[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582489":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":156,"collaborators":29,"id":158,"slug":159,"hasResults":160,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":160,"sex":166,"minAge":167,"maxAge":29,"enrollmentInfo":168,"targetDuration":29,"studyType":171,"phases":172,"briefSummary":174,"conditions":175,"keywords":29,"overallStatus":42,"whyStopped":29,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":187},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"ADEM non-MOGAD","EXPERIMENTAL","Non-MOGAD ADEM control group of 5 patients with anti-MOG antibody-negative ADEM",[13],"Other: Blood test",{"label":15,"type":16,"description":17,"interventionNames":18},"ADEM MOGAD","ACTIVE_COMPARATOR","Single-phase and multi-phase ADEM MOGAD units respectively",[13],{"label":20,"type":10,"description":21,"interventionNames":22},"MOGAD non-ADEM","MOGAD non-ADEM central nervous system demyelinating neuroinflammatory control group (anti-MOG antibody-positive optic neuritis or myelitis) of 5 patients",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"OTHER","Blood test","Drawing blood to realize biomarkers of disease course of MOGAD-ADEM and pathophysiology of ADEM (and MOGAD) : cellular and molecular signatures, inflammatory signaling.",[15,9,20],null,[31],{"name":32,"affiliation":5,"role":33},"Nail BENALLEGUE, DOCTOR","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":29,"email":38},"CONTACT","+33241354445","nail.benallegue@chu-angers.fr",[40,57,71,85,100,114,128,142],{"facility":41,"status":42,"city":43,"state":29,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"CHU d'Angers","RECRUITING","Angers","49240","France","FR",{"type":48,"coordinates":49},"Point",[50,51],-0.55202,47.47156,{"lat":51,"lon":50},[54],{"name":55,"role":36,"phone":56,"phoneExt":29,"email":38},"Nail Benallegue, Doctor","+332 41 35 44 45",{"facility":58,"status":42,"city":59,"state":29,"zip":60,"country":45,"countryCode":46,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Univesity Hostipal of Brest","Brest","29200",{"type":48,"coordinates":62},[63,64],-4.48628,48.39029,{"lat":64,"lon":63},[67],{"name":68,"role":36,"phone":69,"phoneExt":29,"email":70},"Juliette Ropars, MD","33-(0)2-98-22-33-89","juliette.ropars@chu-brest.fr",{"facility":72,"status":42,"city":73,"state":29,"zip":74,"country":45,"countryCode":46,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Univesity Hostipal of APHP","Le Kremlin-Bicêtre","94270",{"type":48,"coordinates":76},[77,78],2.36073,48.81471,{"lat":78,"lon":77},[81],{"name":82,"role":36,"phone":83,"phoneExt":29,"email":84},"Deiva Kumaran, MD","33-(0)1-45-21-31-12","kumaran.deiva@aphp.fr",{"facility":86,"status":87,"city":88,"state":29,"zip":89,"country":45,"countryCode":46,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"CHU Montpellier","NOT_YET_RECRUITING","Montpellier","34295",{"type":48,"coordinates":91},[92,93],3.87635,43.61093,{"lat":93,"lon":92},[96],{"name":97,"role":36,"phone":98,"phoneExt":29,"email":99},"Pierre MEYER, DR","+334 67 33 74 22","p-meyer@chu-montpellier.fr",{"facility":101,"status":42,"city":102,"state":29,"zip":103,"country":45,"countryCode":46,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Univesity Hostipal of Nantes","Nantes","44093",{"type":48,"coordinates":105},[106,107],-1.55336,47.21725,{"lat":107,"lon":106},[110],{"name":111,"role":36,"phone":112,"phoneExt":29,"email":113},"Capucine GLASSON, MD","33-(0)2-40-16-51-76","capucine.lefebvre@chu-nantes.fr",{"facility":115,"status":87,"city":116,"state":29,"zip":117,"country":45,"countryCode":46,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Hôpital Necker Enfants Malades","Paris","75015",{"type":48,"coordinates":119},[120,121],2.3488,48.85341,{"lat":121,"lon":120},[124],{"name":125,"role":36,"phone":126,"phoneExt":29,"email":127},"Mélodie AUBART, DR","+331 42 19 26 93","melodie.aubart@aphp.fr",{"facility":129,"status":42,"city":130,"state":29,"zip":131,"country":45,"countryCode":46,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Univesity Hostipal of Rennes","Rennes","35000",{"type":48,"coordinates":133},[134,135],-1.67431,48.11109,{"lat":135,"lon":134},[138],{"name":139,"role":36,"phone":140,"phoneExt":29,"email":141},"Silvia Napuri-Peirano, MD","33-(0)2-99-26-71-14","Silviaadriana.napuri.peirano@chu-rennes.fr",{"facility":143,"status":42,"city":144,"state":29,"zip":145,"country":45,"countryCode":46,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Univesity Hostipal of Tours","Tours","37000",{"type":48,"coordinates":147},[148,149],0.70398,47.39484,{"lat":149,"lon":148},[152],{"name":153,"role":36,"phone":154,"phoneExt":29,"email":155},"Pierre Castelnau, MD","33-(0)2-47-47-47-47","castelnau@univ-tours.fr",{"type":157,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100582489","high-throughput-omic-technology-for-identification-of-biomarkers-of-relapsing-acute-disseminated-encephalomyelitis-in-immune-cell-network-100582489",false,"NCT06863974","High-throughput Omic Technology for Identification of Biomarkers of Relapsing Acute Disseminated Encephalomyelitis in Immune Cell Network","High-throughput Omic Technology for Identification of Biomarkers of Relapsing Acute Disseminated Encephalomyelitis in the Immune Cell Network","HOT-BRAIN","Inclusion criteria:\n\nProspective recruitment Pre-inclusion criteria\n\n* Age at inclusion between 1 and 18 years (included)\n* First demyelinating event at inclusion, such as ADEM encephalitis, optic neuritis (NORB) or myelitis, or a combination of these conditions.\n* Informed consent signed by patient's legal representative\n* Patient affiliated to or benefiting from a social security scheme Inclusion criteria (confirmation of inclusion and follow-up in one of 3 groups)\n* MOGAD\u002FADEM group: presence of serum anti-MOG antibodies and diagnosis of ADEM (according to the International Pediatric Multiple Sclerosis Society Group (IPMSSG) criteria revised in 2013) at the first demyelinating attack.\n* Non-MOGAD\u002FADEM group: anti-MOG antibodies negative and diagnosis of ADEM at first demyelinating attack.\n* MOGAD\u002Fnon-ADEM group: presence of serum anti-MOG antibodies and diagnosis of myelitis and\u002For NORB at first demyelinating attack.\n\nRetrospective recruitment General inclusion criteria\n\n* Age at inclusion between 1 and 18 years (inclusive)\n* Inclusion (signed consent of the patient's legal representative) in the biocollection from which the samples were taken at the latest at the time of management of a first demyelinating event of the ADEM encephalitis, optic neuritis (NORB) or myelitis type, or a combination of these disorders.\n* PBMC collected at the time of the first demyelinating event before any immunomodulatory treatment, cryopreserved and available in the biocollection.\n* Depending on the date of inclusion (if inclusion beyond 6 to 24 months after the first demyelinating event), samples taken at 6 months and then 24 months after the first demyelinating event available in the biocollection for the analyses planned in the study.\n* Informed consent signed by patient's legal representative\n* Patient affiliated to or benefiting from a social security scheme\n\nInclusion criteria specific to the 3 study groups\n\n* MOGAD\u002FADEM group: presence of serum anti-MOG antibodies and diagnosis of ADEM (according to the International Pediatric Multiple Sclerosis Society Group (IPMSSG) criteria revised in 2013) at the first demyelinating attack.\n* Non-MOGAD\u002FADEM group: anti-MOG antibodies negative and diagnosis of ADEM at first demyelinating attack.\n* MOGAD\u002Fnon-ADEM group: presence of serum anti-MOG antibodies and diagnosis of myelitis and\u002For NORB at first demyelinating attack.\n\nNon-inclusion criteria (prospective or retrospective recruitment):\n\n* Immunosuppressive therapy in the 6 months prior to treatment for a first demyelinating event.\n* Systemic corticosteroid therapy or immunomodulating doses of IV polyvalent immunoglobulin or plasma exchange within 3 months prior to treatment for a first demyelinating event.\n* Brain MRI not performed at diagnosis of first demyelinating event\n* Poor understanding of the French language","ALL","18 Years",{"count":169,"type":170},20,"ESTIMATED","INTERVENTIONAL",[173],"NA","Acute disseminated encephalomyelitis (ADEM) is a neuroinflammatory disorder of the central nervous system, manifesting itself as impaired consciousness, even to the point of coma, and multifocal neurological deficits. ADEM is the most common encephalitis in children. Moreover, 50-65% of ADEM in children is associated with the presence of anti-MOG antibodies (MOGAD). In fact, ADEM is the most frequent clinical presentation of MOGAD in children, 50-75% before the age of 10. The risk of recurrence is higher in pediatric MOGAD of ADEM manifestation, up to 30%, compared to myelitis or optic neuritis. Multiphasic MOGAD are more frequently associated with sequelae in 50-69% of cases, versus 4-32% for monophasic forms. In ADEM, cognitive and epileptic sequelae predominate. The 2020 European consortium and the 2022 national diagnosis and care protocol recommend the introduction of disease-modifying therapies as early as the second attack of the disease, or in the event of distant sequelae, in order to limit relapses and sequelae. However, these treatments take several months to take effect.\n\nThere is currently no reliable predictive factor for MOGAD recurrence other than the persistence of an elevated blood anti-MOG antibody level (≥1:1280) at 1 year. The aim of this study is therefore to identify biomarkers associated with MOGAD recurrence from the first attack. To this end, we will study the transcriptome of circulating blood mononuclear cells by single-cell next-generation RNA sequencing in children with anti-MOGAD neuroinflammatory relapses. Anticipating the multiphasic trajectory of the disease would enable the introduction of early disease-modifying therapy to prevent recurrences and long-term sequelae. Furthermore, the discovery of a molecular and\u002For cellular signature would provide a better understanding of the pathophysiology of ADEM and MOGAD.",[176,177],"Acute Disseminated Encephalomyelitis","Encephalitis Autoimmune","2026-04-21",{"date":180,"type":181},"2026-04-27","ACTUAL",{"date":183,"type":181},"2025-11-16",{"date":185,"type":170},"2030-02-01",{"name":5,"class":6},8]