[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636512":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":48,"collaborators":25,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":25,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":25,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":74,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS)","EXPERIMENTAL","Participants receive high-intensity transcranial alternating current stimulation (Hi-tACS) at 77.5 Hz, 15 mA for 40 minutes per session, one session per day, 5 days per week, for 4 weeks (total 20 sessions). Electrodes are placed on the forehead (Fpz, Fp1, Fp2 regions) and bilateral mastoid regions.",[13],"Device: Active High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS)","SHAM_COMPARATOR","Participants receive sham stimulation with the same electrode placement. Active stimulation is delivered only for the first 30 seconds, then ramped down to 0 mA over 10 seconds, with intermittent imperceptible skin-sensation signals for the remaining 40-minute session to mimic real stimulation. Same session schedule (20 sessions over 4 weeks).",[19],"Device: Sham High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS)",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Active Hi-tACS delivered using a transcranial alternating current stimulation device. Parameters: 77.5 Hz sinusoidal alternating current, 15 mA (peak-to-peak), 40 minutes per session. Electrode montage: one 8 cm × 4 cm electrode placed horizontally on the forehead (covering Fpz, Fp1, Fp2 regions) and two 6 cm × 2.9 cm electrodes placed on bilateral mastoid regions. Conductive gel ensures impedance \\\u003C10 kΩ. One session\u002Fday, 5 days\u002Fweek for 4 weeks (total 20 sessions).",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Sham stimulation using the same device and electrode placement as the active arm. Active stimulation is applied only for the first 30 seconds, then ramped down to 0 mA over 10 seconds. For the remaining session duration, intermittent low-intensity signals producing imperceptible skin sensation are delivered to maintain blinding. Same schedule: 40 minutes\u002Fsession, one session\u002Fday, 5 days\u002Fweek for 4 weeks (total 20 sessions).",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Hongxing Wang, MD & PhD","CONTACT","+86 13911127385","wanghongxing@xwh.ccmu.edu.cn",[36],{"facility":37,"status":25,"city":38,"state":39,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":25},"Xuanwu Hospital, Capital Medical University","Beijing","Beijing Municipality","China","CN",{"type":43,"coordinates":44},"Point",[45,46],116.39723,39.9075,{"lat":46,"lon":45},{"type":49,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100636512","high-intensity-transcranial-alternating-current-stimulation-hi-tacs-for-hypertension-a-randomized-controlled-trial-100636512",false,"NCT07566650","High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS) for Hypertension: A Randomized Controlled Trial","A Randomized Controlled Trial of High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS) for the Treatment of Essential Hypertension","Inclusion Criteria:\n\n* Clinical diagnosis of primary hypertension (Grade 1-3) as defined by the Chinese Hypertension Guidelines (Revised Edition 2024).\n* For females of childbearing potential, agreement to use contraception during the study.\n* Willing and able to comply with study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Women who are pregnant, breastfeeding, or planning pregnancy during the study period.\n* Resistant hypertension (blood pressure uncontrolled despite adherence to ≥3 antihypertensive drugs of different classes at optimal doses, including a diuretic ), or known secondary hypertension.\n* History of severe cardiovascular or cerebrovascular disease (e.g., myocardial infarction, stroke, heart failure NYHA Class III-IV) within the past 6 months, or severe hepatic or renal dysfunction (defined as ALT\u002FAST \\>3× upper limit of normal \\[ULN\\], or eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²).\n* Uncontrolled sleep apnea syndrome, active infectious diseases, chronic wasting diseases, or significant cognitive impairment.\n* Current major psychiatric disorder as assessed by the Mini-International Neuropsychiatric Interview (M.I.N.I.).\n* Contraindications to tACS or MRI: implanted electronic devices, intracranial metal implants, or known history of seizures.\n* Skin lesions, eczema, or broken skin at the intended electrode placement sites.\n* Participation in another clinical trial involving an investigational product or device within 30 days prior to screening.\n* Any condition that, in the opinion of the investigator, would jeopardize the patient's safety or compliance with the study protocol, or interfere with data interpretation.","ALL","18 Years","65 Years",{"count":61,"type":62},50,"ESTIMATED","INTERVENTIONAL",[65],"NA","This study focuses on individuals with primary hypertension, with the main objective of investigating the effectiveness and safety of high-intensity transcranial alternating current stimulation (Hi-tACS) as a non-invasive, non-pharmacological treatment for hypertension",[68],"Primary Hypertension",[70,71,72,73],"transcranial alternating current stimulation","autonomic nervous system","neuromodulation","primary hypertension","NOT_YET_RECRUITING","2026-04-29",{"date":77,"type":78},"2026-05-05","ACTUAL",{"date":80,"type":62},"2026-05-01",{"date":82,"type":62},"2028-05-01",{"name":5,"class":6},1]