[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616764":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":114,"collaborators":10,"id":117,"slug":118,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":119,"sex":125,"minAge":10,"maxAge":10,"enrollmentInfo":126,"targetDuration":10,"studyType":129,"phases":10,"briefSummary":130,"conditions":131,"keywords":141,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"St. Antonius Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Early surgery",null,"Surgery within 24 hours after last DOAC intake",{"label":13,"type":10,"description":14,"interventionNames":10},"Delayed surgery","Surgery after more than 24 hours after last DOAC intake",[16],{"name":17,"affiliation":18,"role":19},"Henk Jan Schuijt, MD, PhD","Amsterdam University Medical Center","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Tim Schiepers, MD","CONTACT","+31637557472","t.schiepers@antoniusziekenhuis.nl",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"+31651915397","h.j.schuijt@amsterdamumc.nl",[30,46,58,70,82,94,106],{"facility":31,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Ziekenhuisgroep Twente Hospital","RECRUITING","Almelo","Netherlands","NL",{"type":37,"coordinates":38},"Point",[39,40],6.6625,52.35667,{"lat":40,"lon":39},[43],{"name":44,"role":23,"phone":24,"phoneExt":10,"email":45},"Han Hegeman, MD, PhD","h.hegeman@zgt.nl",{"facility":47,"status":32,"city":48,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"Onze Lieve Vrouw Gasthuis Hospital","Amsterdam",{"type":37,"coordinates":50},[51,52],4.88969,52.37403,{"lat":52,"lon":51},[55],{"name":56,"role":23,"phone":24,"phoneExt":10,"email":57},"Diederik Kempen, MD, PhD","D.H.R.Kempen@olvg.nl",{"facility":59,"status":32,"city":60,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Rijnstate Hospital","Arnhem",{"type":37,"coordinates":62},[63,64],5.91111,51.98,{"lat":64,"lon":63},[67],{"name":68,"role":23,"phone":24,"phoneExt":10,"email":69},"Diederik Smeeing, MD, PhD","dsmeeing@rijnstate.nl",{"facility":71,"status":32,"city":72,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Deventer Hospital","Deventer",{"type":37,"coordinates":74},[75,76],6.16389,52.255,{"lat":76,"lon":75},[79],{"name":80,"role":23,"phone":24,"phoneExt":10,"email":81},"Elvira Flikweert, MD, PhD","elviraflikweert@hotmail.com",{"facility":83,"status":32,"city":84,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Martini Hospital","Groningen",{"type":37,"coordinates":86},[87,88],6.56667,53.21917,{"lat":88,"lon":87},[91],{"name":92,"role":23,"phone":24,"phoneExt":10,"email":93},"Eelke Bosma, MD, PhD","eelke.bosma@mzh.nl",{"facility":95,"status":32,"city":96,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Diakonessenhuis Hospital","Utrecht",{"type":37,"coordinates":98},[99,100],5.12222,52.09083,{"lat":100,"lon":99},[103],{"name":104,"role":23,"phone":24,"phoneExt":10,"email":105},"Frans Jasper Wijdicks, MD, PhD","fwijdicks@diakhuis.nl",{"facility":5,"status":32,"city":96,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":107,"geoPoint":109,"contacts":110},{"type":37,"coordinates":108},[99,100],{"lat":100,"lon":99},[111,112],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"name":113,"role":23,"phone":27,"phoneExt":10,"email":28},"Henk Schuijt, MD, PhD",{"type":19,"investigatorFullName":115,"investigatorTitle":116,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Tim Schiepers","Medical Doctor","100616764","hip-fracture-surgery-timing-and-blood-transfusion-risk-in-patients-on-doacs-100616764",false,"NCT07309848","Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs","Blood Transfusion Risk After Early vs. Delayed Surgery in Hip Fracture Patients on Direct Oral Anticoagulants: A Natural Experiment","OPTIMIZEDOAC","Inclusion Criteria:\n\n* Isolated hip fracture classified as AO\u002FOTA 31A or 31B requiring surgical intervention.\n* Current DOAC use with the last dose taken ≤24 hours before emergency department (ED) presentation\n\nExclusion Criteria:\n\n* Pathologic or periprosthetic hip fractures.\n* Fracture sustained \\>24 hours before ED presentation.\n* Inter-hospital transfer.\n* Hematologic disorders (e.g., thalassemia, sickle cell disease, aplastic anemia, myelodysplastic syndromes, leukemia).\n* Use of a non-EMA-approved DOAC (e.g., betrixaban).","ALL",{"count":127,"type":128},374,"ESTIMATED","OBSERVATIONAL","This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting longer can also increase risks such as complications and longer hospital stays. The purpose of this study is to find out whether operating within 24 hours is as safe as delaying surgery beyond 24 hours. Specifically, the investigators want to know if early surgery does not lead to a higher need for blood transfusions compared to delayed surgery.",[132,133,134,135,136,137,138,139,140],"Blood Transfusion","Hip Fracture Surgeries","Geriatric","Bleeding Complications","Bleeding as Surgical Complication (Treatment)","Bleeding","Blood Transfusions","Blood Transfusion Complication","Direct Oral Anticoagulants (DOACs)",[142,143,144,145,146,147,148,149,150,151],"natural experiment","doac","direct oral anticoagulant","hip fracture","geriatric","surgery","bleeding","blood transfusion","early","delayed","2025-12-15",{"date":154,"type":155},"2025-12-30","ACTUAL",{"date":157,"type":155},"2025-11-01",{"date":159,"type":128},"2027-12-31",{"name":5,"class":6},7]