorFullName":68,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"SPONSOR_INVESTIGATOR","Jussi Salonen",[70],{"name":71,"class":6},"HUS Skin and Allergy Hospital","100622473","high-intensity-focused-ultrasound-vs-cryotherapy-in-the-treatment-of-basal-cell-carcinomas-and-bowens-disease-in-adults-100622473",false,"NCT07384078","High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults","HIFU vs. CRYO - High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease - a Randomized Controlled Trial","HIFUvsCRYO","Inclusion Criteria:\n\n* age 18 years or older at the time of informed consent\n* ability to give informed consent and comply with the treatment protocol and follow-up plan\n* study lesion located between neck and knees\n* one of following histologically confirmed diagnosis: Superficial BCC with maximum diameter of 2.0 cm \u002F Nodular BCC with max. diameter of 1.5 cm \u002F BD with max. diameter of 2.0 cm\n\nExclusion Criteria:\n\n* Study lesion location in face, head, genitals, hands, or below the knee\n* Clinical\u002Fdermoscopical\u002Fhistological feature for high-risk\u002Faggressive BCC\n* Clinical\u002Fhistological sign for hypertrophic BD\n* Clinical\u002Fdermoscopical\u002Fhistological feature for Squamous cell carcinoma\n* Gorlin Golz syndrome\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":83,"type":84},294,"ESTIMATED","INTERVENTIONAL",[87],"NA","This prospective, randomized, controlled, and single-blinded non-inferiority clinical trial compare the efficacy and tolerability of high intensity focused ultrasound (HIFU) to standard cryotherapy in the treatment of low-risk basal cell carcinomas (BCCs) and Bowen's disease (BD) in adults. The main questions it aims to answer are:\n\n* Is HIFU an efficient treatment option for BCCs and BD?\n* What medical problems do participants get after HIFU?\n\nResearchers will compare HIFU to standard cryotherapy with liquid nitrogen to see if the ultrasound works to treat these local and low-risk non-melanosytic skin cancers.\n\nParticipants will:\n\n* Be treated either with HIFU (intervention) or cryotherapy (control).\n* Visit the clinic 4 weeks, 1-, 3- and 5 years after the treatment for check-ups, tests and survey questions.",[90,91,92,93,20],"Superficial Basal Cell Carcinoma","Nodular Basal Cell Carcinoma","Bowen's Disease","BCC",[30,95,96,97,98,21,99,100,101],"cryo","cryotherapy","high intensity focused ultrasound","basal cell carcinoma","superficial basal cell carcinoma","nodular basal cell carcinoma","non-surgical treatment","NOT_YET_RECRUITING","2026-01-26",{"date":105,"type":106},"2026-02-03","ACTUAL",{"date":108,"type":84},"2026-04-01",{"date":110,"type":84},"2032-12-31",{"name":68,"class":6},1]