[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586538":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":36,"centralContacts":49,"locations":59,"responsibleParty":76,"collaborators":36,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":36,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":36,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":36,"overallStatus":62,"whyStopped":36,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Al Hayah University In Cairo","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-Dose HILT (10 J\u002Fcm²)","EXPERIMENTAL","Participants receive High-Intensity Laser Therapy at a dosage of 10 J\u002Fcm² per treatment zone, 3 times per week for 4 weeks (12 sessions total).",[13],"Device: Low-Dose High-Intensity Laser Therapy (10 J\u002Fcm²)",{"label":15,"type":10,"description":16,"interventionNames":17},"Medium-Dose HILT (15 J\u002Fcm²)","Participants receive High-Intensity Laser Therapy at a dosage of 15 J\u002Fcm² per treatment zone, 3 times per week for 4 weeks (12 sessions total).",[18],"Device: Medium-Dose High-Intensity Laser Therapy (15 J\u002Fcm²)",{"label":20,"type":10,"description":21,"interventionNames":22},"High-Dose HILT (20 J\u002Fcm²)","Participants receive High-Intensity Laser Therapy at a dosage of 20 J\u002Fcm² per treatment zone, 3 times per week for 4 weeks (12 sessions total).",[23],"Device: High-Dose High-Intensity Laser Therapy (20 J\u002Fcm²)",{"label":25,"type":26,"description":27,"interventionNames":28},"Sham HILT","SHAM_COMPARATOR","Participants receive a sham High-Intensity Laser Therapy procedure using the same device and application technique, but with no energy delivered, 3 times per week for 4 weeks (12 sessions total).",[29],"Device: Sham High-Intensity Laser Therapy",[31,37,41,45],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DEVICE","Low-Dose High-Intensity Laser Therapy (10 J\u002Fcm²)","Application of HILT using an Nd:YAG laser (BTL-6000, 1064 nm). Delivered via continuous scanning technique (1 cm distance) to 5 zones (25 cm² each) covering anterior, medial, and lateral knee aspects. Target dose: 10 J\u002Fcm² per zone. Session frequency: 3x\u002Fweek for 4 weeks (12 total). Session duration: 15-20 min. Administered by trained PTs in outpatient rehab. Skin temperature monitored.",[9],null,{"type":32,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Medium-Dose High-Intensity Laser Therapy (15 J\u002Fcm²)","Application of HILT using an Nd:YAG laser (BTL-6000, 1064 nm). Delivered via continuous scanning technique (1 cm distance) to 5 zones (25 cm² each) covering anterior, medial, and lateral knee aspects. Target dose: 15 J\u002Fcm² per zone. Session frequency: 3x\u002Fweek for 4 weeks (12 total). Session duration: 15-20 min. Administered by trained PTs in outpatient rehab. Skin temperature monitored.",[15],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"High-Dose High-Intensity Laser Therapy (20 J\u002Fcm²)","Application of HILT using an Nd:YAG laser (BTL-6000, 1064 nm). Delivered via continuous scanning technique (1 cm distance) to 5 zones (25 cm² each) covering anterior, medial, and lateral knee aspects. Target dose: 20 J\u002Fcm² per zone. Session frequency: 3x\u002Fweek for 4 weeks (12 total). Session duration: 15-20 min. Administered by trained PTs in outpatient rehab. Skin temperature monitored.",[20],{"type":32,"name":46,"description":47,"armGroupLabels":48,"otherNames":36},"Sham High-Intensity Laser Therapy","Sham procedure mimicking active HILT using the same Nd:YAG laser device (BTL-6000). Same setup, patient positioning, scanning technique over identical zones, and session duration\u002Ffrequency (3x\u002Fweek, 4 weeks, 15-20 min). Device powered on with visual\u002Fauditory cues active, but no laser energy emitted. Administered by trained PTs in outpatient rehab. Skin temperature monitored.",[25],[50,55],{"name":51,"role":52,"phone":53,"phoneExt":36,"email":54},"Ibrahim Zoheiry, Ph.D","CONTACT","01277774949","ibrahim.alzoheiry@hotmail.com",{"name":56,"role":52,"phone":57,"phoneExt":36,"email":58},"Mohamed ElMeligie, Ph.D","01159880001","mohamed.elmeligie@ahuc.edu.eg",[60],{"facility":61,"status":62,"city":63,"state":36,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Faculty of Physical Therapy, Al Hayah University","RECRUITING","Cairo","12311","Egypt","EG",{"type":68,"coordinates":69},"Point",[70,71],31.24967,30.06263,{"lat":71,"lon":70},[74],{"name":56,"role":52,"phone":57,"phoneExt":75,"email":58},"+20",{"type":77,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100586538","hilt-dose-optimization-for-knee-osteoarthritis-pain-100586538",false,"NCT06916676","HILT Dose Optimization for Knee Osteoarthritis Pain","Optimal High-Intensity Laser Therapy (HILT) Parameters for Pain and Function in Patients With Moderate Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\nAge between 45 and 75 years, inclusive. Clinical diagnosis of knee osteoarthritis according to American College of Rheumatology (ACR) criteria (knee pain plus at least 3 of 6: age \\>50, morning stiffness \\\u003C30 min, crepitus, bony tenderness, bony enlargement, no palpable warmth).\n\nRadiographic evidence of knee osteoarthritis corresponding to Kellgren-Lawrence grade II or III in the target knee.\n\nAverage knee pain intensity ≥ 4 on a 10-cm Visual Analogue Scale (VAS) during weight-bearing activities in the past week.\n\nWillingness and ability to attend 3 sessions per week for 4 weeks and attend all assessment sessions.\n\nExclusion Criteria:\n\nPrevious surgery on the index knee (including arthroscopy within the last year or joint replacement).\n\nDiagnosis of inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis, gout).\n\nIntra-articular corticosteroid or hyaluronic acid injection in the index knee within the last 3 months.\n\nClinically significant comorbidities that could interfere with participation or assessment (e.g., severe uncontrolled cardiovascular disease, severe pulmonary disease, significant neurological deficits affecting the lower limb).\n\nPresence of skin conditions (e.g., infection, open wounds, eczema, photosensitivity disorders) in the area designated for laser treatment.\n\nCurrent use of anticoagulant medication (e.g., warfarin, DOACs) due to potential risk, unless stable and cleared by physician. (Consider if this is truly necessary based on HILT mechanism).\n\nHistory of cancer in the treatment area or active malignancy elsewhere. Known photosensitivity or use of photosensitizing medications. Pregnancy, planning pregnancy, or breastfeeding. Participation in another interventional clinical trial within the last 30 days. Inability to understand or communicate in the study language.","ALL","18 Years","65 Years",{"count":89,"type":90},140,"ESTIMATED","INTERVENTIONAL",[93],"NA","This study aims to find the best settings (dose) for High-Intensity Laser Therapy (HILT) to reduce pain and improve function in people with moderate knee osteoarthritis. Participants will be randomly assigned to receive one of three different doses of HILT (low, medium, or high) or a sham (placebo) laser treatment, three times a week for four weeks. The main outcomes measured will be changes in knee pain (using a pain scale) and knee function (using a questionnaire) from the beginning to the end of the 4-week treatment period.",[96],"Knee Osteoarthritis","2025-04-01",{"date":99,"type":100},"2025-04-08","ACTUAL",{"date":102,"type":90},"2025-04-23",{"date":104,"type":90},"2027-06-01",{"name":5,"class":6},1]