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(NHLBI)","100459661","his-bundle-corrective-pacing-in-heart-failure-100459661",false,"NCT05265520","His-Bundle Corrective Pacing in Heart Failure","HIS-CRT","Inclusion Criteria:\n\n* Age 18 years or older (no upper age limit)\n* Optimal medical therapy for heart failure by current guidelines\n* Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:\n\n  * New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb)\n\nExclusion Criteria:\n\n* Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization\n* Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology\n* Unable or unwilling to follow study protocol\n* Less than 12 months life expectancy at consent\n* Pregnancy or planned pregnancy during duration of the study\n* On heart transplant list or likely to undergo heart transplant","ALL","18 Years",{"count":262,"type":263},120,"ESTIMATED","INTERVENTIONAL",[266],"NA","The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).",[269,270,271,272],"Right Bundle-Branch Block","Heart Failure","His-bundle Pacing","Cardiac Resynchronization Therapy","2026-02-04",{"date":275,"type":276},"2026-02-09","ACTUAL",{"date":278,"type":276},"2022-12-02",{"date":280,"type":263},"2028-07-01",{"name":5,"class":6},14]