[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640978":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":20,"locations":21,"responsibleParty":45,"collaborators":20,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":20,"enrollmentInfo":59,"targetDuration":20,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":24,"whyStopped":20,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Erasmus Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Simultaneous integrated boost","EXPERIMENTAL","Treatment arm, in which all participating patients will receive the simultaneous integrated boost (SIB)",[13],"Radiation: Simultaneous integrated boost to the tumor and positive mesorectal lymph nodes",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"RADIATION","Simultaneous integrated boost to the tumor and positive mesorectal lymph nodes","Addition of a simultaneous integrated boost (SIB) to the standard chemoradiotherapy (CRT) scheme of 2.0 Gy to the mesorectum. The radiotherapy scheme consists of 25 fractions, delivering 2.0 Gy per fraction to the mesorectum and 2.4 Gy per fraction to the tumor and positive mesorectal lymph nodes.",[9],null,[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Erasmus MC","RECRUITING","Rotterdam","South Holland","3015 GD","Netherlands","NL",{"type":31,"coordinates":32},"Point",[33,34],4.47917,51.9225,{"lat":34,"lon":33},[37,42],{"name":38,"role":39,"phone":40,"phoneExt":20,"email":41},"Judith Sluijter, MSc","CONTACT","+31107035792","j.sluijter@erasmusmc.nl",{"name":43,"role":44,"phone":20,"phoneExt":20,"email":20},"Claudia Schuurhuizen, PhD, MD","PRINCIPAL_INVESTIGATOR",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","Claudia Schuurhuizen","Principal Investigator","100640978","higher-radiation-dose-to-the-tumor-may-help-avoid-surgery-in-rectal-cancer-patients-100640978",false,"NCT07616297","Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients","REctal Organ Preservation With a BOost Approach Using CBCT-based Online Adaptive radioTherapy","REBOOT","Inclusion Criteria:\n\n* Age ≥18 years\n* Eastern cooperative oncology group (ECOG) performance status ≤2\n* Histologically confirmed rectal adenocarcinoma\n* Non-locally advanced rectal cancer, defined as (magnetic resonance imaging (MRI)-based) T1-3, N0\u002FN1 (≤3 positive mesorectal lymph nodes), MX\u002FM0\n* Indication for curative treatment with organ preservation\n* Discussed in the multidisciplinary tumor board (MTB)\n* Written informed consent\n\nExclusion Criteria:\n\n* Previous radiotherapy in the pelvic area\n* Other malignancies, except for adequately treated basal cell carcinoma (BCC), at time of inclusion or within 3 years prior to inclusion\n* Contra-indications for (chemo)radiotherapy or surgery\n* Presence of lateral lymph nodes, cN2 status, extramural vascular invasion (EMVI) or mesorectal fascia involvement as seen on MRI\n* Mucinous defined tumor on MRI\n* Prior local excision of the primary tumor\n* DPD (dihydropyrimidine dehydrogenase) deficiency\n* Unable to understand the requirements of the study and to give written informed consent, as determined by the treating physician","ALL","18 Years",{"count":60,"type":61},25,"ESTIMATED","INTERVENTIONAL",[64],"NA","The goal of this prospective study is to evaluate if a higher radiation dose to the tumor can increase the organ preservation rate in non-locally advanced rectal cancer.",[67,68],"Rectal Cancer","Radiation Oncology",[68,70,71],"Rectal cancer","Organ Preservation","2026-05-29",{"date":74,"type":75},"2026-06-01","ACTUAL",{"date":77,"type":75},"2026-01-27",{"date":79,"type":61},"2030-08-01",{"name":47,"class":6},1]