[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053683":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":59,"collaborators":30,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":30,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":30,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":30,"overallStatus":81,"whyStopped":30,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Horus University","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"high intensity interval training and Mediterranean diet","EXPERIMENTAL","This study will involve 20 patients with Non-alcoholic Fatty Liver disease undergoing individualized High-Intensity Interval Training for 12 weeks. The exercise regimen includes 3 sessions per week, featuring 3 sets of 3 minutes of high-intensity intervals at 70-90% heart rate reserve, with 2 minutes of active recovery between intervals. All exercise will be supervised on a treadmill, complemented by a Mediterranean diet.",[13,14],"Other: High intensity interval training","Other: Mediterranean diet",{"label":16,"type":10,"description":17,"interventionNames":18},"moderate intensity continous training and Mediterranean diet","This group will include 20 patients with non-alcoholic Fatty Liver disease they will receive moderate intensity continous training protocol consisted of 3× 3 min of moderate -intensity intervals at 40- 60% heart rate reserve for 30 min, in addition to Mediterranean diet.",[19,14],"Other: moderate intensity continuous training",{"label":21,"type":22,"description":23,"interventionNames":24},"Mediterranean Diet","ACTIVE_COMPARATOR","It is characterized by a high consumption of plant-based foods, such as vegetables, fruits, whole grains, seeds, nuts and legumes, and moderate consumption of protein-source foods such as fish and poultry. This diet is rich in monounsaturated fatty acids primarily from olive oil and olives, reduced fat dairy products and low red meat intake.",[14],[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"High intensity interval training","Patients will engage in high-intensity interval training using heart rate reserve (HRR) to determine exercise intensity. The program includes three sessions per week for 12 weeks, featuring three 3-minute high-intensity intervals at 70-90% HRR, with 2 minutes of active recovery in between. Each 30-minute session will be treadmill-based under supervision, incorporating warm-up and cool-down periods. Participants will also follow a Mediterranean diet.",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"moderate intensity continuous training","The program will be in form of:\n\n* Frequency: 3 sessions\u002Fweek for 12 weeks.\n* Intensity: Moderate intensity continues training at 40- 60% HRR.\n* Duration: the session will last 30 minutes per session. Patients will be instructed to follow Mediterranean Diet.",[16],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Mediterranean diet","the composition of the Mediterranean diet, emphasizing that vegetables and fruits make up the largest portion at 35%, followed by whole grains (20%) and fish and seafood (15%). Legumes and nuts account for 10%, while olive oil and dairy products (cheese and yogurt) each contribute 7%. Smaller portions include poultry and eggs (4%) and red meat and sweets (2%), reflecting the diet's focus on plant-based foods, healthy fats, whole grains, and moderate consumption of animal products, with minimal intake of red meat and sugary foods.",[21,9,16],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Heba Yasser Bihery, Assistant lecturer","CONTACT","01065015529","hyasser@horus.edu.eg",[46],{"facility":47,"status":30,"city":48,"state":30,"zip":30,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"out-patient clinic, faculty of physical therapy, Horus university","Cairo","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.24967,30.06263,{"lat":55,"lon":54},[58],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Heba Yasser","Principal Investigator","100053683","high-intensity-interval-training-versus-moderate-intensity-continuous-training-on-gut-microbiota-in-non-alcoholic-fatty-liver-100053683",false,"NCT07697313","High-intensity Interval Training Versus Moderate Intensity Continuous Training on Gut Microbiota in Non-alcoholic Fatty Liver","Inclusion Criteria:\n\n1. Patients from both genders aged 40 - 60 years old diagnosed with Non-alcoholic Fatty Liver disease by ultrasonography.\n2. Body mass index will range from 30 to 34.9 kg\u002Fm².\n3. Patients with central obesity (waist circumference 90 cm for men and 85 cm for women).\n4. Patients who have taken no regular exercise in the last year (\\\u003C3 times\u002Fweek and 30 min\u002Ftime.\n5. No antibiotic or probiotic use for at least last 3 months.\n6. Medical drugs such as metformin, sulfonylureas, statins, and blood pressure medication were eligible, as well as stable.\n\nExclusion Criteria:\n\n1. History of liver cirrhosis or other chronic liver diseases.\n2. Use of medications affecting gut microbiota (e.g., laxatives, metformin, proton pump inhibitors).\n3. Recent gastrointestinal infections or surgeries.\n4. Diabetes Mellitus type 1 or uncontrolled type 2.\n5. Cardiovascular, respiratory, or musculoskeletal disorders limiting exercise capacity.\n6. Active smokers.\n7. Pregnancy or breastfeeding.\n8. Uncontrolled hypertension.\n9. Communication disorders.\n10. Bleeding disorders.","ALL","40 Years","60 Years",{"count":73,"type":74},60,"ESTIMATED","INTERVENTIONAL",[77],"NA","To compare High-Intensity Interval Training versus moderate intensity continuous training on gut microbiota in Non- Alcoholic Fatty Liver.",[80],"Non-alcoholic Fatty Liver","NOT_YET_RECRUITING","2026-07-05",{"date":84,"type":85},"2026-07-13","ACTUAL",{"date":87,"type":74},"2026-07-10",{"date":89,"type":74},"2026-10-10",{"name":5,"class":6},1]