[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641313":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":35,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Assiut University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Group 1: Control Group",null,"Group 1: Control Group\n\nWomen with normal ovarian reserve undergoing In Vitro Fertilization (IVF) due to non-ovarian causes of infertility such as male factor infertility or tubal factor infertility.",{"label":13,"type":10,"description":14,"interventionNames":10},"Group 2: DOR Group","Group 2: DOR Group\n\nWomen diagnosed with diminished ovarian reserve according to at least two of the following criteria:\n\nAnti-Müllerian Hormone (AMH) ≤1.1 ng\u002FmL\n\nAntral Follicle Count (AFC) ≤7\n\nBasal Follicle-Stimulating Hormone (FSH) ≥10 IU\u002FL",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Abeer Othman Fahmi Mohammed","CONTACT","01099067741","abeerothman.1995@aun.edu.eg",[22],{"facility":23,"status":10,"city":24,"state":10,"zip":10,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Faculty of Medicine, Assiut University","Asyut","Egypt","EG",{"type":28,"coordinates":29},"Point",[30,31],31.18368,27.18096,{"lat":31,"lon":30},[34],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":36,"investigatorFullName":17,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Assistant Lecturer of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University","100641313","hippo-related-competing-endogenous-rna-cerna-network-dysregulation-and-in-vitro-fertilization-ivf-outcomes-in-women-with-diminished-ovarian-reserve-100641313",false,"NCT07658846","Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve","Investigating the Dysregulation of the Hippo-Related ceRNA Network and Its Impact on IVF Outcomes in Patients With Diminished Ovarian Reserve (DOR)","DOR-HIPPO-IVF","Inclusion Criteria:\n\n* Women undergoing In Vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI) cycles.\n* Infertility duration of at least one year\n* Primary or secondary infertility.\n\nExclusion Criteria:\n\n* Polycystic Ovary Syndrome (PCOS)\n* Endometriosis.\n* Ovarian tumors or malignancy.\n* Severe systemic diseases affecting fertility.\n* Metabolic syndrome.\n* Connective tissue disorders.\n* Hormonal therapy within the last three months.\n* Refusal to participate.","FEMALE","18 Years","40 Years",{"count":50,"type":51},70,"ESTIMATED","OBSERVATIONAL","Diminished Ovarian Reserve (DOR) is an important cause of female infertility and is associated with poor ovarian response and lower pregnancy rates during In Vitro Fertilization (IVF). The molecular mechanisms underlying impaired follicular development in DOR remain incompletely understood. Increasing evidence suggests that non-coding RNAs and components of the Hippo signaling pathway play important roles in granulosa cell proliferation, apoptosis, and follicular development.\n\nThis prospective observational cohort study aims to investigate the expression of the long non-coding RNA (lncRNA) Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), microRNA (miRNA)-181a-5p, Hippo pathway components including Yes-Associated Protein 1 (YAP1) and Connective Tissue Growth Factor (CTGF), and Insulin-Like Growth Factor 1 (IGF1) in follicular fluid-derived cells from women with DOR undergoing IVF compared with women with normal ovarian reserve. The study will also evaluate relationships among these molecular markers and IVF outcomes, including oocyte quality, number of retrieved oocytes, and embryo developmental potential.",[55,56,57],"Diminished Ovarian Reserve","Female Infertility","In Vitro Fertilization",[59,60,61,62,63,64,65,66,67],"Diminished Ovarian Reserve (DOR)","In Vitro Fertilization (IVF)","Hippo Signaling Pathway","Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)","microRNA-181a-5p","Yes-Associated Protein 1 (YAP1)","Connective Tissue Growth Factor (CTGF)","Insulin-Like Growth Factor 1 (IGF1)","Follicular Fluid","NOT_YET_RECRUITING","2026-06-17",{"date":71,"type":72},"2026-06-22","ACTUAL",{"date":74,"type":51},"2026-08-01",{"date":76,"type":51},"2028-10-01",{"name":5,"class":6},1]