[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616193":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":46,"responsibleParty":61,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":25,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":25,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":49,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Istituti Clinici Scientifici Maugeri SpA","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-Intensity Resistance Training (HIRT)","EXPERIMENTAL","This is the group performing high-intensity strength training on the leg press, combined with low-intensity cycling; it is the intervention study group.",[13],"Other: HIRT",{"label":15,"type":16,"description":17,"interventionNames":18},"High-Intensity Endurance Training (HIET)","ACTIVE_COMPARATOR","This is the group performing high-intensity endurance training on the cycle ergometer, combined with low-intensity leg press; it is the active comparator study group (Active Comparator).",[19],"Other: HIET",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"HIRT","The HIRT group will perform high-intensity strength training on a horizontal leg press, consisting of 4 sets of 5 repetitions at 90-95% of their maximum strength (1RM). Two-minute rests are given between sets, and the weight is increased by 2.5 kg whenever a patient can do more than 5 repetitions. Training focuses on quadriceps strength, from 90° to full extension. Sessions are scheduled 2 days on, 1 day off. This method has been shown to be safe, with mild muscle soreness as the most likely side effect. In addition, participants will perform low-intensity cycling at 20% of their maximum workload, which remains constant throughout the study, to maintain light endurance activity.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"HIET","The HIET group will perform high-intensity endurance training on a cycle ergometer for 25 minutes at 70% of their maximum workload, with intensity progression of 10 watts if breathlessness is rated below 5 on the Borg scale. Each session includes a 3-minute warm-up and cool-down, with monitoring of heart rate, blood pressure, oxygen saturation, and symptoms. Participants train 5 days per week. Additionally, they perform low-intensity strength training on the horizontal leg press, 4 sets of 5 repetitions at 20% 1RM, 6-7 days per week, without progression. This combined program maintains both aerobic fitness and light muscle strength during conventional rehabilitation.",[15],[31],{"name":32,"affiliation":33,"role":34},"Mara Paneroni, PhD, MSc","ICS Maugeri IRCCS, respiratory rehabilitation of the Institute of Lumezzane","STUDY_DIRECTOR",[36,41],{"name":32,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","+0039+030+8253","167","mara.paneroni@icsmaugeri.it",{"name":42,"role":37,"phone":43,"phoneExt":44,"email":45},"Tiziana Bachetti, Pharm","+0039+0382+593","210","tiziana.bachetti@icsmaugeri.it",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":25},"ICS Maugeri IRCCS, Respiratory rehabilitation of the Institute of Lumezzane","RECRUITING","Lumezzane","Brescia","25065","Italy","IT",{"type":56,"coordinates":57},"Point",[58,59],10.26487,45.64789,{"lat":59,"lon":58},{"type":62,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[64],{"name":65,"class":6},"Universita di Verona","100616193","high-intensity-resistance-training-in-post-exacerbation-copd-100616193",false,"NCT07302425","High-intensity Resistance Training in Post-exacerbation COPD","The Effect of the High-intensity Resistance Training in COPD Patients Recovering From Hospital Exacerbation: a Pilot Study","Inclusion Criteria:\n\n* COPD diagnosis according to the GOLD guidelines \\[11\\] with FEV1\u002FFVC \\\u003C70%\n* Stable clinical condition (pH\\>7.30) \\[11\\]\n* Hospital discharge within 3 weeks from an event of hospitalization due to an acute exacerbation of COPD.\n* Absence of significant motor disability, described by the possibility of performing the 6MWT.\n\nExclusion Criteria:\n\n* Presence of lung diseases other than COPD\n* Orthopedic and neurological conditions that prevent the execution of functional tests\n* Severe neurological and cardiologic comorbidities or other severe diseases compromise exercise tolerance.\n* Cognitive impairment evaluated by Mini-Mental State Examination (MMSE) score as \\\u003C 25.","ALL","18 Years",{"count":76,"type":77},64,"ESTIMATED","INTERVENTIONAL",[80],"NA","After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity.\n\nThis study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme.\n\nThe investigators aim to determine whether MST is easier to tolerate, especially in terms of breathlessness, and whether MST can improve muscle strength, efficiency, and overall exercise tolerance as well as or better than endurance training.\n\nThe results will help identify the most suitable rehabilitation strategy for individuals recovering from a COPD exacerbation, particularly for those who struggle with high-intensity endurance exercise.",[83],"COPD Exacerbation",[85,86,87,88],"COPD","Exacerbation","Early Rehabilitation","High-intensity exercise","2025-12-10",{"date":91,"type":92},"2025-12-24","ACTUAL",{"date":94,"type":92},"2025-10-30",{"date":96,"type":77},"2028-05",{"name":5,"class":6},1]